AC T05111
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ID T05111
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DT 15.05.2002 (created); cch.
DT 28.08.2015 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA Ku80
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SY 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase II, 80 kDa subunit; CTC box binding factor 85 kDa subunit; CTC85; CTCBF; DNA-repair protein XRCC5; G22P2; KU80; KU86; NF IV; nuclear factor IV; thyroid-lupus autoantigen; TLAA; XRCC5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G014446 XRCC5; HGNC: XRCC5.
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IN T00036 AP-4; human, Homo sapiens.
IN T08487 AR-isoform1; human, Homo sapiens.
IN T08796 ASC-2; human, Homo sapiens.
IN T00045 COUP-TF2; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T10210 Evi-1; human, Homo sapiens.
IN T05110 Ku70; human, Homo sapiens.
IN T10416 NFAT5c; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
IN T34680 PD2; human, Homo sapiens.
IN T01616 RBPJK; human, Homo sapiens.
IN T02918 TCF-4; human, Homo sapiens.
IN T33112 TRF2; human, Homo sapiens.
IN T15251 ZEB1; human, Homo sapiens.
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BS R28236.
BS R21579.
BS R58855.
BS R22900.
BS R30670.
BS R37101.
BS R41371.
BS R60097.
BS R28233.
BS R29066.
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DR TRANSPATH: MO000031220.
DR UniProtKB: P13010; KU86_HUMAN.
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RN [1]; RE0017783.
RX PUBMED: 2760028.
RA Yaneva M., Wen J., Ayala A., Cook R.
RT cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen.
RL J. Biol. Chem. 264:13407-13411 (1989).
RN [2]; RE0032491.
RX PUBMED: 15100233.
RA O'Connor M. S., Safari A., Liu D., Qin J., Songyang Z.
RT The human Rap1 protein complex and modulation of telomere length.
RL J. Biol. Chem. 279:28585-91 (2004).
RN [3]; RE0047445.
RX PUBMED: 12077346.
RA Mahajan K. N., Nick McElhinny S. A., Mitchell B. S., Ramsden D. A.
RT Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.
RL Mol. Cell. Biol. 22:5194-5202 (2002).
RN [4]; RE0047584.
RX PUBMED: 10823961.
RA Ko L., Cardona G. R., Chin W. W.
RT Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.
RL Proc. Natl. Acad. Sci. USA 97:6212-6217 (2000).
RN [5]; RE0048301.
RX PUBMED: 15023334.
RA Cohen H. Y., Lavu S., Bitterman K. J., Hekking B., Imahiyerobo T. A., Miller C., Frye R., Ploegh H., Kessler B. M., Sinclair D. A.
RT Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
RL Mol. Cell 13:627-638 (2004).
RN [6]; RE0048561.
RX PUBMED: 15640154.
RA Mayeur G. L., Kung W. J., Martinez A., Izumiya C., Chen D. J., Kung H. J.
RT Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.
RL J. Biol. Chem. 280:10827-10833 (2005).
RN [7]; RE0052860.
RX PUBMED: 17283121.
RA Idogawa M., Masutani M., Shitashige M., Honda K., Tokino T., Shinomura Y., Imai K., Hirohashi S., Yamada T.
RT Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
RL Cancer Res. 67:911-918 (2007).
RN [8]; RE0063191.
RX PUBMED: 14570916.
RA Lim J. W., Kim H., Kim K. H.
RT The Ku antigen-recombination signal-binding protein Jkappa complex binds to the nuclear factor-kappaB p50 promoter and acts as a positive regulator of p50 expression in human gastric cancer cells.
RL J. Biol. Chem. 279:231-237 (2004).
RN [9]; RE0064025.
RX PUBMED: 18511414.
RA Ponguta L. A., Gregory C. W., French F. S., Wilson E. M.
RT Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer.
RL J. Biol. Chem. 283:20989-21001 (2008).
RN [10]; RE0070040.
RX PUBMED: 20219974.
RA Medunjanin S., Weinert S., Schmeisser A., Mayer D., Braun-Dullaeus R. C.
RT Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha.
RL Mol. Biol. Cell 21:1620-1628 (2010).
RN [11]; RE0074469.
RX PUBMED: 22693611.
RA Litchfield L. M., Riggs K. A., Hockenberry A. M., Oliver L. D., Barnhart K. G., Cai J., Pierce WM J. r., Ivanova M. M., Bates P. J., Appana S. N., Datta S., Kulesza P., McBryan J., Young L. S., Klinge C. M.
RT Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor beta transcription in breast cancer cells.
RL PLoS ONE 7:e38278 (2012).
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