AC T08657
XX
ID T08657
XX
DT 30.10.2002 (created); spi.
DT 02.07.2010 (updated); ada.
CO Copyright (C), QIAGEN.
XX
FA STAT3-isoform1
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SY 1110034C02Rik; APRF; signal transducer and activator of transcription 3; STAT3; STAT3A.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G005732 Stat3.
XX
CL C0039; STAT.
XX
SZ 770 AA; 88.0 kDa (cDNA) (calc.).
XX
SQ MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
SQ LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
SQ TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQ SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
SQ ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
SQ HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
SQ QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVINMEESNNGSLSAEFKHLTLREQRCGN
SQ GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
SQ NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
SQ GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
SQ KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
SQ DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
SQ TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
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SC translated from EMBL:L29278
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FT 2 122 
PF02865; STAT_int.
FT 138 319 
PF01017; STAT_alpha.
FT 321 574 
PF02864; STAT_bind.
FT 406 514 
DNA-binding specificity determining domain [1].
FT 580 670 
PS50001; SH2.
FT 584 674 
PF00017; SH2.
XX
IN T06054 islet1-isoform1; mouse, Mus musculus.
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MX M00225 V$STAT3_01.
MX M00497 V$STAT3_02.
MX M07065 V$STAT3_Q4.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
XX
BS R17089.
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DR TRANSPATH: MO000033431.
DR EMBL: L29278;
DR EMBL: U06922;
DR UniProtKB: P42227-1;
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RN [1]; RE0003481.
RX PUBMED: 7774815.
RA Horvath C. M., Wen Z., Darnell jr J. E.
RT A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
RL Genes Dev. 9:984-994 (1995).
RN [2]; RE0026644.
RX PUBMED: 10823829.
RA Zhang Y., Turkson J., Carter-Su C., Smithgall T., Levitzki A., Kraker A., Krolewski J. J., Medveczky P., Jove R.
RT Activation of stat3 in v-src-transformed fibroblasts requires cooperation of jak1 kinase activity
RL J. Biol. Chem. 275:24935-44 (2000).
RN [3]; RE0047403.
RX PUBMED: 15659653.
RA Hao A., Novotny-Diermayr V., Bian W., Lin B., Lim C. P., Jing N., Cao X.
RT The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities.
RL Mol. Biol. Cell 16:1569-1583 (2005).
RN [4]; RE0048823.
RX PUBMED: 11940572.
RA Ren Z., Schaefer T. S.
RT ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
RL J. Biol. Chem. 277:38486-38493 (2002).
RN [5]; RE0050457.
RX PUBMED: 16636048.
RA Darnowski J. W., Goulette F. A., Guan Y. J., Chatterjee D., Yang Z. F., Cousens L. P., Chin Y. E.
RT Stat3 cleavage by caspases: impact on full-length Stat3 expression, fragment formation, and transcriptional activity.
RL J. Biol. Chem. 281:17707-17717 (2006).
RN [6]; RE0055306.
RX PUBMED: 17295906.
RA Matthews J. R., Watson S. M., Tevendale M. C., Watson C. J., Clarke A. R.
RT Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines.
RL BMC Cancer 7:29 (2007).
RN [7]; RE0066884.
RX PUBMED: 10982829.
RA Zhang T., Kee W. H., Seow K. T., Fung W., Cao X.
RT The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6.
RL Mol. Cell. Biol. 20:7132-7139 (2000).
RN [8]; RE0067254.
RX PUBMED: 12361954.
RA Novotny-Diermayr V., Zhang T., Gu L., Cao X.
RT Protein kinase C delta associates with the interleukin-6 receptor subunit glycoprotein (gp) 130 via Stat3 and enhances Stat3-gp130 interaction.
RL J. Biol. Chem. 277:49134-49142 (2002).
XX
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