AC T00045
XX
ID T00045
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DT 25.01.1993 (created); hse.
DT 06.01.2015 (updated); msr.
CO Copyright (C), QIAGEN.
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FA COUP-TF2
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SY apolipoprotein AI regulatory protein; Apolipoprotein Repressor Protein 1; ARP-1; COUP-beta; COUP-TF II; NR2F2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004656 NR2F2; HGNC: NR2F2.
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CL C0002; CC (rec); 2.1.3.5.2.
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SF forms homodimers, can bind as monomer or homodimer [5];
SF loss of dimerization function leads to a loss of DNA-binding unless it is C-terminally truncated to AA 171;
SF often binds to DR1 elements [14];
SF can bind to DR0, DR4 elements [11];
SF has been identified as a part of the erythroid NF-E3 complex T00559 [13] [14];
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CP widespread.
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FF can act as either activator or repressor depending on the promoter context;
FF repressor of apolipoprotein AI and CIII genes and of the human erythropoietin promoter [6] [4];
FF activator of the mouse LPL promoter, FABPI promoter, rat CYP7A promoter, salmon HNF-1 promoter [8] [12] [10] [11];
FF participates in regulation of lipid metabolism and cholesterol synthesis;
FF regulates cholesterol metabolism and bile acid synthesis [11];
FF acts as an antagonistic regulator of myogenesis via directly effecting the myoD gene family [5];
FF can activate transcription synergistically with HNF-4 [9] [10] [11];
FF can act antagonistically to HNF-4 [6] [4];
FF is an important regulator of embryonic to fetal globin gene switching [13] [14];
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IN T28731 AUF1; human, Homo sapiens.
IN T00045 COUP-TF2; human, Homo sapiens.
IN T02763 EAR2; human, Homo sapiens.
IN T28743 Hp1-gamma; human, Homo sapiens.
IN T05110 Ku70; human, Homo sapiens.
IN T05111 Ku80; human, Homo sapiens.
IN T21600 nucleolin; human, Homo sapiens.
IN T24736 nucleolin; Mammalia.
IN T14055 PARP; human, Homo sapiens.
IN T02137 PC4; human, Homo sapiens.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T13796 TLS; human, Homo sapiens.
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MX M00155 V$ARP1_01.
MX M00765 V$COUPDR1_Q6.
MX M03543 V$COUPTF2_Q6.
MX M01036 V$COUPTF_Q6.
MX M00762 V$DR1_Q3.
MX M00965 V$DR4_Q2.
MX M00967 V$HNF4_Q6.
MX M07280 V$NR1NR2_Q3.
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BS R07372.
BS R07373.
BS R07374.
BS R07375.
BS R07376.
BS R07377.
BS R07378.
BS R33846.
BS R01193.
BS R00135.
BS R01612.
BS R16068.
BS R20745.
BS R22497.
BS R13058.
BS R27532.
BS R58469.
BS R58486.
BS R20457.
BS R24217.
BS R20731.
BS R15902.
BS R15904.
BS R65573.
BS R63216.
BS R65572.
BS R13048.
BS R73758.
BS R23882.
BS R65574.
BS R34123.
BS R38971.
BS R40237.
BS R16929.
BS R33850.
BS R61349.
BS R00912.
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DR TRANSPATH: MO000024664.
DR TRANSCOMPEL: C00285.
DR UniProtKB: P24468;
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RN [1]; RE0002714.
RX PUBMED: 1899293.
RA Ladias J. A. A., Karathanasis S. K.
RT Regulation of the apolipoprotein A1 gene by ARP-1, a novel member of the steroid receptor superfamily
RL Science 251:561-565 (1991).
RN [2]; RE0002994.
RX PUBMED: 1328857.
RA Tran P., Zhang X.-K., Salbert G., Hermann T., Lehmann J. M., Pfahl M.
RT COUP orphan receptors are negative regulators of retinoic acid response pathways
RL Mol. Cell. Biol. 12:4666-4676 (1992).
RN [3]; RE0003068.
