AC T14055
XX
ID T14055
XX
DT 06.02.2001 (created); ulg.
DT 06.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA PARP
XX
SY ADPRT; NAD+ ADP-ribosyltransferase-1; PARP-1; poly polymerase; poly(ADP-ribose) polymerase; poly-ADP-ribose synthetase-1; proPARP.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G001407 PARP1; HGNC: PARP1.
XX
SF caution: not equal to p114 S/MAR-binding activity, but concluded to contribute to it [2];
SF copurifies with SAF-A and DNA-PK [2];
XX
CP upregulated in breast cancer [2].
XX
FF its enzymatic activity prevents DNA binding of YY1, Sp1and perhaps some other transcription factors, but not the binding of all transcription factors to their sites [75];
FF DNA binding of YY1 and Sp1 remained unaffected if they were allowed to bind to their binding sites prior to activation of PARP by NAD+ [75];
FF known to bind to nicks and ends of DNA in a sequence-independent manner [1] [2];
FF binding to ends of DNA occurs at higher concentrations than binding to base unpairing regions [1];
FF ADP-ribosylation circumvents binding to base unpairing regions in vitro and may modulate binding activity in vivo [1];
FF physical interaction with the Ku autoantigen in vivo is independent of the presence of DNA and critical for synergistic binding to S/MARs [1];
FF associates with components of the DNA replication, repair, transcription and recombination machineries [2];
FF may be involved in telomere maintenance and chromosomal stability [2];
FF downregulated during cellular senescence [2];
FF modifies DNA-PK and p53 [2];
XX
IN T08487 AR-isoform1; human, Homo sapiens.
IN T00040 AR; human, Homo sapiens.
IN T00045 COUP-TF2; human, Homo sapiens.
IN T08494 Erg; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T10210 Evi-1; human, Homo sapiens.
IN T14244 GKLF-isoform2; human, Homo sapiens.
IN T21852 HDAC1; Mammalia.
IN T02718 HIF2A; human, Homo sapiens.
IN T15683 HIF2A; Mammalia.
IN T19630 Ku autoantigen; human, Homo sapiens.
IN T05110 Ku70; human, Homo sapiens.
IN T05111 Ku80; human, Homo sapiens.
IN T01925 NF-kappaB1; human, Homo sapiens.
IN T10416 NFAT5c; human, Homo sapiens.
IN T15532 NOR1; human, Homo sapiens.
IN T21588 NOR1; Mammalia.
IN T14174 NURR1; Mammalia.
IN T34034 p21Cip1; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T08711 RelA-p65; human, Homo sapiens.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
IN T29717 SIRT1; human, Homo sapiens.
IN T06312 SNA; human, Homo sapiens.
IN T02918 TCF-4; human, Homo sapiens.
IN T00915 YY1; human, Homo sapiens.
IN T09133 YY1; Mammalia.
XX
MX M01211 V$PARP_Q3.
MX M02027 V$PARP_Q4.
XX
BS R34759.
BS R34474.
BS R25795.
BS R34604.
BS R32971.
BS R60709.
BS R64479.
BS R41368.
BS R64247.
BS R64251.
BS R64253.
BS R65346.
BS R41750.
BS R23131.
BS R29551.
XX
DR TRANSPATH: MO000020396.
DR SMARTDB: SB000062.
DR UniProtKB: P09874;
XX
RN [1]; RE0013868.
RX PUBMED: 10400681.
RA Galande S., Kohwi-Shigematsu T.
RT Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences
RL J. Biol. Chem. 274:20521-20528 (1999).
RN [2]; RE0014969.
RX PUBMED: 10813395.
RA Galande S., Kohwi-Shigematsu T.
RT Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction
RL Crit. Rev. Eukaryot. Gene Expr. 10:63-72 (2000).
RN [3]; RE0018812.
RX PUBMED: 7596430.
RA Nicholson D. W., Ali A., Thornberry N. A., Vaillancourt J. P., Ding C. K., Gallant M., Gareau Y., Griffin P. R., Labelle M., Lazebnik Y. A., Munday N. A., Raju S. M., Smulson M. E., Yamin T.-T., Yu V. L., Miller D. K.
