TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00794 XX ID T00794 XX DT 27.01.1993 (created); hse. DT 13.08.2015 (updated); jmh. CO Copyright (C), QIAGEN. XX FA TBP XX SY TATA-binding protein; TATA-box-binding protein; TBP; TFIID; TFIIDtau. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004647 TBP; HGNC: TBP. XX CL C0082; TATA; XX SF conserved C-terminal part, 88% identity with Drosophila and 80% identity with yeast TBP [11] [23]; SF some homology with bacterial IHFs with the two direct repeats within the conserved part [34]; SF the divergent N-terminal part is required for TATA-containing pol II and pol III promoters, but not for TATA-less or pol I promoters [29]; SF in mutually exclusive association with distinct sets of TAFs, it is part of TFIID, SL1, and TFIIIB [30] [38] [39] [40] [17]; SF binds to DNA as a monomer; SF bends DNA [20]; SF DNA-bnding stability is enhanced by TFIIA [8]; SF interaction with TAF(II)250 correlates with ability to mediate activation by upstream factors [41]; SF the amino-terminal 204 aa of the c-Myc proteins interact directly with the TFP-protein [51]; SF binding consensus determined by REPSA experiment: TATAAATA [52]; XX CP ubiquitous; SK-N-SH cells, HeLa cells and a lower ratio in HEK293 cells [61]. XX FF required for transcription by polymerase I, II, and III [4]; FF basal transcription by pol II is mediated by TBP, upstream activator effects by TBP-TAF(II) complexes (TFIID); FF alone functional on TATA-containing pol III promoters, on TATA-less pol III promoters only as B-TFIID complex of TBP with a 170-kDa component not found in larger TFIID complexes (D-TFIID) [17]; FF activity is regulated by competitive binding between positively (e. g., TFIIA) and negatively acting factors (e. g., NC2, NC1) [33] [8]; FF competitive TATA-box binding with TMF (TATA element modulatory factor) T00835 [21]; FF cellular poliovirus infection causes proteolytic degradation of TBP by viral protease 3C [36]; XX IN T28731 AUF1; human, Homo sapiens. IN T08474 beta-catenin-isoform1; human, Homo sapiens. IN T17899 BRF-1; human, Homo sapiens. IN T00068 Brf1p; yeast, Saccharomyces cerevisiae. IN T00168 c-Rel; human, Homo sapiens. IN T00108 C/EBPalpha-isoform1; rat, Rattus norvegicus. IN T14184 Cdx-1; mouse, Mus musculus. IN T19899 CXXC1; human, Homo sapiens. IN T00182 DBF4; human, Homo sapiens. IN T00209 E1A 13S protein; adenovirus type 2. IN T01542 E2F-1; human, Homo sapiens. IN T04365 GF14; thale cress, Arabidopsis thaliana. IN T00530 NC1; human, Homo sapiens. IN T00197 NC2; human, Homo sapiens. IN T00647 Oct-2; human, Homo sapiens. IN T01427 p300; human, Homo sapiens. IN T00671 p53; human, Homo sapiens. IN T13888 pax6; Mammalia. IN T02137 PC4; human, Homo sapiens. IN T00641 POU2F1-isoform1; human, Homo sapiens. IN T01508 PTF; human, Homo sapiens. IN T01683 PTFbeta; human, Homo sapiens. IN T01681 PTFdelta; human, Homo sapiens. IN T01680 PTFgamma; human, Homo sapiens. IN T02068 PU.1-isoform1; human, Homo sapiens. IN T00702 PU.1; mouse, Mus musculus. IN T00703 PU.1; chick, Gallus gallus. IN T00759 Sp1; human, Homo sapiens. IN T00819 Sua7p; yeast, Saccharomyces cerevisiae. IN T02133 TAF(I)110-xbb1; human, Homo sapiens. IN T02135 TAF(I)48; human, Homo sapiens. IN T02134 TAF(I)63; human, Homo sapiens. IN T18598 TAF-172; human, Homo sapiens. IN T00787 TAF-L; human, Homo sapiens. IN T02116 TAF2J; human, Homo sapiens. IN T01268 Taf4p; yeast, Saccharomyces cerevisiae. IN T00784 TAFII100; human, Homo sapiens. IN T00779 TAFII125; human, Homo sapiens. IN T02328 TAFII135; human, Homo sapiens. IN T28810 TAFII135; human, Homo sapiens. IN T02117 TAFII18; human, Homo sapiens. IN T00781 TAFII250-isoform2; human, Homo sapiens. IN T02114 TAFII28; human, Homo sapiens. IN T02118 TAFII30; human, Homo sapiens. IN T02113 TAFII31; human, Homo sapiens. IN T00783 TAFII70-alpha; human, Homo sapiens. IN T09103 TAFII70; human, Homo sapiens. IN T02224 TFIIA-gamma; human, Homo sapiens. IN T00817 TFIIA; human, Homo sapiens. IN T00818 TFIIB; human, Homo sapiens. