TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00641 XX ID T00641 XX DT 15.10.1992 (created); ewi. DT 04.03.2015 (updated); pos. CO Copyright (C), QIAGEN. XX FA POU2F1-isoform1 XX SY (Ig)NF-A; alpha-H1; NF-A1; NF-III; OBP100; Oct-1; Oct-1B; oct-B1A; oct-B1B; octamer-binding factor; OTF-1; POU domain, class 2, transcription factor 1; POU2F1; TRF. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G005327 POU2F1; HGNC: POU2F1. XX CL C0007; POU; XX SZ 743 AA; 76.5 kDa (cDNA) (calc.), 90, 92, 95 kDa (SDS) XX SQ MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS SQ LQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQ SQ LLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQ SQ QLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLQTQLPQQSQANLLQSQ SQ PSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRI SQ KLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDS SQ SLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK SQ EVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP SQ VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA SQ SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP SQ SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV SQ FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ SQ NSLFTVASASGAASTTTTASKAQ XX SC Swiss-Prot#P14859-1 XX FT 280 354 PF00157; Pou domain - N-terminal to homeobox domain. FT 280 354 SM00352; pou. FT 281 438 interaction with Stat5A [85]. FT 354 704 PF00478; IMP dehydrogenase / GMP reductase domain. FT 377 437 PS50071; HOMEOBOX_2. FT 377 439 PS50550; POU_HOMEODOMAIN. FT 379 441 SM00389; HOX_1. FT 380 436 PF00046; Homeobox domain. XX SF alternative splice variants [52]; SF the bipartite DNA-binding (POU) domain comprises a POU-specific (POUs) and a POU homeo (POUh) domain [30]; SF the homeo domain contains a recognizable helix-turn-helix motif [80] [30] [16]; SF the POU-specific domain comprises 4 alpha-helices connected by short loops, forming an internal hydrophobic core and representing an extended helix-turn-helix motif; SF helix 1 and 4 form a parallel coiled coil, helix 3 acts as recognition helix and is part of a structure that resembles that of bacteriophage repressors [77] [78] [80]; SF POUs contacts the 5'-half of the canonical ATGCAAAT, POUh the 3'-half [61] [80]; SF although not directly interacting within the molecule, POUs, POUh and the linker region in between together define the DNA-binding specificity of the whole POU domain [70] [80]; SF POUs induces DNA-bending [14]; SF KD for the canonical octamer element is 0.1 nM, whereas binding to the unrelated heptamer element (CTCATGA) has a KD of 20 nM [71]; SF interaction of two POU domains causes cooperative binding to adjacent octamer and heptamer elements [71]; SF another pattern recognized by Oct-1 is TAATGARAT, e. g. in the IE genes of HSV-1, frequently overlapping an octamer element [44] [8]; SF at this sequence, the complex depends on an intact POUh domain and also involves a viral activator (VP16) and one or two cellular components (C1 / HCF, C2) [61] [62]; SF in TAATGARAT, POUh contacts the 5'-half, the viral and/or C1 the 3'-half and 3' adjacent sequences [22] [62] [83] [13]; SF other reports describe the 3'-half to be contacted by the POUs domain with both POUs and POUh binding to DNA in the reverse order than on the normal octamer element [54]; SF this emphasizes the importance of the linker flexibility between POUs and POUh [55] [80]; SF only at the TAATGARAT element, Oct-1 adopts the conformation that is suitable for VP16 interaction, through POUh helix 1 and 2 with Glu-400 discriminating against Oct-2 [73] [74] [76] [81]; SF