TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00197 XX ID T00197 XX DT 14.04.1993 (created); ewi. DT 19.11.2007 (updated); djp. CO Copyright (C), QIAGEN. XX FA NC2 XX SY DBF2; Dr1; NC2; negative cofactor 2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004660 DR1; HGNC: Dr1. XX SF phosphorylation, potential phosphorylation sites for PKA, PKC, CKII; SF HAP2-homologous N-terminus (31%); SF Q/A-rich region exerts some homology with Krueppel, Even-skipped, and Engrailed proteins [1]; SF interaction between NC2 and the AREB6 T00625 repression domain [7]; XX FF transcription repressor, binds to TBP and competitively inhibits TBP-TFIIA-interaction when phosphorylated thereby suppressing core promoter activity (e.g., HIV-1 promoter) [3] [2]; FF represses pol II and pol III, but not pol I [5]; XX IN T08562 CREB1; human, Homo sapiens. IN T19100 NC2alpha; human, Homo sapiens. IN T10617 NF-YC; human, Homo sapiens. IN T00794 TBP; human, Homo sapiens. IN T00796 TBP; mouse, Mus musculus. IN T00625 ZEB (1124 AA); human, Homo sapiens. XX BS R03156. XX DR TRANSPATH: MO000024764. DR UniProtKB: Q01658; TBAP_HUMAN. XX RN [1]; RE0000217. RX PUBMED: 1339312. RA Inostroza J. A., Mermelstein F. H., Ha I., Lane W. S., Reinberg D. RT Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription RL Cell 70:477-489 (1992). RN [2]; RE0000229. RX PUBMED: 1934060. RA Meisterernst M., Roeder R. G. RT Family of proteins that interact with TFIID and regulate promoter activity RL Cell 67:557-567 (1991). RN [3]; RE0000746. RX PUBMED: 1398073. RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J. RT Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter RL Genes Dev. 6:1964-1974 (1992). RN [4]; RE0005518. RX PUBMED: 7738039. RA Kim T. K., Zhao Y., Ge H., Bernstein R., Roeder R. G. RT TATA-binding protein residues implicated in a functional interplay between negative cofactor NC2(Dr1) and general factors TFIIA and TFIIB RL J. Biol. Chem. 270:10976-10981 (1995). RN [5]; RE0005613. RX PUBMED: 7939686. RA White R. J., Khop B. C.-E., Inostroza J. A., Reinberg D., Jackson S. P. RT Differential regulation of RNA Polymerase I, II and III by the TBP-binding repressor Dr1 RL Science 266:448-450 (1994). RN [6]; RE0005614. RX PUBMED: 8022773. RA Kraus V. B., Inostroza J. A., Yeung K., Reinberg D., Nevins J. R. RT Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A RL Proc. Natl. Acad. Sci. USA 91:6279-6282 (1994). RN [7]; RE0015154. RX PUBMED: 9418848. RA Ikeda K., Halle J. P., Stelzer G., Meisterernst M., Kawakami K. RT Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6 RL Mol. Cell. Biol. 18:10-18 (1998). XX //