AC T02183
XX
ID T02183
XX
DT 05.06.1997 (created); hiwi.
DT 27.11.2008 (updated); ada.
CO Copyright (C), QIAGEN.
XX
FA TFIIH-p62
XX
SY BTF2; general transcription factor IIH, polypeptide 1, 62kDa; GTF2H1; p62; TFIIH.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G003988 GTF2H1; HGNC: GTF2H1.
XX
HO TFB1 (yeast).
XX
SF pI(calc.) = 8.82 [5];
SF interacts with acidic trans-activation domains of upstream activators [2] [7];
XX
IN T01542 E2F-1; human, Homo sapiens.
IN T02187 MAT1; human, Homo sapiens.
IN T02186 MO15; human, Homo sapiens.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T00641 POU2F1-isoform1; human, Homo sapiens.
IN T00722 pRb; human, Homo sapiens.
IN T01330 RAR-gamma1; human, Homo sapiens.
IN T02188 TFIIH-p34; human, Homo sapiens.
IN T02185 TFIIH-p44; human, Homo sapiens.
IN T02181 TFIIH-p90; human, Homo sapiens.
XX
DR TRANSPATH: MO000035154.
DR UniProtKB: P32780;
XX
RN [1]; RE0005732.
RX PUBMED: 8152490.
RA Drapkin R., Reardon J. T., Ansari A., Huang J.-C., Zawel L., Ahn K., Sancar A., Reinberg D.
RT Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
RL Nature 368:769-772 (1994).
RN [2]; RE0005768.
RX PUBMED: 7724549.
RA Tong X., Drapkin R., Reinberg D., Kieff E.
RT The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2
RL Proc. Natl. Acad. Sci. USA 92:3259-3263 (1995).
RN [3]; RE0005770.
RX PUBMED: 8692841.
RA Reardon J. T., Ge H., Gibbs E., Sancar A., Hurwitz J., Pan Z.-Q.
RT Isolation and characterization of two human transcription factor IIH(TFIIH)-related complexes: ERCC2/CAK and TFIIH*
RL Proc. Natl. Acad. Sci. USA 93:6482-6487 (1996).
RN [4]; RE0005773.
RX PUBMED: 1733973.
RA Flores O., Lu H., Reinberg D.
RT Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH
RL J. Biol. Chem. 267:2786-2793 (1992).
RN [5]; RE0005775.
RX PUBMED: 1529339.
RA Fischer L., Gerard M., Chalut C., Lutz Y., Humbert S., Kanno M., Chambon P., Egly J.-M.
RT Cloning of the 62-kilodalton component of basic transcription factor BTF2
RL Science 257:1392-1395 (1992).
RN [6]; RE0005779.
RX PUBMED: 8194529.
RA Humbert S., van Vuuren H., Lutz Y., Hoeijmakers J. H. J., Egly J.-M., Moncollin V.
RT p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair
RL EMBO J. 13:2393-2398 (1994).
RN [7]; RE0005781.
RX PUBMED: 7935417.
RA Xiao H., Pearson A., Coulombe B., Truant R., Zhang S., Regier J. L., Triezenberg S. J., Reinberg D., Flores O., Ingles C. J., Greenblatt J.
RT Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53
RL Mol. Cell. Biol. 14:7013-7024 (1994).
RN [8]; RE0047702.
RX PUBMED: 12419226.
RA Bradsher J., Auriol J., Proietti De Santis L., Iben S., Vonesch J. L., Grummt I., Egly J. M.
RT CSB is a component of RNA pol I transcription.
RL Mol. Cell 10:819-829 (2002).
RN [9]; RE0054706.
RX PUBMED: 10428966.
RA Vandel L., Kouzarides T.
RT Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase.
RL EMBO J. 18:4280-4291 (1999).
RN [10]; RE0023310.
RX PUBMED: 10748061.
RA Bastien J., Adam-Stitah S., Riedl T., Egly J. M., Chambon P., Rochette-Egly C.
RT TFIIH interacts with the retinoic acid receptor gamma and phosphorylates its AF-1-activating domain through cdk7.
RL J. Biol. Chem. 275:21896-21904 (2000).
XX
//