AC T08562
XX
ID T08562
XX
DT 10.02.2006 (created); vma.
DT 28.04.2016 (updated); mka.
CO Copyright (C), QIAGEN.
XX
FA CREB1
XX
SY ATF-47; CREB; CREB1; cyclic AMP response element-binding protein; Cyclic AMP Responsive Element Binging factor; X2-box binding protein; X2BP.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004624 CREB1; HGNC: CREB1.
XX
CL C0008; bZIP; 1.1.7.1.1.
XX
FF Treatment with forskolin increases the transcriptional enhancement of the Pen2 G006959 promoter. [32];
FF cPKA increased the amount of phospho-CREB comparatively with forskolin treated cells [15];
XX
IN T09069 ATF-1-isoform1; human, Homo sapiens.
IN T10136 ATF-2; human, Homo sapiens.
IN T04742 ATF-6; human, Homo sapiens.
IN T18797 ATFa; human, Homo sapiens.
IN T10523 c-Ets-2; human, Homo sapiens.
IN T00133 c-Jun; human, Homo sapiens.
IN T18378 CBP; human, Homo sapiens.
IN T18883 CREM-Ia; human, Homo sapiens.
IN T18884 CREM-Ib; human, Homo sapiens.
IN T09588 E4BP4; human, Homo sapiens.
IN T01113 Elf-1; human, Homo sapiens.
IN T08475 GR-alpha; rat, Rattus norvegicus.
IN T18885 ICER-xbb1; human, Homo sapiens.
IN T18835 Mi2-alpha; human, Homo sapiens.
IN T00197 NC2; human, Homo sapiens.
IN T22515 POGZ; human, Homo sapiens.
IN T00641 POU2F1-isoform1; human, Homo sapiens.
IN T08949 PXR; human, Homo sapiens.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
IN T01560 SREBP-2; human, Homo sapiens.
IN T16642 TFIIA-alpha/beta precursor; human, Homo sapiens.
IN T31844 topoisomerase-II-alpha; human, Homo sapiens.
IN T08239 TORC1; human, Homo sapiens.
IN T22521 TOX4; human, Homo sapiens.
IN T04355 zhx1; human, Homo sapiens.
IN T19500 ZN451; human, Homo sapiens.
XX
MX M02279 V$CREB1_01.
MX M07248 V$CREB1_Q3.
MX M03544 V$CREB1_Q6.
MX M00981 V$CREBATF_Q6.
MX M00039 V$CREB_01.
MX M00113 V$CREB_02.
MX M00177 V$CREB_Q2.
MX M00916 V$CREB_Q2_01.
MX M00801 V$CREB_Q3.
MX M00178 V$CREB_Q4.
MX M00917 V$CREB_Q4_01.
MX M00114 V$TAXCREB_01.
MX M00115 V$TAXCREB_02.
XX
BS R16162.
BS R28031.
BS R39219.
BS R63767.
BS R63768.
BS R63776.
BS R63778.
BS R37582.
BS R31160.
BS R33982.
BS R25014.
BS R40322.
BS R21774.
BS R24714.
BS R31372.
BS R12540.
BS R25010.
BS R25053.
BS R32997.
BS R59341.
BS R59342.
BS R59343.
BS R59344.
BS R59345.
BS R59347.
BS R59348.
BS R59349.
BS R28673.
BS R20975.
BS R66083.
BS R57383.
BS R66306.
BS R66308.
BS R23184.
BS R62897.
BS R68781.
BS R35029.
BS R34533.
BS R58480.
BS R67792.
BS R29920.
BS R13381.
BS R29945.
BS R27566.
BS R27567.
BS R71059.
BS R38041.
BS R34860.
BS R60518.
BS R23883.
BS R37692.
BS R31326.
BS R24841.
BS R16774.
BS R16776.
BS R61834.
BS R23289.
BS R62927.
BS R66854.
BS R55820.
BS R35321.
BS R36325.
BS R00471.
BS R68201.
