AC T02185
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ID T02185
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DT 05.06.1997 (created); hiwi.
DT 09.05.2006 (updated); din.
CO Copyright (C), QIAGEN.
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FA TFIIH-p44
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SY BTF2; Btf2p44; general transcription factor IIH, polypeptide 2, 44kDa; GTF2H2; p44; T-BTF2P44; TFIIH.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G014398 GTF2H2; HGNC: GTF2H2.
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HO SSL1 (yeast).
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SF part of TFIIH* subcomplex of TFIIH [3];
SF the potential zinc finger motifs are involved in mediating DNA-binding by TFIIH [6];
SF interacts with CSA (Cockayne syndrome) gene product and with CSB protein [2];
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IN T02184 cyclinH; human, Homo sapiens.
IN T02186 MO15; human, Homo sapiens.
IN T02188 TFIIH-p34; human, Homo sapiens.
IN T02183 TFIIH-p62; human, Homo sapiens.
IN T02181 TFIIH-p90; human, Homo sapiens.
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DR TRANSPATH: MO000026212.
DR UniProtKB: Q13888;
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RN [1]; RE0005732.
RX PUBMED: 8152490.
RA Drapkin R., Reardon J. T., Ansari A., Huang J.-C., Zawel L., Ahn K., Sancar A., Reinberg D.
RT Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
RL Nature 368:769-772 (1994).
RN [2]; RE0005764.
RX PUBMED: 7664335.
RA Henning K. A., Li L., Iyer N., McDaniel L. D., Reagan M. S., Legerski R., Schultz R. A., Stefanini M., Lehmann A. R., Mayne L. V., Friedberg E. C.
RT The Cockayne Syndrome Group A Gene Encodes a WD Repeat Protein That Interacts with CSB Protein and a Subunit of RNA Polymerase II TFIIH
RL Cell 82:555-564 (1995).
RN [3]; RE0005770.
RX PUBMED: 8692841.
RA Reardon J. T., Ge H., Gibbs E., Sancar A., Hurwitz J., Pan Z.-Q.
RT Isolation and characterization of two human transcription factor IIH(TFIIH)-related complexes: ERCC2/CAK and TFIIH*
RL Proc. Natl. Acad. Sci. USA 93:6482-6487 (1996).
RN [4]; RE0005773.
RX PUBMED: 1733973.
RA Flores O., Lu H., Reinberg D.
RT Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH
RL J. Biol. Chem. 267:2786-2793 (1992).
RN [5]; RE0005775.
RX PUBMED: 1529339.
RA Fischer L., Gerard M., Chalut C., Lutz Y., Humbert S., Kanno M., Chambon P., Egly J.-M.
RT Cloning of the 62-kilodalton component of basic transcription factor BTF2
RL Science 257:1392-1395 (1992).
RN [6]; RE0005779.
RX PUBMED: 8194529.
RA Humbert S., van Vuuren H., Lutz Y., Hoeijmakers J. H. J., Egly J.-M., Moncollin V.
RT p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair
RL EMBO J. 13:2393-2398 (1994).
RN [7]; RE0047702.
RX PUBMED: 12419226.
RA Bradsher J., Auriol J., Proietti De Santis L., Iben S., Vonesch J. L., Grummt I., Egly J. M.
RT CSB is a component of RNA pol I transcription.
RL Mol. Cell 10:819-829 (2002).
RN [8]; RE0023310.
RX PUBMED: 10748061.
RA Bastien J., Adam-Stitah S., Riedl T., Egly J. M., Chambon P., Rochette-Egly C.
RT TFIIH interacts with the retinoic acid receptor gamma and phosphorylates its AF-1-activating domain through cdk7.
RL J. Biol. Chem. 275:21896-21904 (2000).
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