RT Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
RL Nature 376:37-43 (1995).
RN [4]; RE0021310.
RX PUBMED: 11790791.
RA Tafani M., Karpinich N. O., Hurster K. A., Pastorino J. G., Schneider T., Russo M. A., Farber J. L.
RT Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition
RL J. Biol. Chem. 277:10073-10082 (2002).
RN [5]; RE0026467.
RX PUBMED: 10764727.
RA Mukai J., Hachiya T., Shoji-Hoshino S., Kimura M. T., Nadano D., Suvanto P., Hanaoka T., Li Y., Irie S., Greene L. A., Sato T. A.
RT NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR
RL J. Biol. Chem. 275:17566-70 (2000).
RN [6]; RE0031301.
RX PUBMED: 12194973.
RA Planey S. L., Derfoul A., Steplewski A., Robertson N. M., Litwack G.
RT Inhibition of glucocorticoid-induced apoptosis in 697 pre-B lymphocytes by the mineralocorticoid receptor N-terminal domain.
RL J. Biol. Chem. 277:42188-96 (2002).
RN [7]; RE0032491.
RX PUBMED: 15100233.
RA O'Connor M. S., Safari A., Liu D., Qin J., Songyang Z.
RT The human Rap1 protein complex and modulation of telomere length.
RL J. Biol. Chem. 279:28585-91 (2004).
RN [8]; RE0034789.
RX PUBMED: 15198987.
RA Jiang H., Ren Y., Zhao J., Feng J.
RT Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis.
RL Hum. Mol. Genet. 13:1745-54 (2004).
RN [9]; RE0038615.
RX PUBMED: 15073321.
RA Tinel A., Tschopp J.
RT The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
RL Science 304:843-6 (2004).
RN [10]; RE0042226.
RX PUBMED: 12960163.
RA Hassa P. O., Buerki C., Lombardi C., Imhof R., Hottiger M. O.
RT Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1
RL J. Biol. Chem. 278:45145-53 (2003).
RN [11]; RE0045438.
RX PUBMED: 15251463.
RA Ramana K. V., Bhatnagar A., Srivastava S. K.
RT Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells
RL FEBS Lett. 570:189-94 (2004).
RN [12]; RE0048006.
RX PUBMED: 14500729.
RA Fusaro G., Dasgupta P., Rastogi S., Joshi B., Chellappan S.
RT Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling.
RL J. Biol. Chem. 278:47853-47861 (2003).
RN [13]; RE0048080.
RX PUBMED: 12930846.
RA Frouin I., Maga G., Denegri M., Riva F., Savio M., Spadari S., Prosperi E., Scovassi A. I.
RT Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners.
RL J. Biol. Chem. 278:39265-39268 (2003).
RN [14]; RE0048336.
RX PUBMED: 15637062.
RA Denis F. M., Benecke A., Di Gioia Y., Touw I. P., Cayre Y. E., Lutz P. G.
RT PRAM-1 potentiates arsenic trioxide-induced JNK activation.
RL J. Biol. Chem. 280:9043-9048 (2005).
RN [15]; RE0048401.
RX PUBMED: 16227588.
RA Takahashi Y., Karbowski M., Yamaguchi H., Kazi A., Wu J., Sebti S. M., Youle R. J., Wang H. G.
RT Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis.
RL Mol. Cell. Biol. 25:9369-9382 (2005).
RN [16]; RE0048533.
RX PUBMED: 16531411.
RA Sayan B. S., Sayan A. E., Knight R. A., Melino G., Cohen G. M.
RT p53 is cleaved by caspases generating fragments localizing to mitochondria.
RL J. Biol. Chem. 281:13566-13573 (2006).
RN [17]; RE0048561.
RX PUBMED: 15640154.
RA Mayeur G. L., Kung W. J., Martinez A., Izumiya C., Chen D. J., Kung H. J.
RT Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.
RL J. Biol. Chem. 280:10827-10833 (2005).
RN [18]; RE0048951.
RX PUBMED: 16343435.
RA Oh Y. T., Chun K. H., Oh J. I., Park J. A., Kim Y. U., Lee S. K.
RT PKCdelta modulates p21WAF1/CIP1 ability to bind to Cdk2 during TNFalpha-induced apoptosis.