BS R68208.
BS R60961.
BS R71366.
BS R71367.
BS R71368.
BS R61233.
BS R69581.
BS R32700.
BS R36615.
BS R31350.
BS R31351.
BS R27588.
BS R20613.
BS R37619.
BS R37620.
BS R60700.
BS R60712.
BS R60720.
BS R32731.
BS R32733.
BS R39945.
BS R41052.
BS R66950.
BS R63829.
BS R29836.
BS R37867.
BS R26804.
BS R31705.
BS R31707.
BS R41736.
BS R23890.
BS R23927.
BS R25287.
BS R33536.
BS R60806.
BS R34064.
BS R34395.
BS R42133.
BS R38316.
BS R19543.
BS R42045.
BS R32328.
BS R37555.
BS R38327.
BS R29660.
BS R69343.
BS R73765.
BS R73766.
BS R60005.
BS R70158.
BS R70162.
BS R73019.
BS R73020.
BS R40627.
BS R63045.
BS R40077.
BS R42183.
BS R60297.
BS R34194.
BS R34236.
BS R42075.
BS R42076.
BS R22580.
BS R33673.
BS R70538.
BS R34122.
BS R23170.
BS R72473.
BS R61321.
BS R61322.
BS R61324.
BS R60588.
BS R27212.
BS R56943.
BS R61805.
BS R59174.
BS R64466.
BS R21070.
BS R59927.
BS R32876.
BS R70465.
BS R70466.
BS R34292.
BS R21486.
BS R71058.
BS R31001.
BS R30422.
BS R30423.
BS R30425.
BS R32798.
BS R34698.
BS R34843.
BS R65946.
BS R30898.
BS R72717.
BS R73035.
BS R34179.
BS R29252.
BS R59021.
BS R21255.
BS R34562.
BS R38122.
BS R32085.
BS R27268.
BS R69566.
BS R69576.
BS R64947.
BS R64948.
BS R64949.
BS R59146.
BS R25204.
BS R24499.
BS R59366.
BS R21738.
BS R38767.
BS R41147.
BS R23164.
BS R65082.
BS R40042.
BS R25226.
BS R40194.
BS R59753.
BS R38970.
BS R32817.
BS R34301.
BS R56223.
BS R55825.
BS R31839.
BS R33512.
BS R24961.
BS R73701.
BS R01215.
BS R39002.
BS R62894.
BS R62895.
BS R27577.
BS R09520.
XX
DR TRANSPATH: MO000060543.
DR TRANSCOMPEL: C00530.
DR UniProtKB: P16220;
XX
RN [1]; RE0024467.
RX PUBMED: 12944398.
RA Huber W. E., Price E. R., Widlund H. R., Du J., Davis I. J., Wegner M., Fisher D. E.
RT A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes.
RL J. Biol. Chem. 278:45224-45230 (2003).
RN [2]; RE0033804.
RX PUBMED: 15294971.
RA Takeshita F., Suzuki K., Sasaki S., Ishii N., Klinman D. M., Ishii K. J.
RT Transcriptional regulation of the human TLR9 gene.
RL J. Immunol. 173:2552-61 (2004).
RN [3]; RE0047117.
RX PUBMED: 15923627.
RA Chakrabarti K., Lin R., Schiller N. I., Wang Y., Koubi D., Fan Y. X., Rudkin B. B., Johnson G. R., Schiller M. R.
RT Critical role for Kalirin in nerve growth factor signaling through TrkA
RL Mol. Cell. Biol. 25:5106-18 (2005).
RN [4]; RE0047173.
RX PUBMED: 15466214.
RA Unni E., Sun S., Nan B., McPhaul M. J., Cheskis B., Mancini M. A., Marcelli M.
RT Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence
RL Cancer Res. 64:7156-68 (2004).
RN [5]; RE0047203.
RX PUBMED: 11874984.
RA Cristillo A. D., Highbarger H. C., Dewar R. L., Dimitrov D. S., Golding H., Bierer B. E.
