AC T08596
XX
ID T08596
XX
DT 20.01.2006 (created); jay.
DT 12.04.2013 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA ER-alpha
XX
SY ER; ER-alpha; Era; ERalpha; ER[a]; ESR; ESR1; Estr; Estra; estradiol receptor; estrogen receptor; estrogen receptor 1 (alpha); NR3A1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006037 Esr1.
XX
CL C0002; CC (rec); 2.1.1.2.1.1.
XX
SZ 599 AA; 66.9 kDa (cDNA) (calc.).
XX
SQ MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAY
SQ EFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQ
SQ LSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIM
SQ ESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKS
SQ CQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPL
SQ VIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVH
SQ MINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGK
SQ CVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIH
SQ RVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPL
SQ YDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI
XX
SC translated from EMBL:M38651
XX
FT 1 188 
Ligand Activation Domain (AF 1) [2].
FT 1 185 
PF02159; Oestrogen receptor.
FT 25 505 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 186 257 
SM00399; c4gold.
FT 186 261 
PS51030; NUCLEAR_REC_DBD_2.
FT 187 262 
PF00105; Zinc finger, C4 type (two domains).
FT 189 249 
DNA Binding Domain [2].
FT 255 599 
LIgand Binding Domain [2].
FT 352 522 
SM00430; holi.
FT 355 547 
PF00104; Ligand-binding domain of nuclear hormon.
FT 540 552 Helix 12 [2].
XX
FF Helix 12 domain is required for enhancer repression of Neu G000349 [2];
XX
IN T09446 c-Jun; Mammalia.
IN T19335 TIF1a-short; human, Homo sapiens.
IN T04945 TIF1a; human, Homo sapiens.
XX
MX M07283 V$ERALPHA_Q4.
MX M03547 V$ERALPHA_Q6_01.
MX M03820 V$ERALPHA_Q6_02.
MX M00191 V$ER_Q6.
MX M00959 V$ER_Q6_02.
XX
BS R25135.
XX
DR TRANSPATH: MO000078321.
DR EMBL: M38651; MMESTRU.
DR UniProtKB: P19785; ESTR_MOUSE.
XX
RN [1]; RE0017308.
RX PUBMED: 9115274.
RA Thenot S., Henriquet C., Rochefort H., Cavailles V.
RT Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1
RL J. Biol. Chem. 272:12062-12068 (1997).
RN [2]; RE0027450.
RX PUBMED: 10698518.
RA Newman S. P., Bates N. P., Vernimmen D., Parker M. G., Hurst H. C.
RT Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer.
RL Oncogene 19:490-7 (2000).
RN [3]; RE0047728.
RX PUBMED: 8887632.
RA L'Horset F., Dauvois S., Heery D. M., Cavailles V., Parker M. G.
RT RIP-140 interacts with multiple nuclear receptors by means of two distinct sites.
RL Mol. Cell. Biol. 16:6029-6036 (1996).
RN [4]; RE0047810.
RX PUBMED: 14701856.
RA Debril M. B., Gelman L., Fayard E., Annicotte J. S., Rocchi S., Auwerx J.
RT Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.
RL J. Biol. Chem. 279:16677-16686 (2004).
RN [5]; RE0048348.
RX PUBMED: 9892017.
RA Alen P., Claessens F., Schoenmakers E., Swinnen J. V., Verhoeven G., Rombauts W., Peeters B.
RT Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform.
RL Mol. Endocrinol. 13:117-128 (1999).
XX
//