TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T06390 XX ID T06390 XX DT 03.01.2005 (created); elf. DT 16.11.2007 (updated); bch. CO Copyright (C), QIAGEN. XX FA GliH1 XX SY Gli homologous protein 1; Gli5; Gli6; GliH1; GLIS family zinc finger 1; GLIS1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G013721 Glis1. XX HO Gli family of proteins. XX CL C0001; CH; XX SF protein with five C2H2 zinc finger domains homologous to the Gli proteins [1]; SF nuclear protein [2]; XX CP limb buds at 10,0 dpc, branchial arches, craniofacial interface, ventral part of the tail, whisker follicles, hair, invertebral discs, teeth, eyes (lens, presumptive iris, ciliary body, eyelids) and kidney (S-shaped tubules, proximal or distal renal tubules) [1]; 10,5 dpc additional expression in developing maxillary process, mandibular arch and hyoid arch [1]; 11,0 dpc overall expression became stronger in craniofacial interface mesoderm [1]; Northern Blot and RT-PCR: most highly in kidney and placenta/ medium in testis/ low in brain, heart, stomach, small intestine, colon, brown fat tissue, skin, thymus, uterus / in situ hybridization on mouse embryos: expression in a temporal and spatial manner during development: highly in craniofacial regions, branchial arches, somites, vibrissae, hair follicles, limb buds, myotomes [2] [1] [2]. CN developing neural tube at the stages 7,5 to 12,5 dpc [1], retina, urethral bud epithelium, glomerulus at 15,5 dpc [1]; nervous system [1]; lung, liver, spleen, skeletal muscle, pancreas [2] [1] [2]. XX FF The zinc finger domain of GliH1 can bind to Gli DNA binding sequences, and in a co-transfection assay in odontoblasts GliH1 can inhibit the activation activity of Gli1 T06385 [1]; FF GliH1 is not regulated by Shh unlike Gli1 T06385 [1]; FF transcriptional repressor [1]; FF Glis1 contains a strong activation domain at its carboxyl-terminal region and the activity of this activation function was suppressed by a repressor domain at its amino-terminal half, whereas the degree of transcriptional activation by Glis1 is dependent on cell-type [2]; FF stimulation of Glis1 -dependent transcriptional activation by Ca2+ -dependent calmodulin kinases [2]; XX IN T06118 RORgamma-isoform1; mouse, Mus musculus. XX MX M06844 V$GLIH1_01. MX M01037 V$GLI_Q2. MX M07292 V$GLI_Q3. XX DR TRANSPATH: MO000045209. DR UniProtKB: Q8K1M4; GZI1_MOUSE. XX RN [1]; RE0025256. RX PUBMED: 12385751. RA Nakashima M., Tanese N., Ito M., Auerbach W., Bai C., Furukawa T., Toyono T., Akamine A., Joyner A. L. RT A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development. RL Mech. Dev. 119:21-34 (2002). RN [2]; RE0025419. RX PUBMED: 12042312. RA Kim Y. S., Lewandoski M., Perantoni A. O., Kurebayashi S., Nakanishi G., Jetten A. M. RT Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. RL J. Biol. Chem. 277:30901-30913 (2002). XX //