RT Up-regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP-responsive element
RL FASEB J. 16:354-64 (2002).
RN [6]; RE0047223.
RX PUBMED: 15994978.
RA Du B., Altorki N. K., Kopelovich L., Subbaramaiah K., Dannenberg A. J.
RT Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism
RL Cancer Res. 65:5982-8 (2005).
RN [7]; RE0047872.
RX PUBMED: 9685505.
RA Yamaguchi Y., Wada T., Suzuki F., Takagi T., Hasegawa J., Handa H.
RT Casein kinase II interacts with the bZIP domains of several transcription factors.
RL Nucleic Acids Res. 26:3854-3861 (1998).
RN [8]; RE0047941.
RX PUBMED: 8387155.
RA Kroll D. J., Sullivan D. M., Gutierrez-Hartmann A., Hoeffler J. P.
RT Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine-3',5'-monophosphate response element-binding protein and related transcription factors.
RL Mol. Endocrinol. 7:305-318 (1993).
RN [9]; RE0048013.
RX PUBMED: 15691881.
RA Kim J., Jia L., Stallcup M. R., Coetzee G. A.
RT The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus.
RL J. Mol. Endocrinol. 34:107-118 (2005).
RN [10]; RE0048279.
RX PUBMED: 15637148.
RA Ghosh D., Sachdev S., Hannink M., Roberts R. M.
RT Coordinate regulation of basal and cyclic 5'-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-alpha by Ets-2 and cAMP-responsive element binding protein.
RL Mol. Endocrinol. 19:1049-1066 (2005).
RN [11]; RE0048287.
RX PUBMED: 12805554.
RA Newman J. R., Keating A. E.
RT Comprehensive identification of human bZIP interactions with coiled-coil arrays.
RL Science 300:2097-2101 (2003).
RN [12]; RE0048396.
RX PUBMED: 16818466.
RA Presnell S. R., Zhang L., Ramilo C. A., Chan H. W., Lutz C. T.
RT Functional redundancy of transcription factor-binding sites in the killer cell Ig-like receptor (KIR) gene promoter.
RL Int. Immunol. 18:1221-1232 (2006).
RN [13]; RE0049641.
RX PUBMED: 15695103.
RA Long A. A., Chapman N. R., Innes B., Europe-Finner G. N., Robson S. C.
RT Expression and interaction of the transcriptional coregulators, CBP/p300, in the human myometrium during pregnancy and labor.
RL J. Soc. Gynecol. Invest. 12:92-97 (2005).
RN [14]; RE0049979.
RX PUBMED: 15073328.
RA Shi Y., Venkataraman S. L., Dodson G. E., Mabb A. M., LeBlanc S., Tibbetts R. S.
RT Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.
RL Proc. Natl. Acad. Sci. USA 101:5898-5903 (2004).
RN [15]; RE0050263.
RX PUBMED: 8999953.
RA Ying L., Morris B. J., Sigmund C. D.
RT Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells.
RL J. Biol. Chem. 272:2412-2420 (1997).
RN [16]; RE0062522.
RX PUBMED: 16713974.
RA Hu X., Paik P. K., Chen J., Yarilina A., Kockeritz L., Lu T. T., Woodgett J. R., Ivashkiv L. B.
RT IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.
RL Immunity 24:563-574 (2006).
RN [17]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
RN [18]; RE0063969.
RX PUBMED: 19428786.
RA Hutchinson A. J., Chou C. L., Israel D. D., Xu W., Regan J. W.
RT Activation of EP2 prostanoid receptors in human glial cell lines stimulates the secretion of BDNF.
RL Neurochem. Int. 54:439-446 (2009).
RN [19]; RE0064069.
RX PUBMED: 12630910.
RA Watanabe Y., Song T., Sugimoto K., Horii M., Araki N., Tokumitsu H., Tezuka T., Yamamoto T., Tokuda M.
RT Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase.
RL Biochem. J. 372:465-471 (2003).
