AC T02137
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ID T02137
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DT 23.05.1997 (created); hiwi.
DT 11.09.2013 (updated); spk.
CO Copyright (C), QIAGEN.
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FA PC4
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SY p14; p15; PC4; positive cofactor 4.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006537 SUB1; HGNC: SUB1.
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HO SUB1 (yeast).
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SF binds to single- and double-stranded DNA [3] [5];
SF interacts with TBP-TFIIA complexes, but not with TBP alone [3];
SF bipartite domain structure of an N-terminal regulatory and a C-terminal cryptic DNA-binding domain [4];
SF similar serine-rich regions which are followed by short acidic stretches have been found in several viral transcription regulators (IE62 of Varizella-Zoster, ICP4 and IE180 of HSV-1) [4];
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FF coactivator, mediating effects of upstream activators to the general transcription machinery [3] [4];
FF interacting with acidic activation domains, both acting together to enhance TFIIA-TFIID-promoter complexes [3] [5];
FF binding to double-stranded DNA and transcription activation are negatively regulated by serine phosphorylation within the regulatory domain, apparently by casein kinase II (CKII) [2] [4] [5];
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IN T18829 cdc5L; human, Homo sapiens.
IN T00045 COUP-TF2; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T00819 Sua7p; yeast, Saccharomyces cerevisiae.
IN T00794 TBP; human, Homo sapiens.
IN T00817 TFIIA; human, Homo sapiens.
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DR TRANSPATH: MO000026187.
DR UniProtKB: P53999;
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RN [1]; RE0005547.
RX PUBMED: 1889091.
RA Meisterernst M., Roy A. L., Lieu H. M., Roeder R. G.
RT Activation of class II gene transcription by regulatory factors is potentiated by a novel activity
RL Cell 66:981-993 (1991).
RN [2]; RE0005616.
RX PUBMED: 7809103.
RA Ge H., Zhao Y., Chait B. T., Roeder R. G.
RT Phosphorylation negatively regulates the function of coactivator PC4
RL Proc. Natl. Acad. Sci. USA 91:12691-12695 (1994).
RN [3]; RE0005617.
RX PUBMED: 8062391.
RA Ge H., Roeder R. G.
RT Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes
RL Cell 78:513-523 (1994).
RN [4]; RE0005619.
RX PUBMED: 8062392.
RA Kretzschmar M., Kaiser K., Lottspeich F., Meisterernst M.
RT A novel mediator of class I gene transcription with homology to viral immediate-early transcriptional regulators
RL Cell 78:525-534 (1994).
RN [5]; RE0005621.
RX PUBMED: 7628453.
RA Kaiser K., Stelzer G., Meisterernst M.
RT The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation
RL EMBO J. 14:3520-3527 (1995).
RN [6]; RE0047883.
RX PUBMED: 14966284.
RA Banerjee S., Kumar B. R., Kundu T. K.
RT General transcriptional coactivator PC4 activates p53 function.
RL Mol. Cell. Biol. 24:2052-2062 (2004).
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