glutamine-rich N-terminal trans-activation domain [60]; SF transcriptionally inert C-terminus (contrasting to Oct-2) [60]; SF the second Glu-rich region activates only from binding sites that are proximal to the TATA box / initiation site [72]; SF direct interaction of POU with the C-terminal core domain of TBP [82]; XX CP ubiquitous [16]. XX FF transcriptional activator in the pol II and in the pol III system [58] [17]; FF also part of the replication machinery of adenovirus [48]; FF for stimulation of replication, the DNA-binding domain (whole POU domain) is required (POUs is inert, POUh inhibitory) and sufficient [10]; FF cooperative effects with Sp1, PR and/or GR, OAP40 [66] [68] [84]; FF differentially phosphorylated during cell cycle, possibly by a p34cdc2-related protein kinase during mitosis with concomitant activation of histone H2B gene [60] [64] [50]; FF mitosis-specific phosphorylation within the POUh domain at Ser-385 is achieved in vitro by PKA and inhibits DNA-binding [64]; FF down-regulated by IFN-alpha or by TPA [65]; FF in response to PRL or TPO-stimulation, STAT5 can bind to the Oct-GAS2 site in the cyclin D1 gene, if POU2F1-isoform1 is present [85]; XX IN T10237 ATF-1; Mammalia. IN T01030 CCF; human, Homo sapiens. IN T08562 CREB1; human, Homo sapiens. IN T09920 CREB1; Mammalia. IN T02184 cyclinH; human, Homo sapiens. IN T00118 HCF1-isoform1; human, Homo sapiens. IN T02187 MAT1; human, Homo sapiens. IN T02186 MO15; human, Homo sapiens. IN T02141 OCA-B; human, Homo sapiens. IN T00649 Oct-2; cat, Felis silvestris catus. IN T00650 Oct-2; rat, Rattus rattus. IN T08433 RXR-alpha; human, Homo sapiens. IN T01578 STAT5A; sheep, Ovis aries. IN T01579 STAT5A; mouse, Mus musculus. IN T04683 STAT5A; human, Homo sapiens. IN T04684 STAT5B; human, Homo sapiens. IN T00794 TBP; human, Homo sapiens. IN T02183 TFIIH-p62; human, Homo sapiens. IN T02181 TFIIH-p90; human, Homo sapiens. IN T00894 Vmw65; HSV-1, herpes simplex virus type 1. XX MX M00135 V$OCT1_01. MX M00136 V$OCT1_02. MX M00137 V$OCT1_03. MX M00138 V$OCT1_04. MX M00161 V$OCT1_05. MX M00162 V$OCT1_06. MX M00248 V$OCT1_07. MX M01354 V$OCT1_08. MX M00342 V$OCT1_B. MX M00930 V$OCT1_Q5_01. MX M00195 V$OCT1_Q6. MX M00210 V$OCT_C. MX M00795 V$OCT_Q6. MX M07058 V$POU2F1_Q4. MX M07059 V$POU2F1_Q4_01. MX M03561 V$POU2F1_Q6. XX BS R01177. BS R01176. BS R01989. BS R02001. BS R03333. BS R03334. BS R03335. BS R04676. BS R00664. BS R03010. BS R08237. BS R08238. BS R15742. BS R28361. BS R00549. BS R00551. BS R00557. BS R04196. BS R04197. BS R04200. BS R04201. BS R00662. BS R00833. BS R01635. BS R01638. BS R00932. BS R00936. BS R05055. BS R05056. BS R14543. BS R15352. BS R09467. BS R04234. BS R02571. BS R18415. BS R01500. BS R00810. BS R01917. BS R00812. BS R02732. BS R02733. BS R00814. BS R00815. BS R00820. BS R00824. BS R01734. BS R00838. BS R00842. BS R00843. BS R00869. BS R00872. BS R01682. BS R00888. BS R00890. BS R00891. BS R00892. BS R00893. BS R01778. BS R01779. BS R01780. BS R03426. BS R03427. BS R02953. BS R03383. BS R13571. BS R02225. BS R04594. BS R04595. BS R04602. BS R04708. BS R04726. BS R04727. BS R04728. BS R00666. BS R03417. BS R03418. BS R03419. BS R03420. BS R05017. BS R15482. BS R01388. BS R01389. BS R01396. BS R01399. BS R01400. BS R01401. BS R01504. XX DR TRANSPATH: MO000035093. DR TRANSCOMPEL: C00169. DR TRANSCOMPEL: C00365. DR TRANSCOMPEL: C00424. DR EMBL: BC001664; DR EMBL: BC003571; DR EMBL: BC052274; DR EMBL: S75007; S75007. DR EMBL: X13403; HSOCT1. DR UniProtKB: P14859-1; DR PDB: 1pog. XX RN [1]; RE0000078. RX PUBMED: 3677172. RA Fletcher C., Heintz N., Roeder R. G. RT Purification