RL Biochem. Biophys. Res. Commun. 339:1138-1147 (2006).
RN [19]; RE0048960.
RX PUBMED: 16822901.
RA Lavrik I. N., Golks A., Baumann S., Krammer P. H.
RT Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis.
RL Blood 108:559-565 (2006).
RN [20]; RE0048979.
RX PUBMED: 16617056.
RA Mohan J., Gandhi A. A., Bhavya B. C., Rashmi R., Karunagaran D., Indu R., Santhoshkumar T. R.
RT Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol.
RL J. Biol. Chem. 281:17599-17611 (2006).
RN [21]; RE0048994.
RX PUBMED: 17013758.
RA Yang S., Thor A. D., Edgerton S., Yang X.
RT Caspase-3 mediated feedback activation of apical caspases in doxorubicin and TNF-alpha induced apoptosis.
RL Apoptosis 11:1987-1997 (2006).
RN [22]; RE0049046.
RX PUBMED: 16777994.
RA Tyagi A., Singh R. P., Agarwal C., Agarwal R.
RT Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
RL Carcinogenesis 27:2269-2280 (2006).
RN [23]; RE0049088.
RX PUBMED: 17159900.
RA Tinel A., Janssens S., Lippens S., Cuenin S., Logette E., Jaccard B., Quadroni M., Tschopp J.
RT Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.
RL EMBO J. 26:197-208 (2006).
RN [24]; RE0049096.
RX PUBMED: 16701639.
RA Cheung H. H., Lynn Kelly N., Liston P., Korneluk R. G.
RT Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs.
RL Exp. Cell Res. 312:2347-2357 (2006).
RN [25]; RE0049122.
RX PUBMED: 16843824.
RA Prasad V., Chandele A., Jagtap J. C., Sudheer Kumar P., Shastry P.
RT ROS-triggered caspase 2 activation and feedback amplification loop in beta-carotene-induced apoptosis.
RL Free Radic. Biol. Med. 41:431-442 (2006).
RN [26]; RE0049325.
RX PUBMED: 15378010.
RA Herrant M., Jacquel A., Marchetti S., Belhacene N., Colosetti P., Luciano F., Auberger P.
RT Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.
RL Oncogene 23:7863-7873 (2004).
RN [27]; RE0049343.
RX PUBMED: 15064710.
RA Hasenjager A., Gillissen B., Muller A., Normand G., Hemmati P. G., Schuler M., Dorken B., Daniel P. T.
RT Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x(L) in a strictly caspase-3-dependent manner in human carcinoma cells.
RL Oncogene 23:4523-4535 (2004).
RN [28]; RE0049435.
RX PUBMED: 16199031.
RA Kivinen K., Kallajoki M., Taimen P.
RT Caspase-3 is required in the apoptotic disintegration of the nuclear matrix.
RL Exp. Cell Res. 311:62-73 (2005).
RN [29]; RE0049559.
RX PUBMED: 15650752.
RA Cohen L. Y., Bourbonniere M., Sabbagh L., Bouchard A., Chew T., Jeannequin P., Lazure C., Sekaly R. P.
RT Notch1 antiapoptotic activity is abrogated by caspase cleavage in dying T lymphocytes.
RL Cell Death Differ. 12:243-254 (2005).
RN [30]; RE0049607.
RX PUBMED: 17306544.
RA O'donnell M. A., Legarda-Addison D., Skountzos P., Yeh W. C., Ting A. T.
RT Ubiquitination of RIP1 Regulates an NF-kappaB-Independent Cell-Death Switch in TNF Signaling.
RL Curr. Biol. 17:418-424 (2007).
RN [31]; RE0049613.
RX PUBMED: 17101790.
RA Escaffit F., Vaute O., Chevillard-Briet M., Segui B., Takami Y., Nakayama T., Trouche D.
RT Cleavage and cytoplasmic relocalization of histone deacetylase 3 are important for apoptosis progression.
RL Mol. Cell. Biol. 27:554-567 (2007).
RN [32]; RE0049616.
RX PUBMED: 15772077.
RA Milhas D., Cuvillier O., Therville N., Clave P., Thomsen M., Levade T., Benoist H., Segui B.
