AC T08239
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ID T08239
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DT 06.10.2005 (created); elf.
DT 29.01.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA TORC1
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SY CREB regulated transcription coactivator 1; Crtc1; FLJ14027; KIAA0616; MECT1; mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1; Transducer of CREB protein 1; Transducer of regulated cAMP response element-binding protein 1; WAMTP1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G021420 CRTC1; HGNC: Crtc1.
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CP abundant in certain regions of the brain (prefrontal cortex, cerebellum) [1].
EX cerebellum,,,adult; very high; RT-PCR; total RNA; [1].
EX cerebral cortex,,,adult; very high; RT-PCR; total RNA; [1].
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FF coactivator [1];
FF TORC1 complex activates the IL-8 promoter through a CRE-site [2];
FF transducer of regulated CREB activity [1];
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IN T00163 CREB-A; human, Homo sapiens.
IN T08562 CREB1; human, Homo sapiens.
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BS R18283.
BS R18285.
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DR TRANSPATH: MO000056458.
DR UniProtKB: Q6UUV9; MECT1_HUMAN.
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RN [1]; RE0035549.
RX PUBMED: 14536081.
RA Conkright M. D., Canettieri G., Screaton R., Guzman E., Miraglia L., Hogenesch J. B., Montminy M.
RT TORCs: transducers of regulated CREB activity.
RL Mol. Cell 12:413-423 (2003).
RN [2]; RE0035550.
RX PUBMED: 14506290.
RA Iourgenko V., Zhang W., Mickanin C., Daly I., Jiang C., Hexham J. M., Orth A. P., Miraglia L., Meltzer J., Garza D., Chirn G. W., McWhinnie E., Cohen D., Skelton J., Terry R., Yu Y., Bodian D., Buxton F. P., Zhu J., Song C., Labow M. A.
RT Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.
RL Proc. Natl. Acad. Sci. USA 100:12147-12152 (2003).
RN [3]; RE0067513.
RX PUBMED: 16980408.
RA Wu Z., Huang X., Feng Y., Handschin C., Feng Y., Gullicksen P. S., Bare O., Labow M., Spiegelman B., Stevenson S. C.
RT Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.
RL Proc. Natl. Acad. Sci. USA 103:14379-14384 (2006).
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