DT 03.01.2005 (created); elf.
DT 16.11.2007 (updated); bch.
CO Copyright (C), QIAGEN.
SY Gli homologous protein 1; Gli5; Gli6; GliH1; GLIS family zinc finger 1; GLIS1.
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
GE G013721 Glis1.
HO Gli family of proteins.
CL C0001; CH; 188.8.131.52.4.
SF protein with five C2H2 zinc finger domains homologous to the Gli proteins ;
SF nuclear protein ;
CP limb buds at 10,0 dpc, branchial arches, craniofacial interface, ventral part of the tail, whisker follicles, hair, invertebral discs, teeth, eyes (lens, presumptive iris, ciliary body, eyelids) and kidney (S-shaped tubules, proximal or distal renal tubules) ; 10,5 dpc additional expression in developing maxillary process, mandibular arch and hyoid arch ; 11,0 dpc overall expression became stronger in craniofacial interface mesoderm ; Northern Blot and RT-PCR: most highly in kidney and placenta/ medium in testis/ low in brain, heart, stomach, small intestine, colon, brown fat tissue, skin, thymus, uterus / in situ hybridization on mouse embryos: expression in a temporal and spatial manner during development: highly in craniofacial regions, branchial arches, somites, vibrissae, hair follicles, limb buds, myotomes   .
CN developing neural tube at the stages 7,5 to 12,5 dpc , retina, urethral bud epithelium, glomerulus at 15,5 dpc ; nervous system ; lung, liver, spleen, skeletal muscle, pancreas   .
FF The zinc finger domain of GliH1 can bind to Gli DNA binding sequences, and in a co-transfection assay in odontoblasts GliH1 can inhibit the activation activity of Gli1 T06385 ;
FF GliH1 is not regulated by Shh unlike Gli1 T06385 ;
FF transcriptional repressor ;
FF Glis1 contains a strong activation domain at its carboxyl-terminal region and the activity of this activation function was suppressed by a repressor domain at its amino-terminal half, whereas the degree of transcriptional activation by Glis1 is dependent on cell-type ;
FF stimulation of Glis1 -dependent transcriptional activation by Ca2+ -dependent calmodulin kinases ;
IN T06118 RORgamma-isoform1; mouse, Mus musculus.
MX M06844 V$GLIH1_01.
MX M01037 V$GLI_Q2.
MX M07292 V$GLI_Q3.
DR TRANSPATH: MO000045209.
DR UniProtKB: Q8K1M4; GZI1_MOUSE.
RN ; RE0025256.
RX PUBMED: 12385751.
RA Nakashima M., Tanese N., Ito M., Auerbach W., Bai C., Furukawa T., Toyono T., Akamine A., Joyner A. L.
RT A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.
RL Mech. Dev. 119:21-34 (2002).
RN ; RE0025419.
RX PUBMED: 12042312.
RA Kim Y. S., Lewandoski M., Perantoni A. O., Kurebayashi S., Nakanishi G., Jetten A. M.
RT Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions.
RL J. Biol. Chem. 277:30901-30913 (2002).