RT Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis.
RL J. Biol. Chem. 280:19836-19842 (2005).
RN [33]; RE0049681.
RX PUBMED: 15897896.
RA Benali-Furet N. L., Chami M., Houel L., De Giorgi F., Vernejoul F., Lagorce D., Buscail L., Bartenschlager R., Ichas F., Rizzuto R., Paterlini-Brechot P.
RT Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion.
RL Oncogene 24:4921-4933 (2005).
RN [34]; RE0049767.
RX PUBMED: 16352606.
RA Twiddy D., Cohen G. M., MacFarlane M., Cain K.
RT Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.
RL J. Biol. Chem. 281:3876-3888 (2006).
RN [35]; RE0049803.
RX PUBMED: 16547931.
RA Karpinich N. O., Tafani M., Schneider T., Russo M. A., Farber J. L.
RT The course of etoposide-induced apoptosis in Jurkat cells lacking p53 and Bax.
RL J. Cell. Physiol. 208:55-63 (2006).
RN [36]; RE0049809.
RX PUBMED: 17126298.
RA Lu W., Finnis S., Xiang C., Lee H. K., Markowitz Y., Okhrimenko H., Brodie C.
RT Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells.
RL Biochem. Biophys. Res. Commun. 352:431-436 (2007).
RN [37]; RE0049828.
RX PUBMED: 16204234.
RA Hassa P. O., Haenni S. S., Buerki C., Meier N. I., Lane W. S., Owen H., Gersbach M., Imhof R., Hottiger M. O.
RT Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.
RL J. Biol. Chem. 280:40450-40464 (2005).
RN [38]; RE0049840.
RX PUBMED: 16123041.
RA Clarke C. A., Bennett L. N., Clarke P. R.
RT Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.
RL J. Biol. Chem. 280:35337-35345 (2005).
RN [39]; RE0049886.
RX PUBMED: 14517333.
RA Yim H., Jin Y. H., Park B. D., Choi H. J., Lee S. K.
RT Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis.
RL Mol. Biol. Cell 14:4250-4259 (2003).
RN [40]; RE0049893.
RX PUBMED: 16801388.
RA Yim H., Hwang I. S., Choi J. S., Chun K. H., Jin Y. H., Ham Y. M., Lee K. Y., Lee S. K.
RT Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.
RL J. Cell Biol. 174:77-88 (2006).
RN [41]; RE0049927.
RX PUBMED: 16780893.
RA Wang P., Shi T., Ma D.
RT Cloning of a novel human caspase-9 splice variant containing only the CARD domain.
RL Life Sci. 79:934-940 (2006).
RN [42]; RE0050087.
RX PUBMED: 16094404.
RA Henderson C. J., Aleo E., Fontanini A., Maestro R., Paroni G., Brancolini C.
RT Caspase activation and apoptosis in response to proteasome inhibitors.
RL Cell Death Differ. 12:1240-1254 (2005).
RN [43]; RE0050136.
RX PUBMED: 16526059.
RA Mantovani I., Cappellini A., Tazzari P. L., Papa V., Cocco L., Martelli A. M.
RT Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells.
RL J. Cell. Physiol. 207:836-844 (2006).
RN [44]; RE0050232.
RX PUBMED: 16524876.
RA Kwon J. E., La M., Oh K. H., Oh Y. M., Kim G. R., Seol J. H., Baek S. H., Chiba T., Tanaka K., Bang O. S., Joe C. O., Chung C. H.
RT BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
RL J. Biol. Chem. 281:12664-12672 (2006).
RN [45]; RE0050272.
RX PUBMED: 16460673.
RA Khwaja F., Tabassum A., Allen J., Djakiew D.
RT The p75(NTR) tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells.
RL Biochem. Biophys. Res. Commun. 341:1184-1192 (2006).
RN [46]; RE0050295.
RX PUBMED: 17581882.
RA Sayan B. S., Sayan A. E., Yang A. L., Aqeilan R. I., Candi E., Cohen G. M., Knight R. A., Croce C. M., Melino G.
RT Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis.
RL Proc. Natl. Acad. Sci. USA 104:10871-10876 (2007).