RX PUBMED: 1321332.
RA Widom R. L., Rhee M., Karathanasis S. K.
RT Repression by ARP-1 sensitizes apolipoprotein AI gene responsiveness to RXRalpha and retinoic acid
RL Mol. Cell. Biol. 12:3380-3389 (1992).
RN [4]; RE0003072.
RX PUBMED: 1312668.
RA Mietus-Snyder M., Sladek F. M., Ginsburg G. S., Kuo C. F., Ladias J. A. A., Darnell jr J. E., Karathanasis S. K.
RT Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells
RL Mol. Cell. Biol. 12:1708-1718 (1992).
RN [5]; RE0010425.
RX PUBMED: 7753622.
RA Muscat G. E. O., Rea S., Downes M.
RT Identification of a regulatory function for an orphan receptor in muscle: COUP-TF II affects the expression of the myoD gene family during myogenesis
RL Nucleic Acids Res. 23:1311-1318 (1995).
RN [6]; RE0010509.
RX PUBMED: 7891708.
RA Galson D. L., Tsuchiya T., Tendler D. S., Huang L. E., Ren Y., Ogura T., Bunn H. F.
RT The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1
RL Mol. Cell. Biol. 15:2135-2144 (1995).
RN [7]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [8]; RE0014411.
RX PUBMED: 8505324.
RA Rottman J. N., Gordon J. I.
RT Comparison of the patterns of expression of rat intestinal fatty acid binding protein/human growth hormone fusion genes in cultured intestinal epithelial cell lines and in the gut epithelium of transgenic mice
RL J. Biol. Chem. 268:11994-12002 (1993).
RN [9]; RE0016808.
RX PUBMED: 9461615.
RA Vorgia P., Zannis V. I., Kardassis D.
RT A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different binding specificities for orphan receptors HNF-4, ARP-1, and EAR-2.
RL J. Biol. Chem. 273:4188-4196 (1998).
RN [10]; RE0016834.
RX PUBMED: 11085951.
RA McNair A., Cereghini S., Brand H., Smith T., Breillat C., Gannon F.
RT Synergistic activation of the Atlantic salmon hepatocyte nuclear factor (HNF) 1 promoter by the orphan nuclear receptors HNF4 and chicken ovalbumin upstream promoter transcription factor I (COUP-TFI).
RL Biochem. J. 352:557-564 (2000).
RN [11]; RE0016841.
RX PUBMED: 10627496.
RA Stroup D., Chiang J. Y.
RT HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
RL J. Lipid Res. 41:1-11 (2000).
RN [12]; RE0018030.
RX PUBMED: 10098492.
RA Robinson C. E., Wu X., Nawaz Z., Onate S. A., Gimble J. M.
RT A corepressor and chicken ovalbumin upstream promoter transcriptional factor proteins modulate peroxisome proliferator-activated receptor-gamma2/retinoid X receptor alpha-activated transcription from the murine lipoprotein lipase promoter.
RL Endocrinology 140:1586-1593 (1999).
RN [13]; RE0035108.
RX PUBMED: 11544252.
RA Liberati C., Cera M. R., Secco P., Santoro C., Mantovani R., Ottolenghi S., Ronchi A.
RT Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters.
RL J. Biol. Chem. 276:41700-41709 (2001).
RN [14]; RE0035110.
RX PUBMED: 9927428.
RA Filipe A., Li Q., Deveaux S., Godin I., Romeo P. H., Stamatoyannopoulos G., Mignotte V.
RT Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching.
RL EMBO J. 18:687-697 (1999).
RN [15]; RE0074469.
RX PUBMED: 22693611.
RA Litchfield L. M., Riggs K. A., Hockenberry A. M., Oliver L. D., Barnhart K. G., Cai J., Pierce WM J. r., Ivanova M. M., Bates P. J., Appana S. N., Datta S., Kulesza P., McBryan J., Young L. S., Klinge C. M.
RT Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor beta transcription in breast cancer cells.
RL PLoS ONE 7:e38278 (2012).
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