AC T00036
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ID T00036
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DT 15.10.1992 (created); ewi.
DT 29.06.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA AP-4
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SY AP4.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003918 TFAP4; HGNC: TFAP4.
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HO GT-IIBalpha, GT-IIBbeta.
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CL C0012; bHLH-ZIP; 1.2.6.4.1.
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SF leucine zipper structures are dispensable for DNA-binding, but are required for dimerization in the absence of DNA [3];
SF ZIP 2 mainly supports homodimerization, but may be substituted by ZIP 1;
SF heterodimerization with E12 only after truncation of both leucine zipper motifs [3];
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FF functional interaction with AP-1;
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IN T00036 AP-4; human, Homo sapiens.
IN T00204 E12; human, Homo sapiens.
IN T00675 E12; rat, Rattus norvegicus.
IN T01787 E12; clawed frog, Xenopus laevis.
IN T05111 Ku80; human, Homo sapiens.
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MX M00005 V$AP4_01.
MX M00175 V$AP4_Q5.
MX M00176 V$AP4_Q6.
MX M00927 V$AP4_Q6_01.
MX M01860 V$AP4_Q6_02.
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BS R02076.
BS R05143.
BS R05144.
BS R05145.
BS R05146.
BS R05147.
BS R22717.
BS R22715.
BS R34715.
BS R35889.
BS R35891.
BS R60693.
BS R60694.
BS R34333.
BS R63507.
BS R01038.
BS R73795.
BS R41148.
BS R01259.
BS R64492.
BS R37330.
BS R22516.
BS R01227.
BS R01240.
BS R02378.
BS R01416.
BS R01567.
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DR TRANSPATH: MO000024660.
DR UniProtKB: Q01664;
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RN [1]; RE0000148.
RX PUBMED: 2504497.
RA Mermod N., O'Neill E. A., Kelly T. J., Tjian R.
RT The Proline-Rich Transcriptional Activator of CTF/NF-I Is Distinct from the Replication and DNA Binding Domain
RL Cell 58:741-753 (1989).
RN [2]; RE0000398.
RX PUBMED: 2850173.
RA Comb M., Mermod N., Hyman S. E., Pearlberg J., Ross M. E., Goodman H. M.
RT Proteins bound adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription
RL EMBO J. 7:3793-3805 (1988).
RN [3]; RE0000665.
RX PUBMED: 2123466.
RA Hu Y. F., Luescher B., Admon A., Mermod N., Tjian R.
RT Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity
RL Genes Dev. 4:1741-1752 (1990).
RN [4]; RE0001814.
RX PUBMED: 2833704.
RA Mermod N., Williams T. J., Tjian R.
RT Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
RL Nature 332:557-561 (1988).
RN [5]; RE0002420.
RX PUBMED: 1731330.
RA Dang C. V., Dolde C., Gillison M. L., Kato G. J.
RT Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins
RL Proc. Natl. Acad. Sci. USA 89:599-602 (1992).
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//