AC T08316
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ID T08316
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DT 19.12.2005 (created); mkl.
DT 31.12.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA Oct3
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SY DADB-104B20.2; MGC22487; Oct-3; Oct-4; OCT3; Oct4; Otf-3; OTF3; OTF4; POU class 5 homeobox 1; POU domain, class 5, transcription factor 1; POU5F1; POU5F1B.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002472 POU5F1; HGNC: POU5F1.
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CL C0007; POU; 3.1.10.5.1.
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CN NB1, NB2 [1]; normal human heart, thymus and peripheral white blood cells [1].
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FF transcriptional activator [1];
FF Oct3 (Oct4), Sox2, Nanog, and Lin28 are sufficient to reprogram somatic cells to pluripotent stem cells. [2];
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IN T19227 DRRS; human, Homo sapiens.
IN T28811 Sall4B; human, Homo sapiens.
IN T04915 Sox-2; human, Homo sapiens.
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MX M03837 V$OCT3_Q6.
MX M01125 V$OCT4_01.
MX M01124 V$OCT4_02.
MX M00795 V$OCT_Q6.
MX M01307 V$POU5F1_01.
MX M04735 V$POU5F1_04.
MX M04960 V$POU5F1_05.
MX M08780 V$POU5F1_06.
MX M08958 V$POU5F1_08.
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BS R24468.
BS R64339.
BS R64341.
BS R31504.
BS R27427.
BS R59692.
BS R59693.
BS R71183.
BS R71185.
BS R64787.
BS R66364.
BS R64905.
BS R57162.
BS R66361.
BS R19260.
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DR TRANSPATH: MO000056618.
DR TRANSCOMPEL: C00472.
DR TRANSCOMPEL: C00476.
DR UniProtKB: Q01860; PO5F1_HUMAN.
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RN [1]; RE0030609.
RX PUBMED: 12841847.
RA Wang P., Branch D. R., Bali M., Schultz G. A., Goss P. E., Jin T.
RT The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells.
RL Biochem. J. 375:199-205 (2003).
RN [2]; RE0064994.
RX PUBMED: 18029452.
RA Yu J., Vodyanik M. A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J. L., Tian S., Nie J., Jonsdottir G. A., Ruotti V., Stewart R., Slukvin I. I., Thomson J. A.
RT Induced pluripotent stem cell lines derived from human somatic cells.
RL Science 318:1917-1920 (2007).
RN [3]; RE0066003.
RX PUBMED: 19718018.
RA Kim J. B., Greber B., Arauzo-Bravo M. J., Meyer J., Park K. I., Zaehres H., Scholer H. R.
RT Direct reprogramming of human neural stem cells by OCT4.
RL Nature 461:649-643 (2009).
RN [4]; RE0071951.
RX PUBMED: 21296877.
RA Nishi M., Akutsu H., Masui S., Kondo A., Nagashima Y., Kimura H., Perrem K., Shigeri Y., Toyoda M., Okayama A., Hirano H., Umezawa A., Yamamoto N., Lee S. W., Ryo A.
RT A distinct role for Pin1 in the induction and maintenance of pluripotency.
RL J. Biol. Chem. 286:11593-11603 (2011).
RN [5]; RE0072535.
RX PUBMED: 18568018.
RA Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R., Rao B. M., Dembowy J., Yaffe M. B., Zandstra P. W., Wrana J. L.
RT TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
RL Nat. Cell Biol. 10:837-848 (2008).
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