and Characterization of OTF-1, a Transcription Factor Regulating Cell Cycle Expression of a Human Histone H2b Gene RL Cell 51:773-781 (1987). RN [2]; RE0000085. RX PUBMED: 2830987. RA O'Hare P., Goding C. R. RT Herpes Simplex Virus Regulatory Elements and the Immunoglobulin Octamer Domain Bind a Common Factor and Are Both Targets for Virion Transactivation RL Cell 52:435-445 (1988). RN [3]; RE0000087. RX PUBMED: 2830986. RA Preston C. M., Frame M. C., Campbell M. E. M. RT A Complex formed between Cell Components and an HSV Structural Polypeptide Binds to a Viral Immediate Early Gene Regulatory DNA Sequence RL Cell 52:425-434 (1988). RN [4]; RE0000088. RX PUBMED: 3091258. RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). RN [5]; RE0000094. RX PUBMED: 3119226. RA Scheidereit C., Heguy A., Roeder R. G. RT Identification and Purification of a Human Lymphoid-Specific Octamer-Binding Protein (OTF-2) That Activates Transcription of an Immunoglobulin Promoter In Vitro RL Cell 51:783-793 (1987). RN [6]; RE0000316. RX PUBMED: 3428274. RA Pruijn G. J. M., van Driel W., van Miltenburg R. T., van der Vliet P. C. RT Promoter and enhancer elements containing a conserved sequence motif are recognized by nuclear factor III, a protein stimulating adenovirus DNA replication RL EMBO J. 6:3771-3778 (1987). RN [7]; RE0000352. RX PUBMED: 2507313. RA Kemler I., Schreiber E., Mueller M. M., Matthias P., Schaffner W. RT Octamer transcription factors bind to two different sequence motifs of the heavy chain promoter RL EMBO J. 8:2001-2008 (1989). RN [8]; RE0000368. RX PUBMED: 2826126. RA Xiao J. H., Davidson I., Ferrandon D., Rosales R., Vigneron M., Macchi M., Ruffenach F., Chambon P. RT One cell-specific and three ubiquitous proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer RL EMBO J. 6:3005-3013 (1987). RN [9]; RE0000369. RX PUBMED: 3072196. RA Schreiber E., Matthias P., Mueller M. M., Schaffner W. RT Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA) RL EMBO J. 7:4221-4229 (1988). RN [10]; RE0000390. RX PUBMED: 2347308. RA Verrijzer C. P., Kal A. J., van der Vliet P. C. RT The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication RL EMBO J. 9:1883-1888 (1990). RN [11]; RE0000405. RX PUBMED: 2826127. RA Rosales R., Vigneron M., Macchi M., Davidson I., Xiao J. H., Chambon P. RT In vitro binding of cell-specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancers RL EMBO J. 6:3015-3025 (1987). RN [12]; RE0000424. RX PUBMED: 2573524. RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P. RT Octamer binding proteins confer transcriptional activity in early mouse embryogenesis RL EMBO J. 8:2551-2557 (1989). RN [13]; RE0000429. RX PUBMED: 2556266. RA Kristie T. M., LeBovitz J. H., Sharp P. A. RT The octamer-binding proteins form multi-protein-DNA complexes with the HSV alphaTIF regulatory protein RL EMBO J. 8:4229-4238 (1989). RN [14]; RE0000528. RX PUBMED: 1915275. RA Verrijzer C. P., van Oosterhout J. A. W. M., van Weperen W. W., van der Vliet P. C. RT POU proteins bend DNA via the POU-specific domain RL EMBO J. 10:3007-3014 (1991). RN [15]; RE0000592. RX PUBMED: 2850260. RA Baumruker T., Sturm R., Herr W. RT OBP100 binds remarkably degenerate octamer motifs through specific interactions with flanking sequences RL Genes Dev. 2:1400-1413 (1988). RN [16]; RE0000605. RX PUBMED: 2905684. RA Sturm R. A., Das G., Herr W. RT The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain RL Genes Dev. 2:1582-1599 (1988). RN [17]; RE0000606. RX PUBMED: 3264542. RA LeBowitz J. H., Kobayashi T., Staudt L., Baltimore D., Sharp P. A. RT Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitro RL Genes Dev. 2:1227-1237 (1988). RN [18]; RE0000608. RX PUBMED: 2828167. RA Sturm R., Baumruker T., Franza jr B. R., Herr W. RT A 100-kD HeLa cell octamer binding protein (OBP100) interacts differently with two separate octamer-related sequences within the SV40 enhancer RL Genes Dev. 1:1147-1160 (1987). RN [19]; RE0000814. RX PUBMED: 2826468. RA O'Neill E. A., Kelly T. J. RT Purification and Characterization of Nuclear Factor III (Origin Recognition Protein C), a Sequence-specific DNA Binding Protein Required for Efficient Initiation of Adenovirus DNA Replication RL J. Biol. Chem. 263:931-937 (1988). RN [20]; RE0001160. RX PUBMED: 2214023. RA Mul Y. M., Verrijzer C. P., van der Vliet P. C. RT Transcription factors NFI and NFIII/oct-1 function independently, employing different mechanisms to enhance adenovirus DNA replication RL J. Virol. 64:5510-5518 (1990). RN [21]; RE0001180. RX PUBMED: 1645782. RA Spector D., Purves F., Roizman B. RT Role of alpha-transducing factor (VP16) in the induction of alpha genes within the context of viral genomes RL J. Virol. 65:3504-3513 (1991). RN [22]; RE0001182. RX PUBMED: 1658370. RA Greaves R. F., O'Hare P. RT Sequence, function, and regulation of the Vmw65 gene of herpes simplex virus type 2 RL J. Virol. 65:6705-6713 (1991). RN [23]; RE0001291. RX PUBMED: 2710122. RA Poellinger L., Roeder R. G. RT Octamer transcription factors 1 and 2 each bind to two different functional elements in the immunoglobulin heavy-chain promoter RL Mol. Cell. Biol. 9:747-756 (1989). RN [24]; RE0001313. RX PUBMED: 2851727. RA Stimac E., Lyons S., Pious D. RT Transcription of HLA Class II Genes in the Absence of B-Cell-Specific Octamer-Binding Factor RL Mol. Cell. Biol. 8:3734-3739 (1988). RN [25]; RE0001367. RX PUBMED: 2113179. RA Nelms K., van Ness B. RT Identification of an Octamer-Binding Site in the Human Kappa Light-Chain Enhancer RL Mol. Cell. Biol. 10:3843-3846 (1990). RN [26]; RE0001368. RX PUBMED: 2109186. RA Martin D. J., van Ness B. G. RT Initiation and Processing of Two Kappa Immunoglobulin Germ Line Transcripts in Mouse B Cells RL Mol. Cell. Biol. 10:1950-1958 (1990). RN [27]; RE0001404. RX PUBMED: 2511430. RA Currie R. A., Roeder R. G. RT Identification of an Octamer-Binding Site in the Mouse Kappa Light-Chain Immunoglobulin Enhancer RL Mol. Cell. Biol. 9:4239-4247 (1989). RN [28]; RE0001488. RX PUBMED: 2204815. RA Kamps M. P., Corcoran L., LeBowitz J. H., Baltimore D. RT The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2 RL Mol. Cell. Biol. 10:5464-5472 (1990). RN [29]; RE0001599. RX PUBMED: 1996097. RA Zhou D.-X., Yen T. S. B. RT The ubiquitous transcription factor Oct-1 and the liver-specific factor HNF-1 are both required to activate transcription of a hepatitis B virus promoter RL Mol. Cell. Biol. 11:1353-1359 (1991). RN [30]; RE0001795. RX PUBMED: 2904656. RA Sturm R. A., Herr W. RT The POU domain is a bipartite DNA-binding structure RL Nature 336:601-604 (1988). RN [31]; RE0001797. RX PUBMED: 2571937. RA Stern S., Tanaka M., Herr W. RT The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16 RL Nature 341:624-630 (1989). RN [32]; RE0001800. RX PUBMED: 3095662. RA Staudt L. M., Singh H., Sen R., Wirth T., Sharp P. A., Baltimore D. RT A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes RL Nature 323:640-643 (1986). RN [33]; RE0001803. RX PUBMED: 3027566. RA Bohmann D., Keller W., Dale T., Schoeler H. R., Tebb G., Mattaj I. W. RT A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes RL Nature 325:268-272 (1987). RN [34]; RE0001955. RX PUBMED: 2928110. RA Pruijn G. J. M., van der Vliet P. C., Dathan