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). IN T00894 Vmw65; HSV-1, herpes simplex virus type 1. IN T00923 Zta; EBV, Epstein-Barr virus. XX MX M00252 V$TATA_01. MX M00216 V$TATA_C. MX M00471 V$TBP_01. MX M04880 V$TBP_08. MX M04915 V$TBP_09. MX M00980 V$TBP_Q6. MX M03581 V$TBP_Q6_01. XX BS R02688. BS R00998. BS R01001. BS R03702. BS R03703. BS R23229. BS R04803. BS R03182. BS R00705. BS R03701. BS R29191. BS R64808. BS R37627. BS R37628. BS R37629. BS R38432. BS R42009. BS R72635. BS R72640. BS R72645. BS R72649. BS R03158. BS R03167. BS R38937. BS R29199. BS R00770. BS R65916. BS R67219. BS R32347. BS R18813. BS R62311. BS R61672. BS R21393. BS R37634. BS R37637. BS R37638. BS R03171. BS R61368. BS R23228. BS R03160. BS R69240. BS R03159. BS R14711. BS R70549. BS R03157. BS R02247. XX DR TRANSPATH: MO000021896. DR UniProtKB: P20226; XX RN [1]; RE0000184. RX PUBMED: 1913802. RA Greenblatt J. RT Roles of TFIID in transcriptional initiation by RNA polymerase II RL Cell 66:1067-1070 (1991). RN [2]; RE0000220. RX PUBMED: 1458533. RA Taggart A. K. P., Fisher T. S., Pugh B. F. RT The TATA-binding protein and associated factors are components of pol III transcription factor TFIIIB RL Cell 71:1015-1028 (1992). RN [3]; RE0000221. RX PUBMED: 1458534. RA Lobo S. M., Tanaka M., Sullivan M. L., Hernandez N. RT A TBP complex essential for transcription from TATA-less but not TATA-containing RNA polymerase III promoters is part of the TFIIIB fraction RL Cell 71:1029-1040 (1992). RN [4]; RE0000748. RX PUBMED: 1869050. RA Lobo S. M., Lister J., Sullivan M. L., Hernandez N. RT The cloned RNA polymerase II transcription factor IID selects RNA polymerase III to transcribe the human U6 gene in vitro RL Genes Dev. 5:1477-1489 (1991). RN [5]; RE0000749. RX PUBMED: 1936986. RA Timmers H. T. M., Sharp P. A. RT The mammalian TFIID protein is present in two functionally distinct complexes RL Genes Dev. 5:1946-1956 (1991). RN [6]; RE0000750. RX PUBMED: 1661258. RA Lieberman P. M., Berk A. J. RT The Zta trans-activator protein stabilizes TFIID association with promoter DNA by direct protein-protein interaction RL Genes Dev. 5:2441-2454 (1991). RN [7]; RE0000875. RX PUBMED: 3818643. RA Reinberg D., Horikoshi M., Roeder R. G. RT Factors involved in specific transcription by mammalian RNA polymerase II. Functional analysis of initiation factors IIA and IID and identification of a new factor operating at sequences downstream of the initiation site RL J. Biol. Chem. 262:3322-3330 (1987). RN [8]; RE0000975. RX PUBMED: 8428901. RA Truant R., Xiao H., Ingles C. J., Greenblatt J. RT Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein RL J. Biol. Chem. 268:2284-2287 (1993). RN [9]; RE0000976. RX PUBMED: 2040615. RA Safer B., Reinberg D., Jacob W. F., Maldonado E., Carcamo J., Garfinkel S., Cohen R. RT Interaction of CAP sequence site binding factor and transcription factor IID preceding and following binding to the adenovirus 2 major late promoter RL J. Biol. Chem. 266:10989-10994 (1991). RN [10]; RE0001544. RX PUBMED: 2247058. RA Maldonado E., Ha I., Cortes P., Weis L., Reinberg D. RT Factors involved in specific Transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-component complex RL Mol. Cell. Biol. 10:6335-6347 (1990). RN [11]; RE0001879. RX PUBMED: 2374612. RA Hoffmann A., Sinn E., Yamamoto T., Wang J., Roy A., Horikoshi M., Roeder R. G. RT Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID) RL Nature 346:387-390 (1990). RN [12]; RE0001880. RX PUBMED: 2234067. RA Nakatani Y., Horikoshi M., Brenner M., Yamamoto T., Besnard F., Roeder