AC T08243
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ID T08243
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DT 11.10.2005 (created); elf.
DT 02.02.2010 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Plzf
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SY PLZF; promyelocytic leukemia zinc finger; ZBTB16; Zfp145; Zinc finger protein 145; Zinc finger protein PLZF.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G021427 Zbtb16.
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CL C0001; CH; 2.3.3.0.74.
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CP expression in segmental patterns in the hindbrain [1]; Plzf is highly expressed in developing central nervous system, limb buds, perinatal kidney, liver, heart; expression in hematopoietic system and in primitive multipotent hematopoietic cell lines [4].
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FF effective repression of the r3/r5 enhancer of Hoxb2 reporter by PLZF requires both the PLZF-RE motif and Box1 (A/T-rich binding site) [2];
FF Plzf transcripts in myeloid HL60 and NB4 cells decline during retinoic acid-induced differentiation suggesting that Plzf plays an important role in myeloid development [4];
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MX M04625 V$PLZFB_Q3.
MX M01075 V$PLZF_02.
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BS R26634.
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DR TRANSPATH: MO000056466.
DR UniProtKB: Q3UQ17;
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RN [1]; RE0010771.
RX PUBMED: 7892256.
RA Cook M., Gould A., Brand N., Davies J., Strutt P., Shaknovich R., Licht J., Waxman S., Chen Z., Gluecksohn-Waelsch S., Krumlauf R., Zelent Z.
RT Expression of the zink-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain
RL Proc. Natl. Acad. Sci. USA 92:2249-2253 (1995).
RN [2]; RE0035545.
RX PUBMED: 12802276.
RA Ivins S., Pemberton K., Guidez F., Howell L., Krumlauf R., Zelent A.
RT Regulation of Hoxb2 by APL-associated PLZF protein.
RL Oncogene 22:3685-3697 (2003).
RN [3]; RE0044001.
RX PUBMED: 14657020.
RA Senbonmatsu T., Saito T., Landon E. J., Watanabe O., Price E. Jr, Roberts R. L., Imboden H., Fitzgerald T. G., Gaffney F. A., Inagami T.
RT A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy
RL EMBO J. 22:6471-82 (2003).
RN [4]; RE0035557.
RX PUBMED: 9278395.
RA Li J. Y., English M. A., Ball H. J., Yeyati P. L., Waxman S., Licht J. D.
RT Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein.
RL J. Biol. Chem. 272:22447-22455 (1997).
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