N. A., Mattaj I. W. RT Anti-OTF-1 antibodies inhibit NFIII stimulation of in vitro adenovirus DNA replication RL Nucleic Acids Res. 17:1845-1863 (1989). RN [35]; RE0001981. RX PUBMED: 2734104. RA Catala F., deBoer E., Habets G., Grosveld F. RT Nuclear protein factors and erythroid transcription of the human Agamma-globin gene RL Nucleic Acids Res. 17:3811-3827 (1989). RN [36]; RE0001982. RX PUBMED: 2922260. RA Broggini M., Ponti M., Ottolenghi S., D'Incalci M., Mongelli N., Mantovani R. RT Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their conserved DNA elements RL Nucleic Acids Res. 17:1051-1059 (1989). RN [37]; RE0001983. RX PUBMED: 2458563. RA Mantovani R., Malgarettie N., Nicolis S., Ronchi A., Giglioni B., Ottolenghi S. RT The effects of HPFH mutations in the human gamma-globin promoter on binding of ubiquitous and erythroid specific nuclear factors RL Nucleic Acids Res. 16:7783-7797 (1988). RN [38]; RE0001995. RX PUBMED: 3122182. RA Wang J., Nishiyama K., Araki K., Kitamura D., Watanabe T. RT Purification of an octamer sequence (ATGCAAAT)-binding protein from human B cells RL Nucleic Acids Res. 15:10105-10116 (1987). RN [39]; RE0002050. RX PUBMED: 2472607. RA Lloyd J. A., Lee R. F., Lingrel L. B. RT Mutations in two regions upstream of the Agamma globin gene canonical promoter affect gene expression RL Nucleic Acids Res. 17:4339-4352 (1989). RN [40]; RE0002056. RX PUBMED: 2555786. RA Shibuya H., Taniguchi T. RT Identification of multiple cis-elements and trans-acting factors involved in the induced expression of human IL-2 gene RL Nucleic Acids Res. 17:9173-9184 (1989). RN [41]; RE0002148. RX PUBMED: 2175881. RA Katan M., Haigh A., Verrijzer C. P., van der Vliet P. C., O'Hare P. RT Characterization of a cellular factor which interacts functionally with Oct-1 in the assembly of a multicomponent transcription complex RL Nucleic Acids Res. 18:6871-6880 (1990). RN [42]; RE0002172. RX PUBMED: 1909431. RA Hoegbom E., Magnusson A.-C., Leanderson T. RT Functional modularity in the SP6 kappa promoter RL Nucleic Acids Res. 19:4347-4354 (1991). RN [43]; RE0002297. RX PUBMED: 3462701. RA Sive H. L., Roeder R. G. RT Interaction of a common factor with conserved promoter and enhancer sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) genes RL Proc. Natl. Acad. Sci. USA 83:6382-6386 (1986). RN [44]; RE0002310. RX PUBMED: 2842768. RA Gerster T., Roeder R. G. RT A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins RL Proc. Natl. Acad. Sci. USA 85:6347-6351 (1988). RN [45]; RE0002311. RX PUBMED: 3025864. RA Kristie T. M., Roizman B. RT Host cell proteins bind to the cis-acting site required for virion-mediated induction of herpes simplex virus 1 alpha genes RL Proc. Natl. Acad. Sci. USA 84:71-75 (1987). RN [46]; RE0002312. RX PUBMED: 2823252. RA McKnight J. L. C., Kristie T. M., Roizman B. RT Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins RL Proc. Natl. Acad. Sci. USA 84:7061-7065 (1987). RN [47]; RE0002612. RX PUBMED: 3399892. RA Staudt L. M., Clerc R. G., Singh H., LeBowitz J. H., Sharp P. A., Baltimore D. RT Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif RL Science 241:577-580 (1988). RN [48]; RE0002623. RX PUBMED: 3413485. RA O'Neill E. A., Fletcher C., Burrow C. R., Heintz N., Roeder R. G., Kelly T. J. RT Transcription factor OTF-1 is functionally identical to the DNA replication factor NF-III RL Science 241:1210-1213 (1988). RN [49]; RE0002650. RX PUBMED: 2237431. RA Ho I.