AC T05952
XX
ID T05952
XX
DT 05.05.2004 (created); abd.
DT 30.05.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA HFH-1
XX
SY forkhead box Q1; Foxq1; HNF-3/forkhead homolog 1; HNF-3/forkhead homolog 1 like; satin.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009966 Foxq1.
XX
CL C0023; fork head.
XX
SF binds to the AT-rich region of telokin promoter [1];
SF the forkhead DNA-binding domain is responsible for the inhibitory activity of HFH-1 [1];
XX
CP ribonuclease protection assay: (highest level in) bladder and stomach, (weaker signals in) ileum, proximal and distal colons, vas deferens, liver, lung, kidney and brain [1]; in situ hybridization: stomach epithelial cells of the mucosa and in the interstitial tissue between circular and longitudinal muscle layers [1] [1].
CN jejunum, uterus, skeletal muscle, heart and aorta [1].
XX
FF controls hair follicle differentiation [2];
FF repressor [1];
XX
DR TRANSPATH: MO000041888.
DR UniProtKB: O70220;
XX
RN [1]; RE0024170.
RX PUBMED: 10896677.
RA Hoggatt A. M., Kriegel A. M., Smith A. F., Herring B. P.
RT Hepatocyte nuclear factor-3 homologue 1 (HFH-1) represses transcription of smooth muscle-specific genes.
RL J. Biol. Chem. 275:31162-31170 (2000).
RN [2]; RE0048559.
RX PUBMED: 16835220.
RA Potter C. S., Peterson R. L., Barth J. L., Pruett N. D., Jacobs D. F., Kern M. J., Argraves W. S., Sundberg J. P., Awgulewitsch A.
RT Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation.
RL J. Biol. Chem. 281:29245-29255 (2006).
RN [3]; RE0048563.
RX PUBMED: 11309849.
RA Hong H. K., Noveroske J. K., Headon D. J., Liu T., Sy M. S., Justice M. J., Chakravarti A.
RT The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice.
RL Genesis 29:163-171 (2001).
XX
//