AC T06112
XX
ID T06112
XX
DT 23.08.2004 (created); oke.
DT 05.08.2009 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA E2F-7
XX
SY A630014C11Rik; D10Ertd739e; E2F transcription factor 7; E2f7.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009882 E2f7.
XX
HO E2F-like proteins of Arabidopsis.
XX
CL C0023; fork head; 3.3.2.1.7.
XX
SF possesses two distinct DNA-binding domains that are similar to each other and to DBDs of other E2F family members [1];
SF has tree nuclear localization motifs [1];
SF lacks a dimerization, transcriptional activation, Rb-binding and cyclin A-binding domains [1];
SF structure is more similar to the plant E2Fs than to other mammalian E2Fs [1];
XX
CP highest level in the skin and thymus, low levels in heart, lung, small intestine, spleen, testis [1].
CN brain, muscle, stomach [1].
XX
FF repressor of a subset of E2F target genes [1];
FF binds E2F consensus sites [1];
FF inhibits cellular proliferation [1];
FF expression is cell cycle regulated, probably through E2F binding elements in its promoter [1];
FF tissue-specific and cell cycle-dependent expression with a peak at S phase [1];
XX
MX M08875 V$E2F_Q4_03.
MX M00920 V$E2F_Q6_01.
XX
DR TRANSPATH: MO000043499.
DR UniProtKB: Q6S7F2; Q6S7F2.
XX
RN [1]; RE0024650.
RX PUBMED: 12893818.
RA de Bruin A., Maiti B., Jakoi L., Timmers C., Buerki R., Leone G.
RT Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation.
RL J. Biol. Chem. 278:42041-42049 (2003).
RN [2]; RE0063217.
RX PUBMED: 18194653.
RA Li J., Ran C., Li E., Gordon F., Comstock G., Siddiqui H., Cleghorn W., Chen H. Z., Kornacker K., Liu C. G., Pandit S. K., Khanizadeh M., Weinstein M., Leone G., de Bruin A.
RT Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
RL Dev. Cell 14:62-75 (2008).
XX
//