-C., Bhat N. K., Gottschalk L. R., Lindsten R., Thompson C. B., Papas T. S., Leiden J. M. RT Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer RL Science 250:814-818 (1990). RN [50]; RE0002655. RX PUBMED: 1887216. RA Roberts S. B., Segil N., Heintz N. RT Differential phosphorylation of the transcription factor Oct1 during cell cycle RL Science 253:1022-1026 (1991). RN [51]; RE0002767. RX PUBMED: 2109187. RA Yoza B. K., Roeder R. G. RT Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2 RL Mol. Cell. Biol. 10:2145-2153 (1990). RN [52]; RE0004180. RX PUBMED: 8227066. RA Das G., Herr W. RT Enhanced activation of the human histone H2B promoter by an Oct-1 variant generated by alternative splicing RL J. Biol. Chem. 268:25026-25032 (1993). RN [53]; RE0004182. RX PUBMED: 8454622. RA Kristie T. M., Sharp P. A. RT Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16) RL J. Biol. Chem. 268:6525-6534 (1993). RN [54]; RE0004183. RX PUBMED: 7891704. RA Cleary M. A., Herr W. RT Mechanisms for flexibility in DNA sequence recognition and VP16-induced complex formation by the Oct-1 POU domain RL Mol. Cell. Biol. 15:2090-2100 (1995). RN [55]; RE0004184. RX PUBMED: 7622033. RA Herr W., Cleary M. A. RT The POU domain: versatility in tanscriptional regulation by a flexible two-in-one DNA-binding domain RL Genes Dev. 9:1679-1693 (1995). RN [56]; RE0004186. RX PUBMED: 1970171. RA Goldsborough A., Ashworth A., Willison K. R. RT Cloning and sequencing of POU-boxes expressed in mouse testis RL Nucleic Acids Res. 18:1634-1634 (1990). RN [57]; RE0004189. RX PUBMED: 1762932. RA Sturm R. A. RT An STS in the human oct-1 gene located on chromosome 1 RL Nucleic Acids Res. 19:6963-6963 (1991). RN [58]; RE0004192. RX PUBMED: 2532066. RA Murphy S., Pierani A., Scheidereit C., Melli L., Roeder R. G. RT Purified octamer binding transcription factors stimulate RNA polymerase III-mediated transcription of the 7SK RNA gene RL Cell 59:1071-1080 (1989). RN [59]; RE0004193. RX PUBMED: 2167442. RA Xiao P., Capone J. P. RT A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1 RL Mol. Cell. Biol. 10:4974-4977 (1990). RN [60]; RE0004194. RX PUBMED: 2302733. RA Tanaka M., Herr W. RT Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation RL Cell 60:375-386 (1990). RN [61]; RE0004195. RX PUBMED: 1980478. RA Verrijzer C. P., Kal A. J., van der Vliet P. C. RT The oct-1 homeo domain contacts only part of the octamer sequence and full oct-1 DNA-binding activity requires the POU-specific domain RL Genes Dev. 4:1964-1974 (1990). RN [62]; RE0004196. RX PUBMED: 1980658. RA Kristie T. M., Sharp P. A. RT Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV a-trans-activator protein RL Genes Dev. 4:2382-2396 (1990). RN [63]; RE0004197. RX PUBMED: 1650186. RA Dent C. L., Latchman D. S. RT The overlapping octamer/TAATGARAT motif is a high-affinity binding site for the cellular transcription factors Oct-1 and Oct-2 RL Biochem. J. 277:541-545 (1991). RN [64]; RE0004198. RX PUBMED: 1684878. RA Segil N., Roberts S. B., Heintz N. RT Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity RL Science 254:1814-1816 (1991). RN [65]; RE0004199. RX PUBMED: 1939139. RA Dent C. L., Lillycrop K. A., Bybee A., Latchman D. S., Thomas N. S. B. RT Interferon-a treatment of Daudi cells down-regulates the octamer binding transcription/DNA replication factors Oct-1 and Oct-2 RL J. Biol. Chem. 266:20888-20892 (1991). RN [66]; RE0004200. RX PUBMED: 2191301. RA Janson L., Petersson U. RT Cooperative interactions between transcription factors Sp1 and OTF-1 RL Proc. Natl. Acad. Sci. USA 87:4732-4736 (1990). RN [67]; RE0004202. RX PUBMED: 1684335. RA Stern S., Herr W. RT The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain RL Genes Dev. 5:2555-2566 (1991). RN [68]; RE0004203. RX PUBMED: 1683003. RA Ullman K. S., Flanagan W. M., Edwards C. A., Crabtree G. R. RT Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40 RL Science 254:558-562 (1991). RN [69]; RE0004204. RX PUBMED: 1739980. RA Tanaka M., Lai J.