AC T06073
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ID T06073
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DT 04.08.2004 (created); oke.
DT 04.12.2006 (updated); kau.
CO Copyright (C), QIAGEN.
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FA Net-b
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SY ELK3; ELK3, member of ETS oncogene family; ERP; Etrp; SAP-2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009412 Elk3.
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CL C0016; ETS.
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SZ 249 AA; 28.7 kDa (cDNA) (calc.).
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SQ MESAITLWQFLLHLLLDQKHEHLICWTSNDGEFKLLKAEEVAKLWGLRKNKTNMNYDKLS
SQ RALRYYYDKNIIKKVIGQKFVYKFVSFPDILKMDPHAVEISRESLLLQDGDCKVSPEGRE
SQ VHRHGLSSLKSASRNEYLHSGLYSSFTINSLENAPEAFKAIKTEKLEEPCDDSPPVEEVR
SQ TVIRQKTQRLGNLCTPTVALRHRHRLHRPQQPSPPLRIPHSSLLHRTDTKWTVSGLESAA
SQ AQHTLLEQP
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SC modified from EMBL #Z32815 according to [1]
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FT 1 69 
A-box, ETS domain [1].
FT 1 183 
N-terminal, common for Net and Net-b [1].
FT 4 87 
PF00178; Ets-domain.
FT 4 89 
SM00413; etsneu2.
FT 5 85 
PS50061; ETS_DOMAIN_3.
FT 7 75 
PS50140; HSF_ETS.
FT 151 183 
HLH motif, Net inhibitory domain [1].
FT 184 249 
C-terminal, unique for Net-b [1].
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SF one of the several splice variants encoded by Elk3 gene G009412;
SF for Net-c mRNA is known, but protein is not found [1];
SF B domain interacts with SRF;
SF lack the C domain (phosphorylation site) [1];
SF unique C-terminal part results from the shift of reading frame [1];
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CP heard, thymus, spleen, lung, liver [1].
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FF repressor [1];
FF forms ternary complexes with SRF on the c-fos SRE [1];
FF in contrast to Net, is not activated by Ras [1];
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IN T05114 SRF; mouse, Mus musculus.
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MX M00971 V$ETS_Q6.
MX M03832 V$NET_Q6.
MX M08824 V$NET_Q6_01.
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DR TRANSPATH: MO000043189.
DR EMBL: Z32815; MMNETRN.
DR UniProtKB: P41971; NET_MOUSE.
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RN [1]; RE0024210.
RX PUBMED: 9315625.
RA Giovane A., Sobieszczuk P., Ayadi A., Maira S. M., Wasylyk B.
RT Net-b, a Ras-insensitive factor that forms ternary complexes with serum response factor on the serum response element of the fos promoter.
RL Mol. Cell. Biol. 17:5667-5678 (1997).
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