R. G., Freese E. RT A downstream initiation element required for efficient TATA box binding and in vitro function of TFIID RL Nature 348:86-88 (1990). RN [13]; RE0001882. RX PUBMED: 2193231. RA Stringer K. F., Ingles C. J., Greenblatt J. RT Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID RL Nature 345:783-786 (1990). RN [14]; RE0001933. RX PUBMED: 2156167. RA Wefald F. C., Devlin B. H., Williams S. RT Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer RL Nature 344:260-262 (1990). RN [15]; RE0002100. RX PUBMED: 1861978. RA Tamura T., Sumita K., Fujino I., Aoyama A., Horikoshi M., Hoffmann A., Roeder R. G., Muramatsu M., Mikoshiba K. RT Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID) RL Nucleic Acids Res. 19:3861-3865 (1991). RN [16]; RE0002493. RX PUBMED: 8434021. RA Hagemeier C., Bannister A. J., Cook A., Kouzarides T. RT The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB RL Proc. Natl. Acad. Sci. USA 90:1580-1584 (1993). RN [17]; RE0002495. RX PUBMED: 1387711. RA Timmers H. T. M., Meyers R. E., Sharp P. A. RT Composition of transcription factor B-TFIID RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992). RN [18]; RE0002496. RX PUBMED: 1321424. RA Wiley S. R., Kraus R. J., Mertz J. E. RT Functional binding of the TATA box binding component of transcription factor TFIID to the -30 region of TATA-less promoters RL Proc. Natl. Acad. Sci. USA 89:5814-5818 (1992). RN [19]; RE0002500. RX PUBMED: 2251259. RA Kambadur R., Culotta V., Hamer D. RT Cloned yeast and mammalian transcription factor TFIID gene products support basal but not activated metallothionein gene transcription RL Proc. Natl. Acad. Sci. USA 87:9168-9142 (1990). RN [20]; RE0002501. RX PUBMED: 1736286. RA Horikoshi M., Bertuccioli C., Takada R., Wang C. K., Yamamoto T., Roeder R. G. RT Transcription factor TFIID induces DNA bending upon binding to the TATA element RL Proc. Natl. Acad. Sci. USA 89:1060-1064 (1992). RN [21]; RE0002502. RX PUBMED: 1409643. RA Garcia J. A., Ou S.-H. I., Wu F., Lusis A. J., Sparkes R. S., Gaynor R. B. RT Cloning and chromosomal mapping of a human immunodeficiency virus 1 TATA element modulatory factor RL Proc. Natl. Acad. Sci. USA 89:9372-9376 (1992). RN [22]; RE0002685. RX PUBMED: 2194289. RA Kao C. C., Liebermann P. M., Schmidt M. C., Zhou Q., Pei R., Berk A. J. RT Cloning of a transcriptionally active human TATA binding factor RL Science 248:1646-1650 (1990). RN [23]; RE0002686. RX PUBMED: 2363050. RA Peterson M. G., Tanese N., Pugh B. F., Tjian R. RT Functional domains and upstream activation properties of cloned human TATA binding protein RL Science 248:1625-1630 (1990). RN [24]; RE0002756. RX PUBMED: 2192257. RA van Dyke M. W., Sawadogo M. RT DNA-binding and transcriptional properties of human transcription factor TFIID after mild proteolysis RL Mol. Cell. Biol. 10:3415-3420 (1990). RN [25]; RE0004129. RX PUBMED: 1909174. RA Zhu H., Roy A. L., Roeder R. G., Prywes R. RT Serum response factor affects preinitiation complex formation by TFIID in vitro RL New Biol. 3:455-464 (1991). RN [26]; RE0005387. RX PUBMED: 8405994. RA Chen X., Farmer G., Zhu H., Prywes R., Prives C. RT Cooperative DNA binding of p53 TFIID (TBP): a possible mechanism for transcriptional activation RL Genes Dev. 7:1837-1849 (1993). RN [27]; RE0005389. RX PUBMED: 8514746. RA Martin D. W., Munoz R. M., Subler M. A., Deb S. RT p53 binds to the TATA-binding protein-TATA complex RL J. Biol. Chem. 268:13062-13067 (1993). RN [28]; RE0005457. RX PUBMED: 8497252. RA Liu X., Miller C. W., Koeffler P. H., Berk A. J. RT The p53 activation domain binds the TATA box-binding polypeptide in holo-TFIID, and a neighboring p53 domain inhibits transcription RL Mol. Cell. Biol. 13:3291-3300 (1993). RN [29]; RE0005505. RX PUBMED: 7510635. RA Lescure A., Lutz Y., Eberhard D., Jacq X., Krol A., Grummt I., Davidson I., Chambon P., Tora L. RT The N-terminal domain of the human TATA-binding protein plays a role in transcription from TATA-containing RNA polymerase II and III promoters RL EMBO J. 13:1166-1175 (1994). RN [30]; RE0005506. RX PUBMED: 7801123. RA Comai L., Zomerdijk J. C. B. M., Beckmann H., Zhou S., Admon A., Tjian R. RT Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits RL Science 266:1966-1972 (1994). RN [31]; RE0005507. RX PUBMED: 8758937. RA Dubrovskaya V., Lavigne A.