AC T08885
XX
ID T08885
XX
DT 02.05.2006 (created); kar.
CO Copyright (C), QIAGEN.
XX
FA Vav-isoform1
XX
SY p95vav; Vav; Vav-1; Vav1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004620 VAV1; HGNC: VAV1.
XX
CL C0013; HLH-ZIP.
XX
SZ 845 AA; 98.3 kDa (cDNA) (calc.).
XX
SQ MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV
SQ NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI
SQ AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS
SQ EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI
SQ EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA
SQ REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL
SQ DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM
SQ DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ
SQ GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF
SQ YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF
SQ QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH
SQ GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI
SQ MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS
SQ TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED
SQ YSEYC
XX
SC Swiss-Prot#P15498
XX
FT 1 119 
PS50021; CH.
FT 3 115 
SM00033; ch_5.
FT 3 120 
PF00307; Calponin homology (CH) domain.
FT 95 386 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 194 373 
PS50010; DH_2.
FT 198 372 
PF00621; RhoGEF domain.
FT 198 372 
SM00325; RhoGEF_3.
FT 402 504 
PS50003; PH_DOMAIN.
FT 403 504 
PF00169; PH domain.
FT 403 506 
SM00233; PH_update.
FT 515 564 PS50081; ZF_DAG_PE_2.
FT 516 564 SM00109; c1_12.
FT 516 568 PF00130; Phorbol esters/diacylglycerol binding domain.
FT 595 659 SM00326; SH3_2.
FT 596 658 PF07653; Variant SH3 domain.
FT 617 660 PS50002; SH3.
FT 669 752 SM00252; SH2_5.
FT 671 746 PF00017; SH2 domain.
FT 671 766 PS50001; SH2.
FT 783 843 PS50002; SH3.
FT 786 841 PF00018; SH3 domain.
FT 786 842 SM00326; SH3_2.
XX
IN T05110 Ku70; human, Homo sapiens.
XX
DR TRANSPATH: MO000080894.
DR EMBL: AF030227;
DR EMBL: M59834; HSVAVPO1.
DR EMBL: X16316; HSVAVPO.
DR UniProtKB: P15498;
XX
RN [1]; RE0017781.
RX PUBMED: 11287617.
RA Kaminuma O., Deckert M., Elly C., Liu Y. C., Altman A.
RT Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter.
RL Mol. Cell. Biol. 21:3126-3136 (2001).
RN [2]; RE0047691.
RX PUBMED: 8524317.
RA Romero F., Dargemont C., Pozo F., Reeves W. H., Camonis J., Gisselbrecht S., Fischer S.
RT p95vav associates with the nuclear protein Ku-70.
RL Mol. Cell. Biol. 16:37-44 (1996).
RN [3]; RE0047722.
RX PUBMED: 9488731.
RA Romero F., Germani A., Puvion E., Camonis J., Varin-Blank N., Gisselbrecht S., Fischer S.
RT Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner.
RL J. Biol. Chem. 273:5923-5931 (1998).
RN [4]; RE0049465.
RX PUBMED: 16273093.
RA Jones R. B., Gordus A., Krall J. A., MacBeath G.
RT A quantitative protein interaction network for the ErbB receptors using protein microarrays.
RL Nature 439:168-174 (2006).
RN [5]; RE0066822.
RX PUBMED: 15388330.
RA Shim E. K., Moon C. S., Lee G. Y., Ha Y. J., Chae S. K., Lee J. R.
RT Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase.
RL FEBS Lett. 575:35-40 (2004).
RN [6]; RE0067521.
RX PUBMED: 17050525.
RA Miletic A. V., Sakata-Sogawa K., Hiroshima M., Hamann M. J., Gomez T. S., Ota N., Kloeppel T., Kanagawa O., Tokunaga M., Billadeau D. D., Swat W.
RT Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation.
RL J. Biol. Chem. 281:38257-38265 (2006).
XX
//