RN [47]; RE0050328.
RX PUBMED: 17446484.
RA Paszty K., Antalffy G., Hegedus L., Padanyi R., Penheiter A. R., Filoteo A. G., Penniston J. T., Enyedi A.
RT Cleavage of the plasma membrane Ca+ATPase during apoptosis.
RL Ann. N. Y. Acad. Sci. 1099:440-450 (2007).
RN [48]; RE0050352.
RX PUBMED: 11751908.
RA Paszty K., Verma A. K., Padanyi R., Filoteo A. G., Penniston J. T., Enyedi A.
RT Plasma membrane Ca2+ATPase isoform 4b is cleaved and activated by caspase-3 during the early phase of apoptosis.
RL J. Biol. Chem. 277:6822-6829 (2002).
RN [49]; RE0050656.
RX PUBMED: 11359788.
RA Descamps S., Toillon R. A., Adriaenssens E., Pawlowski V., Cool S. M., Nurcombe V., Le Bourhis X., Boilly B., Peyrat J. P., Hondermarck H.
RT Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways.
RL J. Biol. Chem. 276:17864-17870 (2001).
RN [50]; RE0051219.
RX PUBMED: 16273078.
RA Wang C. X., Song J. H., Song D. K., Yong V. W., Shuaib A., Hao C.
RT Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2.
RL Cell Death Differ. 13:1203-1212 (2006).
RN [51]; RE0051634.
RX PUBMED: 17068343.
RA Sarfaraz S., Afaq F., Adhami V. M., Malik A., Mukhtar H.
RT Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest.
RL J. Biol. Chem. 281:39480-39491 (2006).
RN [52]; RE0051916.
RX PUBMED: 11839750.
RA Kahns S., Lykkebo S., Jakobsen L. D., Nielsen M. S., Jensen P. H.
RT Caspase-mediated parkin cleavage in apoptotic cell death.
RL J. Biol. Chem. 277:15303-15308 (2002).
RN [53]; RE0052860.
RX PUBMED: 17283121.
RA Idogawa M., Masutani M., Shitashige M., Honda K., Tokino T., Shinomura Y., Imai K., Hirohashi S., Yamada T.
RT Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
RL Cancer Res. 67:911-918 (2007).
RN [54]; RE0054789.
RX PUBMED: 12782632.
RA Bidere N., Lorenzo H. K., Carmona S., Laforge M., Harper F., Dumont C., Senik A.
RT Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis.
RL J. Biol. Chem. 278:31401-31411 (2003).
RN [55]; RE0055088.
RX PUBMED: 18680143.
RA Ohkura N., Nagamura Y., Tsukada T.
RT Differential transactivation by orphan nuclear receptor NOR1 and its fusion gene product EWS/NOR1: possible involvement of poly(ADP-ribose) polymerase I, PARP-1.
RL J. Cell. Biochem. 105:785-800 (2008).
RN [56]; RE0055810.
RX PUBMED: 11896617.
RA Teitz T., Wei T., Liu D., Valentine V., Valentine M., Grenet J., Lahti J. M., Kidd V. J.
RT Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.
RL Oncogene 21:1848-1858 (2002).
RN [57]; RE0055924.
RX PUBMED: 17347143.
RA Lavrik I. N., Golks A., Riess D., Bentele M., Eils R., Krammer P. H.
RT Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling.
RL J. Biol. Chem. 282:13664-13671 (2007).
RN [58]; RE0056013.
RX PUBMED: 15364960.
RA Bentele M., Lavrik I., Ulrich M., Stosser S., Heermann D. W., Kalthoff H., Krammer P. H., Eils R.
RT Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis.
RL J. Cell Biol. 166:839-851 (2004).
RN [59]; RE0062978.
RX PUBMED: 19351837.
RA Okada M., Wang Y., Jang S. W., Tang X., Neri L. M., Ye K.
RT Akt phosphorylation of merlin enhances its binding to phosphatidylinositols and inhibits the tumor-suppressive activities of merlin.
RL Cancer Res. 69:4043-4051 (2009).
RN [60]; RE0063044.
RX PUBMED: 18538670.