-C., Davidson I., Acker J., Staub A., Tora L. RT Distinct domains of hTAFII100 are requireed for functional interactions with transcription factor TFIIbeta (RAP30) and incorporation into the TFIID complex RL EMBO J. 15:3702-3712 (1996). RN [32]; RE0005546. RX PUBMED: 1833071. RA Lee W. S., Kao C. C., Bryant G. O., Liu X., Berk A. J. RT Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor RL Cell 67:365-376 (1991). RN [33]; RE0005547. RX PUBMED: 1889091. RA Meisterernst M., Roy A. L., Lieu H. M., Roeder R. G. RT Activation of class II gene transcription by regulatory factors is potentiated by a novel activity RL Cell 66:981-993 (1991). RN [34]; RE0005548. RX PUBMED: 1760837. RA Nash H. A., Granston A. E. RT Similarity between the DNA-binding domains of IHF protein and TFIID protein RL Cell 67:1037-1038 (1991). RN [35]; RE0005549. RX PUBMED: 1310667. RA Kelleher III R. J., Flanagan P. M., Chasman D. I., Ponticelli A. S., Struhl K., Kornberg R. D. RT Yeast and human TFIIDs are interchangeable for the response to acidic transcriptional activators in vitro RL Genes Dev. 6:296-303 (1992). RN [36]; RE0005550. RX PUBMED: 8380894. RA Clark M. E., Lieberman P. M., Berk A. J., Dasgupta A. RT Direct cleavage of human TATA-binding protein by poliovirus protease 3C in vivo and in vitro RL Mol. Cell. Biol. 13:1232-1237 (1993). RN [37]; RE0005551. RX PUBMED: 8440239. RA Brou C., Chaudhary S., Davidson I., Lutz Y., Wu J., Egly J.-M., Tora L., Chambon P. RT Distinct TFIID complexes mediate the effect of different transcriptional activators RL EMBO J. 12:489-499 (1993). RN [38]; RE0005552. RX PUBMED: 7687540. RA Chiang C.-M., Ge H., Wang Z., Hoffmann A., Roeder R. G. RT Unique TATA-binding protein-containing complexes and cofactors involved in transcription by RNA polymerases II and III RL EMBO J. 12:2749-2762 (1993). RN [39]; RE0005553. RX PUBMED: 8422684. RA Rigby P. W. J. RT Three in one and one in three: it all depends on TBP RL Cell 72:7-10 (1993). RN [40]; RE0005554. RX PUBMED: 1297645. RA White R. J., Rigby P. W. J., Jackson S. P. RT The TATA-binding protein is a general transcription factor for RNA polymerase III RL Cell 103:1-7 (1992). RN [41]; RE0005555. RX PUBMED: 7958931. RA Tansey W. P., Ruppert S., Tjian R., Herr W. RT Multiple regions of TBP participate in the response to transcriptional activators in vivo RL Genes Dev. 8:2756-2769 (1994). RN [42]; RE0005556. RX PUBMED: 8191287. RA Rowlands T., Baumann P., Jackson S. P. RT The TATA-binding protein: a general transcription factor in eukaryotes and archaebacteria RL Science 264:1326-1329 (1994). RN [43]; RE0005557. RX PUBMED: 1657708. RA Pugh B. F., Tjian R. RT Transcription from a TATA-less promoter requires a multisubunit TFIID complex RL Genes Dev. 5:1935-1945 (1991). RN [44]; RE0005558. RX PUBMED: 7440579. RA Segall J., Matsui T., Roeder R. G. RT Mutiple factors are required for the accurate transcription of purified genes by RNA polymerase III RL J. Biol. Chem. 255:11986-11991 (1980). RN [45]; RE0005559. RX PUBMED: 8436290. RA Zhou Q., Boyer T. G., Berk A. J. RT Factors (TAFs) required for activated transcription interact with TATA box-binding protein conserved core domain RL Genes Dev. 7:180-187 (1993). RN [46]; RE0005560. RX PUBMED: 8262073. RA Weinzierl R. O. J., Ruppert