TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T05407 XX ID T05407 XX DT 06.02.2003 (created); sth. DT 09.06.2015 (updated); mkl. CO Copyright (C), QIAGEN. XX FA ehf XX SY EHF; ESE3; ESEJ. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G005048 EHF; HGNC: EHF. XX CL C0016; ETS; XX SF two splice variants ehfa T05412 and ehfb T05413; SF ehfa lacks amino acid 159-181 [2]; XX CP expressed exclusively in differentiated epithelial cells [1]; highest expression in glandular epithelium from prostate, pancreas, salivary gland, trachea [2] [1] [2]. XX FF context-dependent transcriptional repressor downstream of MAPK signaling cascades [1]; FF repressor of the Ras- or phorbol ester-induced transcriptional activation of a subset of promoters that contain ETS and AP-1 binding sites [1]; XX IN T05448 ESE-1; human, Homo sapiens. XX MX M02052 V$EHF_03. MX M03965 V$EHF_08. MX M07251 V$EHF_Q6. XX DR TRANSPATH: MO000054287. DR UniProtKB: Q9NZC4; Q9Y5V4. XX RN [1]; RE0022434. RX PUBMED: 11259407. RA tugores A., Le J., Sorokina I., Snijders A. J., Duyao M., Reddy P. S., Carlee L., Ronshaugen M., Mushegian A., Watanaskul T., Chu S., Buckler A., Emtage S., McCormick M. K. RT The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades. RL J. Biol. Chem. 276:20397-20406 (2001). RN [2]; RE0022459. RX PUBMED: 10644770. RA Kas K., Finger E., Grall F., Gu X., Akbarali Y., Boltax J., Weiss A., Oettgen P., Kapeller R., Libermann T. A. RT ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. RL J. Biol. Chem. 275:2986-2998 (2000). RN [3]; RE0054487. RX PUBMED: 17027647. RA Lim J. H., Cho J. Y., Park Y. B., Park J. W., Kwon T. K. RT ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites. RL Biochem. Biophys. Res. Commun. 350:736-741 (2006). XX //