AC T08225
XX
ID T08225
XX
DT 08.09.2005 (created); ili.
DT 09.01.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA MafA
XX
SY hMafA; MAFA; Pancreatic beta-cell specific transcriptional activator; RIPE3b1; Transcription factor mammalian MafA; v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian).
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G021405 MAFA; HGNC: MAFA.
XX
CL C0008; bZIP; 1.1.3.1.2.
XX
SF shares S/P/T-rich acidic N-terminus with other large Maf proteins (c-Maf, MafB, NRL) [1];
SF suggested to bind (the RIPE3b element) as homodimer [1];
SF most of the posttranslational modification that alters the molecular size of the protein were concluded to affect the N-terminal 138 AA [1];
XX
FF MafA, Pdx1, and Beta2 synergistically activate the insulin gene promoter in the hamster insulinoma-derived cell line In1024 [2];
XX
MX M01139 V$LMAF_Q2.
MX M01709 V$MAFA_Q4.
MX M07325 V$MAFA_Q4_01.
MX M03796 V$MAFA_Q5.
XX
BS R65660.
BS R65673.
BS R20765.
XX
DR TRANSPATH: MO000056423.
DR UniProtKB: Q8NHW3; Q8NHW3_HUMAN.
XX
RN [1]; RE0035529.
RX PUBMED: 12011435.
RA Olbrot M., Rud J., Moss L. G., Sharma A.
RT Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.
RL Proc. Natl. Acad. Sci. USA 99:6737-6742 (2002).
RN [2]; RE0048170.
RX PUBMED: 15993959.
RA Aramata S., Han S. I., Yasuda K., Kataoka K.
RT Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1.
RL Biochim. Biophys. Acta 1730:41-46 (2005).
XX
//