AC T05409
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ID T05409
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DT 10.02.2003 (created); vma.
DT 22.01.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA AML2
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SY Acute myeloid leukemia 2 protein; AML2; CBF-alpha 3; Core-binding factor, alpha 3 subunit; PEBP2A3; Polyomavirus enhancer binding protein 2 alpha C subunit; Runt-related transcription factor 3; RUNX3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005055 Runx3.
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CL C0029; runt; 6.4.1.0.3.
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SF one of two isoforms of PEBP2alphaC produced by alternative splicing;
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CP CD8 SP thymocytes [1].
CN CD4 SP and immature thymocytes [1].
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FF Knockdown of Runx3 inhibits the down-regulation of CD4 expression, thereby inhibiting the development of CD4-/CD8+ T cells [1];
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MX M01759 V$AML2_01.
MX M01814 V$AML2_Q3.
MX M01854 V$AML2_Q3_01.
MX M07372 V$AML2_Q4.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00984 V$PEBP_Q6.
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BS R65840.
BS R65842.
BS R65846.
BS R65847.
BS R65849.
BS R61482.
BS R20208.
BS R38957.
BS R29498.
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DR TRANSPATH: MO000034576.
DR UniProtKB: Q64131;
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RN [1]; RE0048862.
RX PUBMED: 14500656.
RA Ehlers M., Laule-Kilian K., Petter M., Aldrian C. J., Grueter B., Wurch A., Yoshida N., Watanabe T., Satake M., Steimle V.
RT Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytes.
RL J. Immunol. 171:3594-3604 (2003).
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