TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T06593 XX ID T06593 XX DT 19.05.2005 (created); elf. DT 21.04.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA Gfi1 XX SY GFI1; Growth factor independence-1; growth factor independent 1; pal-1; Pal1; Zinc finger protein Gfi-1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G018222 Gfi1. XX CL C0001; CH; XX CP bone marrow, thymus, lymphopoietic thymus, lesser extent in spleen and testis [4]. EX bone marrow,,,adult; very high; Northern blot; total RNA; [4]. EX thymus,,,adult; very high; Northern blot; total RNA; [4]. XX FF repressor [1]; FF position- and orientation-independent active transcriptional repressor [3]; FF Gfi1 releases cells from a G1 block induced by IL-2 withdrawal and is targeted by proviral integration in a number of tumor systems [3]; FF role in stem cell differentiation [2]; FF absence of Gfi1 disrupts the functional integrity of bone marrow hematopoietic stem cells, Gfi1 deficiency leads to an exhaustion of hematopoietic stem cells in the adult mouse bone marrow [5]; XX MX M00250 V$GFI1_01. MX M01067 V$GFI1_Q6. MX M02010 V$GFI1_Q6_01. XX BS R16779. BS R16786. BS R16787. BS R16957. BS R16962. BS R16964. BS R16965. BS R16966. BS R31972. BS R67264. BS R67286. XX DR TRANSPATH: MO000054417. DR UniProtKB: P70338; GFI1_MOUSE. XX RN [1]; RE0035163. RX PUBMED: 15131254. RA Doan L. L., Porter S. D., Duan Z., Flubacher M. M., Montoya D., Tsichlis P. N., Horwitz M., Gilks C. B., Grimes H. L. RT Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells. RL Nucleic Acids Res. 32:2508-2519 (2004). RN [2]; RE0035164. RX PUBMED: 12721361. RA Duan Z., Horwitz M. RT Targets of the transcriptional repressor oncoprotein Gfi-1. RL Proc. Natl. Acad. Sci. USA 100:5932-5937 (2003). RN [3]; RE0035172. RX PUBMED: 8887656. RA Grimes H. L., Chan T. O., Zweidler-McKay P. A., Tong B., Tsichlis P. N. RT The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. RL Mol. Cell. Biol. 16:6263-6272 (1996). RN [4]; RE0035205. RX PUBMED: 9566867. RA Tong B., Grimes H. L., Yang T. Y., Bear S. E., Qin Z., Du K., El-Deiry W. S., Tsichlis P. N. RT The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. RL Mol. Cell. Biol. 18:2462-2473 (1998). RN [5]; RE0035270. RX PUBMED: 15668120. RA Cellot S., Sauvageau G. RT Gfi-1: another piece in the HSC puzzle. RL Trends Immunol. 26:68-71 (2005). RN [6]; RE0066056. RX PUBMED: 18652815. RA Kirjavainen A., Sulg M., Heyd F., Alitalo K., Yla-Herttuala S., Moroy T., Petrova T. V., Pirvola U. RT Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. RL Dev. Biol. 322:33-45 (2008). XX //