RA Itsuki Y., Saeki M., Nakahara H., Egusa H., Irie Y., Terao Y., Kawabata S., Yatani H., Kamisaki Y.
RT Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains.
RL FEBS Lett. 582:2365-2370 (2008).
RN [61]; RE0063289.
RX PUBMED: 16543152.
RA Heale J. T., Ball AR J. r., Schmiesing J. A., Kim J. S., Kong X., Zhou S., Hudson D. F., Earnshaw W. C., Yokomori K.
RT Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair.
RL Mol. Cell 21:837-848 (2006).
RN [62]; RE0063295.
RX PUBMED: 19427857.
RA Jin L., Xiao C. L., Lu C. H., Xia M., Xing G. W., Xiong S., Liu Q. Y., Liu H., Li Y. C., Ge F., Wang Q. D., He Q. Y., Wang Y. F.
RT Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice.
RL FEBS Lett. 583:1859-1866 (2009).
RN [63]; RE0063586.
RX PUBMED: 17823654.
RA Cheriyath V., Glaser K. B., Waring J. F., Baz R., Hussein M. A., Borden E. C.
RT G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.
RL J. Clin. Invest. 117:3107-3117 (2007).
RN [64]; RE0063827.
RX PUBMED: 19308289.
RA Xu L., Chen Y., Song Q., Xu D., Wang Y., Ma D.
RT PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis.
RL Neoplasia 11:345-354 (2009).
RN [65]; RE0064516.
RX PUBMED: 19411256.
RA Liu R., Zheng H. Q., Zhou Z., Dong J. T., Chen C.
RT KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization.
RL J. Biol. Chem. 284:16791-16798 (2009).
RN [66]; RE0065004.
RX PUBMED: 18755691.
RA Huang X., Li X., Guo B.
RT KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3.
RL J. Biol. Chem. 283:29795-29801 (2008).
RN [67]; RE0066650.
RX PUBMED: 19003995.
RA Singh B., Schneider M., Knyazev P., Ullrich A.
RT UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines.
RL Int. J. Cancer 124:531-539 (2009).
RN [68]; RE0066685.
RX PUBMED: 15243584.
RA Larribere L., Khaled M., Tartare-Deckert S., Busca R., Luciano F., Bille K., Valony G., Eychene A., Auberger P., Ortonne J. P., Ballotti R., Bertolotto C.
RT PI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes.
RL Cell Death Differ. 11:1084-1091 (2004).
RN [69]; RE0070909.
RX PUBMED: 20937773.
RA Matthess Y., Raab M., Sanhaji M., Lavrik I. N., Strebhardt K.
RT Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.
RL Mol. Cell. Biol. 30:5726-5740 (2010).
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RA Kim Y., Park H., Park D., Lee Y. S., Choe J., Hahn J. H., Lee H., Kim Y. M., Jeoung D.
RT Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs.
RL J. Biol. Chem. 285:25957-25968 (2010).
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RA Rowbotham S. P., Barki L., Neves-Costa A., Santos F., Dean W., Hawkes N., Choudhary P., Will W. R., Webster J., Oxley D., Green C. M., Varga-Weisz P., Mermoud J. E.
RT Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.
RL Mol. Cell 42:285-296 (2011).
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RA Pozuelo-Rubio M.
RT Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
RL FEBS J. 277:3321-3342 (2010).
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RA Litchfield L. M., Riggs K. A., Hockenberry A. M., Oliver L. D., Barnhart K. G., Cai J., Pierce WM J. r., Ivanova M. M., Bates P. J., Appana S. N., Datta S., Kulesza P., McBryan J., Young L. S., Klinge C. M.
RT Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor beta transcription in breast cancer cells.
RL PLoS ONE 7:e38278 (2012).
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RA Li H., Bergeron L., Cryns V., Pasternack M. S., Zhu H., Shi L., Greenberg A., Yuan J.
RT Activation of caspase-2 in apoptosis.
RL J. Biol. Chem. 272:21010-21017 (1997).
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RA Oei S. L., Griesenbeck J., Schweiger M., Ziegler M.
RT Regulation of RNA polymerase II-dependent transcription by poly(ADP-ribosyl)ation of transcription factors.
RL J. Biol. Chem. 273:31644-31647 (1998).
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