-S., Herr W. RT Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter RL Cell 68:755-767 (1992). RN [70]; RE0004205. RX PUBMED: 1732727. RA Aurora R., Herr W. RT Segments of the POU domain influence one another's DNA-binding specificity RL Mol. Cell. Biol. 12:455-467 (1992). RN [71]; RE0004206. RX PUBMED: 1346336. RA Verrijzer C. P., van Oosterhout J. A. W. M., van der Vliet P. C. RT The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins RL Mol. Cell. Biol. 12:542-551 (1992). RN [72]; RE0004207. RX PUBMED: 1464321. RA Seipel K., Georgiev O., Schaffner W. RT Different activation domains stimulte transcription from remote ('enhancer') and proximal ('promoter') positions RL EMBO J. 11:4961-4968 (1992). RN [73]; RE0004209. RX PUBMED: 1358756. RA Lai J.-S., Cleary M. A., Herr W. RT A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain RL Genes Dev. 6:2058-2065 (1992). RN [74]; RE0004210. RX PUBMED: 1358755. RA Pomerantz J. L., Kristie T. M., Sharp P. A. RT Recognition of the surface of a homeo domain protein RL Genes Dev. 6:2047-2057 (1992). RN [75]; RE0004211. RX PUBMED: 8392914. RA Wilson A. C., LaMarco K., Peterson M. G., Herr W. RT The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein RL Cell 74:115-125 (1993). RN [76]; RE0004213. RX PUBMED: 8422989. RA Cleary M. A., Stern S., Tanaka M., Herr W. RT Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment RL Genes Dev. 7:72-83 (1993). RN [77]; RE0004214. RX PUBMED: 8462099. RA Assa-Munt N., Mostishire-Smith R. J., Aurora R., Herr W., Wright P. E. RT The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage l repressor DNA-binding domain RL Cell 73:193-205 (1993). RN [78]; RE0004216. RX PUBMED: 8479524. RA Dekker N., Cox M., Boelens R., Verrijzer C. P., van der Vliet P. C. RT Solution structure of the POU-specific domain of Oct-1 RL Nature 362:852-855 (1993). RN [79]; RE0004217. RX PUBMED: 7957106. RA Coenjaerts F. E. J., van Oosterhout J. A. W. M., van der Vliet P. C. RT The Oct-1 POU domain stimulates adenovirus DNA replication by a direct interaction between the viral precursor terminal protein-DNA polymerase complex and the POU homeodomain RL EMBO J. 13:5401-5409 (1994). RN [80]; RE0004218. RX PUBMED: 8156594. RA Klemm J. D., Rould M. A., Aurora R., Herr W., Pabo C. O. RT Crytsal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules RL Cell 77:21-32 (1994). RN [81]; RE0004219. RX PUBMED: 8001121. RA Walker S., Hayes S., O'Hare P. RT Site-specific conformational alteration of the Oct-1 POU-domain-DNA complex as the basis for differential recognition by Vmw65 (VP16) RL Cell 79:841-852 (1994). RN [82]; RE0004220. RX PUBMED: 8202368. RA Zwilling S., Annweiler A., Wirth T. RT The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP RL Nucleic Acids Res. 22:1655-1662 (1994). RN [83]; RE0004222. RX PUBMED: 2556838. RA Goding C. R., O'Hare P. RT Herpes simplex virus Vmw65-octamer binding protein interaction: a paradigm for combinatorial control of transcription RL Virology 173:363-367 (1989). RN [84]; RE0016547. RX PUBMED: 1846780. RA Brueggemeier U., Kalff M., Franke S., Scheidereit C., Beato M. RT Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors. RL Cell 64:565-572 (1991). RN [85]; RE0024933. RX PUBMED: 14645506. RA Magne S., Caron S., Charon M., Rouyez M. C., Dusanter-Fourt I. RT STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression. RL Mol. Cell. Biol. 23:8934-8945 (2003). XX //