TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02186 XX ID T02186 XX DT 05.06.1997 (created); hiwi. DT 15.10.2014 (updated); spk. CO Copyright (C), QIAGEN. XX FA MO15 XX SY Cdk7; MO15; p39; p40; stk1; TFIIH-MO15. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004654 CDK7; HGNC: Cdk7. XX HO KIN28 (yeast). XX SF part of the cyclin-dependent kinase-activating kinase (CAK) subcomplex of TFIIH [1] [2]; XX FF MO15 seems to autophosphorylate and phosphorylate cyclin H and MAT in the trimeric complex CAK [6]; FF catalytic activity of the CAK complex [1] [2]; XX IN T30638 BRD4; human, Homo sapiens. IN T02184 cyclinH; human, Homo sapiens. IN T09117 E2F-1; human, Homo sapiens. IN T02853 hnRNPK; human, Homo sapiens. IN T02187 MAT1; human, Homo sapiens. IN T02186 MO15; human, Homo sapiens. IN T00719 NR1B1-isoform1; human, Homo sapiens. IN T21600 nucleolin; human, Homo sapiens. IN T00641 POU2F1-isoform1; human, Homo sapiens. IN T01330 RAR-gamma1; human, Homo sapiens. IN T02185 TFIIH-p44; human, Homo sapiens. IN T02183 TFIIH-p62; human, Homo sapiens. IN T02182 TFIIH-p80; human, Homo sapiens. IN T02181 TFIIH-p90; human, Homo sapiens. IN T31844 topoisomerase-II-alpha; human, Homo sapiens. XX DR TRANSPATH: MO000023480. DR UniProtKB: P50613; XX RN [1]; RE0005770. RX PUBMED: 8692841. RA Reardon J. T., Ge H., Gibbs E., Sancar A., Hurwitz J., Pan Z.-Q. RT Isolation and characterization of two human transcription factor IIH(TFIIH)-related complexes: ERCC2/CAK and TFIIH* RL Proc. Natl. Acad. Sci. USA 93:6482-6487 (1996). RN [2]; RE0005786. RX PUBMED: 8617234. RA Adamczewski J. P., Rossignol M., Tassan J.-P., Nigg E. A., Moncollin V., Egly J.-M. RT MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH RL EMBO J. 15:1877-1884 (1996). RN [3]; RE0006202. RX PUBMED: 8208544. RA Levedakou E. N., He M., Baptist E. W., Craven R. J., Cance W. G., Welcsh P. L., Simmons A., Naylor S. L., Leach R. J., Lewis T. B., Liu E. T. RT Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern RL Oncogene 9:1977-1988 (1994). RN [4]; RE0006203. RX PUBMED: 7936635. RA Darbon J. M., Devault A., Taviaux S., Fesquet D., Martinez A. M., Galas S., Cavadore J. C., Doree M., Blanchard J. M. RT Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase RL Oncogene 9:3127-3138 (1994). RN [5]; RE0006204. RX PUBMED: 7929589. RA Tassan J. P., Schultz S. J., Bartek J., Nigg E. A. RT Cell cycle analysis of the activity, subcellular localization and subunit composition of human CAK (CDK-activating kinase) RL J. Cell Biol. 127:467-478 (1994). RN [6]; RE0020953. RX PUBMED: 9315650. RA Lu H., Fisher R. P., Bailey P., Levine A. J. RT The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro RL Mol. Cell. Biol. 17:5923-5934 (1997). RN [7]; RE0027437. RX PUBMED: 10734072. RA Lee D. K., Duan H. O., Chang C. RT From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator. RL J. Biol. Chem. 275:9308-13 (2000). RN [8]; RE0035947. RX PUBMED: 12527756. RA Talukder A. H., Mishra S. K., Mandal M., Balasenthil S., Mehta S., Sahin A. A., Barnes C. J., Kumar R. RT MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions. RL J. Biol. Chem. 278:11676-11685 (2003). RN [9]; RE0053306. RX PUBMED: 11003668. RA Nishiwaki E., Turner S. L., Harju S., Miyazaki S., Kashiwagi M., Koh J., Serizawa H. RT Regulation of CDK7-carboxyl-terminal domain kinase activity by the tumor suppressor p16(INK4A) contributes to cell cycle regulation. RL Mol. Cell. Biol. 20:7726-7734 (2000). RN [10]; RE0054706. RX PUBMED: 10428966. RA Vandel L., Kouzarides T. RT Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase. RL EMBO J. 18:4280-4291 (1999). RN [11]; RE0023310. RX PUBMED: 10748061. RA Bastien J., Adam-Stitah S., Riedl T., Egly J. M., Chambon P., Rochette-Egly C. RT TFIIH interacts with the retinoic acid receptor gamma and phosphorylates its AF-1-activating domain through cdk7. RL J. Biol. Chem. 275:21896-21904 (2000). XX //