RN [20]; RE0064466.
RX PUBMED: 16740657.
RA Zbytek B., Wortsman J., Slominski A.
RT Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes.
RL Mol. Endocrinol. 20:2539-2547 (2006).
RN [21]; RE0065050.
RX PUBMED: 19937254.
RA Mizutani Y., Hayashi N., Kawashima M., Imokawa G.
RT A single UVB exposure increases the expression of functional KIT in human melanocytes by up-regulating MITF expression through the phosphorylation of p38/CREB.
RL Arch. Dermatol. Res. 302:283-294 (2009).
RN [22]; RE0065170.
RX PUBMED: 11591753.
RA Gubina E., Luo X., Kwon E., Sakamoto K., Shi Y. F., Mufson R. A.
RT betac cytokine receptor-induced stimulation of cAMP response element binding protein phosphorylation requires protein kinase C in myeloid cells: a novel cytokine signal transduction cascade.
RL J. Immunol. 167:4303-4310 (2001).
RN [23]; RE0065432.
RX PUBMED: 11841550.
RA Tada A., Pereira E., Beitner-Johnson D., Kavanagh R., Abdel-Malek Z. A.
RT Mitogen- and ultraviolet-B-induced signaling pathways in normal human melanocytes.
RL J. Invest. Dermatol 118:316-322 (2002).
RN [24]; RE0065576.
RX PUBMED: 19651774.
RA Hansen C., Howlin J., Tengholm A., Dyachok O., Vogel W. F., Nairn A. C., Greengard P., Andersson T.
RT Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner.
RL J. Biol. Chem. 284:27533-27543 (2009).
RN [25]; RE0065709.
RX PUBMED: 18039926.
RA Sato-Jin K., Nishimura E. K., Akasaka E., Huber W., Nakano H., Miller A., Du J., Wu M., Hanada K., Sawamura D., Fisher D. E., Imokawa G.
RT Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders.
RL FASEB J. 22:1155-1168 (2008).
RN [26]; RE0067572.
RX PUBMED: 18854309.
RA Denison F. C., Hiscock N. J., Carling D., Woods A.
RT Characterization of an alternative splice variant of LKB1.
RL J. Biol. Chem. 284:67-76 (2009).
RN [27]; RE0068873.
RX PUBMED: 14962944.
RA Rius J., Martinez-Gonzalez J., Crespo J., Badimon L.
RT Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB.
RL Arterioscler. Thromb. Vasc. Biol. 24:697-702 (2004).
RN [28]; RE0069214.
RX PUBMED: 8854242.
RA Evans D. B., Hipskind R. A., Bilbe G.
RT Analysis of signaling pathways used by parathyroid hormone to activate the c-fos gene in human SaOS2 osteoblast-like cells.
RL J. Bone Miner. Res. 11:1066-1074 (1996).
RN [29]; RE0070919.
RX PUBMED: 20573984.
RA Sakamoto K., Huang B. W., Iwasaki K., Hailemariam K., Ninomiya-Tsuji J., Tsuji Y.
RT Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.
RL Mol. Biol. Cell 21:2966-2974 (2010).
RN [30]; RE0071171.
RX PUBMED: 16007092.
RA Martin M., Rehani K., Jope R. S., Michalek S. M.
RT Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.
RL Nat. Immunol. 6:777-784 (2005).
RN [31]; RE0072606.
RX PUBMED: 21262972.
RA Chen H., Liu L., Ma B., Ma T. M., Hou J. J., Xie G. M., Wu W., Yang F. Q., Chen Y. G.
RT Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation.
RL J. Biol. Chem. 286:14870-14880 (2011).
RN [32]; RE0049822.
RX PUBMED: 16449647.
RA Wang R., Zhang Y. W., Sun P., Liu R., Zhang X., Zhang X., Xia K., Xia J., Xu H., Zhang Z.
RT Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB.
RL Mol. Cell. Biol. 26:1347-1354 (2006).
XX
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