AC T06583
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ID T06583
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DT 06.05.2005 (created); ili.
DT 08.05.2013 (updated); vad.
CO Copyright (C), QIAGEN.
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FA securin
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SY EAP1; ESP1-associated protein 1; HPTTG; pituitary tumor-transforming 1; pituitary tumor-transforming protein 1; PTTG; PTTG1; securin; tumor transforming protein 1; TUTR1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013651 PTTG1; HGNC: PTTG1.
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FF securin is involved in the regulation of sister-chromatid separation [1];
FF appear to be important in maintaining cell survival [2];
FF repressed by p53 [2];
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IN T00671 p53; human, Homo sapiens.
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DR TRANSPATH: MO000044992.
DR UniProtKB: O95997; PTTG1_HUMAN.
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RN [1]; RE0025241.
RX PUBMED: 12355087.
RA Bernal J. A., Luna R., Espina A., Lazaro I., Ramos-Morales F., Romero F., Arias C., Silva A., Tortolero M., Pintor-Toro J. A.
RT Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.
RL Nat. Genet. 32:306-311 (2002).
RN [2]; RE0035154.
RX PUBMED: 15016801.
RA Kho P. S., Wang Z., Zhuang L., Li Y., Chew J. L., Ng H. H., Liu E. T., Yu Q.
RT p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis.
RL J. Biol. Chem. 279:21183-21192 (2004).
RN [3]; RE0039232.
RX PUBMED: 11179223.
RA Zur A., Brandeis M.
RT Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis
RL EMBO J. 20:792-801 (2001).
RN [4]; RE0048865.
RX PUBMED: 16868023.
RA Holland A. J., Taylor S. S.
RT Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction.
RL J. Cell Sci. 119:3325-3336 (2006).
RN [5]; RE0049806.
RX PUBMED: 16479161.
RA Jeganathan K. B., Baker D. J., van Deursen J. M.
RT Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition.
RL Cell Cycle 5:366-370 (2006).
RN [6]; RE0050997.
RX PUBMED: 17604273.
RA Holland A. J., Bottger F., Stemmann O., Taylor S. S.
RT Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.
RL J. Biol. Chem. 282:24623-24632 (2007).
RN [7]; RE0051647.
RX PUBMED: 15166217.
RA Choudhury A. D., Xu H., Baer R.
RT Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression.
RL J. Biol. Chem. 279:33909-33918 (2004).
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