AC T05110
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ID T05110
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DT 14.05.2002 (created); cch.
DT 28.08.2015 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA Ku70
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SY 70 kDa subunit of KU antigen; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC75; CTCBF; D22S671; D22S731; G22P1; KU70; lupus KU autoantigen protein p70; ML8; p70 (Ku) lupus autoantigen; thyroid autoantigen 70kDa (Ku antigen); thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa); Xrcc6.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G008050 XRCC6; HGNC: Xrcc6.
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IN T05038 ADA3; human, Homo sapiens.
IN T08487 AR-isoform1; human, Homo sapiens.
IN T00040 AR; human, Homo sapiens.
IN T08796 ASC-2; human, Homo sapiens.
IN T18378 CBP; human, Homo sapiens.
IN T00045 COUP-TF2; human, Homo sapiens.
IN T06040 CtBP2; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T10210 Evi-1; human, Homo sapiens.
IN T05111 Ku80; human, Homo sapiens.
IN T08703 Ku80; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
IN T01616 RBPJK; human, Homo sapiens.
IN T02918 TCF-4; human, Homo sapiens.
IN T08885 Vav-isoform1; human, Homo sapiens.
IN T00880 Vav; human, Homo sapiens.
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BS R28236.
BS R28295.
BS R21579.
BS R30670.
BS R41371.
BS R28233.
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DR TRANSPATH: MO000030929.
DR UniProtKB: P12956;
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RN [1]; RE0017782.
RX PUBMED: 2466842.
RA Reeves W. H., Sthoeger Z. M.
RT Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen.
RL J. Biol. Chem. 264:5047-5052 (1989).
RN [2]; RE0032491.
RX PUBMED: 15100233.
RA O'Connor M. S., Safari A., Liu D., Qin J., Songyang Z.
RT The human Rap1 protein complex and modulation of telomere length.
RL J. Biol. Chem. 279:28585-91 (2004).
RN [3]; RE0047584.
RX PUBMED: 10823961.
RA Ko L., Cardona G. R., Chin W. W.
RT Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.
RL Proc. Natl. Acad. Sci. USA 97:6212-6217 (2000).
RN [4]; RE0047691.
RX PUBMED: 8524317.
RA Romero F., Dargemont C., Pozo F., Reeves W. H., Camonis J., Gisselbrecht S., Fischer S.
RT p95vav associates with the nuclear protein Ku-70.
RL Mol. Cell. Biol. 16:37-44 (1996).
RN [5]; RE0047722.
RX PUBMED: 9488731.
RA Romero F., Germani A., Puvion E., Camonis J., Varin-Blank N., Gisselbrecht S., Fischer S.
RT Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner.
RL J. Biol. Chem. 273:5923-5931 (1998).
RN [6]; RE0048055.
RX PUBMED: 15383276.
RA Goehler H., Lalowski M., Stelzl U., Waelter S., Stroedicke M., Worm U., Droege A., Lindenberg K. S., Knoblich M., Haenig C., Herbst M., Suopanki J., Scherzinger E., Abraham C., Bauer B., Hasenbank R., Fritzsche A., Ludewig A. H., Bussow K., Coleman S. H., Gutekunst C. A., Landwehrmeyer B. G., Lehrach H., Wanker E. E.
RT A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
RL Mol. Cell 15:853-865 (2004).
RN [7]; RE0048218.
RX PUBMED: 16226712.
RA Niture S. K., Doneanu C. E., Velu C. S., Bailey N. I., Srivenugopal K. S.
RT Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.
RL Biochem. Biophys. Res. Commun. 337:1176-1184 (2005).
RN [8]; RE0048301.
RX PUBMED: 15023334.
RA Cohen H. Y., Lavu S., Bitterman K. J., Hekking B., Imahiyerobo T. A., Miller C., Frye R., Ploegh H., Kessler B. M., Sinclair D. A.
RT Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
RL Mol. Cell 13:627-638 (2004).
RN [9]; RE0048561.
RX PUBMED: 15640154.
RA Mayeur G. L., Kung W. J., Martinez A., Izumiya C., Chen D. J., Kung H. J.
RT Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.
RL J. Biol. Chem. 280:10827-10833 (2005).
RN [10]; RE0051072.
RX PUBMED: 16159877.
RA McCracken S., Longman D., Marcon E., Moens P., Downey M., Nickerson J. A., Jessberger R., Wilde A., Caceres J. F., Emili A., Blencowe B. J.
RT Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
RL J. Biol. Chem. 280:42227-42236 (2005).
RN [11]; RE0052860.
RX PUBMED: 17283121.
RA Idogawa M., Masutani M., Shitashige M., Honda K., Tokino T., Shinomura Y., Imai K., Hirohashi S., Yamada T.
RT Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
RL Cancer Res. 67:911-918 (2007).
RN [12]; RE0063191.
RX PUBMED: 14570916.
RA Lim J. W., Kim H., Kim K. H.
RT The Ku antigen-recombination signal-binding protein Jkappa complex binds to the nuclear factor-kappaB p50 promoter and acts as a positive regulator of p50 expression in human gastric cancer cells.
RL J. Biol. Chem. 279:231-237 (2004).
RN [13]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
RN [14]; RE0064025.
RX PUBMED: 18511414.
RA Ponguta L. A., Gregory C. W., French F. S., Wilson E. M.
RT Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer.
RL J. Biol. Chem. 283:20989-21001 (2008).
RN [15]; RE0070040.
RX PUBMED: 20219974.
RA Medunjanin S., Weinert S., Schmeisser A., Mayer D., Braun-Dullaeus R. C.
RT Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha.
RL Mol. Biol. Cell 21:1620-1628 (2010).
RN [16]; RE0074469.
RX PUBMED: 22693611.
RA Litchfield L. M., Riggs K. A., Hockenberry A. M., Oliver L. D., Barnhart K. G., Cai J., Pierce WM J. r., Ivanova M. M., Bates P. J., Appana S. N., Datta S., Kulesza P., McBryan J., Young L. S., Klinge C. M.
RT Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor beta transcription in breast cancer cells.
RL PLoS ONE 7:e38278 (2012).
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