AC T14244
AS T04959.
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ID T14244
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DT 31.03.2008 (created); pro.
DT 10.02.2014 (updated); prb.
CO Copyright (C), QIAGEN.
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FA GKLF-isoform2
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SY Epithelial zinc finger protein EZF; epithelial zinc-finger protein; EZF; GKLF; gut-enriched Krueppel-like factor; KLF4; Krueppel-like factor 4; Krueppel-like factor 4 (gut).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004519 KLF4; HGNC: KLF4.
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HO mouse EZF/GKLF-isoform1.
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CL C0001; CH; 2.3.1.2.4.2.
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SZ 479 AA; 51.1 kDa (cDNA) (calc.).
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SQ MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPG
SQ RPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESV
SQ AATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPP
SQ PTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGS
SQ EYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRP
SQ AAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQV
SQ PPLHYQELMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTH
SQ TGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF
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SC Swiss-Prot#O43474-1
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SF zinc finger domain is sufficient for DNA binding and interaction with p53 T00671 [2];
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IN T02268 elongin B; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
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MX M01588 V$GKLF_02.
MX M07040 V$GKLF_Q3.
MX M07289 V$GKLF_Q3_01.
MX M01835 V$GKLF_Q4.
MX M07461 V$KLF_Q3.
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BS R15675.
BS R15671.
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DR TRANSPATH: MO000125563.
DR EMBL: AF022184;
DR EMBL: U70663;
DR UniProtKB: O43474-1; F4_HUMAN.
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RN [1]; RE0017329.
RX PUBMED: 9422764.
RA Yet S. F., McA Nulty M. M., Folta S. C., Yen H. W., Yoshizumi M., Hsieh C. M., Layne M. D., Chin M. T., Wang H., Perrella M. A., Jain M. K., Lee M. E.
RT Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains
RL J. Biol. Chem. 273:1026-1031 (1998).
RN [2]; RE0024732.
RX PUBMED: 10749849.
RA Zhang W., Geiman D. E., Shields J. M., Dang D. T., Mahatan C. S., Kaestner K. H., Biggs J. R., Kraft A. S., Yang V. W.
RT The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter.
RL J. Biol. Chem. 275:18391-18398 (2000).
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