S., Dynlacht B. D., Tanese N., Tjian R. RT Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID RL EMBO J. 12:5303-5309 (1993). RN [47]; RE0005561. RX PUBMED: 1547496. RA Comai L., Tanese N., Tjian R. RT The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1 RL Cell 68:965-976 (1992). RN [48]; RE0005562. RX PUBMED: 7923369. RA Jacq X., Brou C., Lutz Y., Davidson I., Chambon P., Tora L. RT Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor RL Cell 79:107-117 (1994). RN [49]; RE0010487. RX PUBMED: 7739551. RA Naidu P. S., Ludolph D. C., To R. Q., Hinterberger T. J., Konieczny S. F. RT Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis RL Mol. Cell. Biol. 15:2707-2718 (1995). RN [50]; RE0013514. RX PUBMED: 9171375. RA Wang Z., Roeder R. G. RT Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. RL Genes Dev. 11:1315-1326 (1997). RN [51]; RE0014660. RX PUBMED: 7690963. RA Hateboer G., Timmers H. T. M., Rustgi A. K., Billaud M., van't Veer L. J., Bernards R. RT TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein RL Proc. Natl. Acad. Sci. USA 90:8489-8493 (1993). RN [52]; RE0016807. RX PUBMED: 9241250. RA Hardenbol P., Wang J. C., van Dyke M. W. RT Identification of preferred hTBP DNA binding sites by the combinatorial method REPSA RL Nucleic Acids Res. 25:3339-3344 (1997). RN [53]; RE0046907. RX PUBMED: 9334239. RA Surinya K. H., Cox T. C., May B. K. RT Transcriptional regulation of the human erythroid 5-aminolevulinate synthase gene. Identification of promoter elements and role of regulatory proteins RL J. Biol. Chem. 272:26585-94 (1997). RN [54]; RE0047312. RX PUBMED: 10591646. RA Andel F. 3rd, Ladurner A. G., Inouye C., Tjian R., Nogales E. RT Three-dimensional structure of the human TFIID-IIA-IIB complex RL Science 286:2153-6 (1999). RN [55]; RE0047734. RX PUBMED: 9388200. RA Leveillard T., Wasylyk B. RT The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter. RL J. Biol. Chem. 272:30651-30661 (1997). RN [56]; RE0047797. RX PUBMED: 15923621. RA Mialon A., Sankinen M., Soderstrom H., Junttila T. T., Holmstrom T., Koivusalo R., Papageorgiou A. C., Johnson R. S., Hietanen S., Elenius K., Westermarck J. RT DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. RL Mol. Cell. Biol. 25:5040-5051 (2005). RN [57]; RE0048103. RX PUBMED: 11903055. RA Tolnay M., Juang Y. T., Tsokos G. C. RT Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion. RL Biochem. J. 363:127-136 (2002). RN [58]; RE0048297. RX PUBMED: 10359315. RA Cvekl A., Kashanchi F., Brady J. N., Piatigorsky J. RT Pax-6 interactions with TATA-box-binding protein and retinoblastoma protein. RL Invest. Ophthalmol. Vis. Sci. 40:1343-1350 (1999). RN [59]; RE0048322. RX PUBMED: 15899866. RA Frontini M., Soutoglou E., Argentini M., Bole-Feysot C., Jost B., Scheer E., Tora L. RT TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. RL Mol. Cell. Biol. 25:4638-4649 (2005). RN [60]; RE0049299. RX PUBMED: 12379483. RA Qadri I., Iwahashi M., Simon F. RT Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3. RL Biochim. Biophys. Acta 1592:193-204 (2002). RN [61]; RE0050400. RX PUBMED: 15767669. RA Chong J. A., Moran M. M., Teichmann M., Kaczmarek J. S., Roeder R., Clapham D. E. RT TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. RL Mol. Cell. Biol. 25:2632-2643 (2005). RN [62]; RE0052321. RX PUBMED: 17158164. RA Calon A., Gross I., Davidson I., Kedinger M., Duluc I., Domon-Dell C., Freund J. N. RT Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein. RL Nucleic Acids Res. 35:175-185 (2007). RN [63]; RE0072503. RX PUBMED: 20840866. RA Simoneau M., Coulombe G., Vandal G., Vezina A., Rivard N. RT SHP-1 inhibits beta-catenin function by inducing its degradation and interfering with its association with TATA-binding protein. RL Cell. Signal. 23:269-279 (2011). XX //