AC T02181
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ID T02181
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DT 05.06.1997 (created); hiwi.
DT 18.02.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA TFIIH-p90
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SY ERCC3; excision repair cross complementing protein 3; p89; XPB; XPBC.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001049 ERCC3; HGNC: ERCC3.
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HO RAD25 (yeast).
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SF part of TFIIH* subcomplex of TFIIH [5];
SF along with p62, it contributes to the interaction of TFIIH with acidic trans-activation domains of upstream activators [4];
SF also mediates interaction with TFIIE [1] [2];
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FF helicase and ATPase activity [3] [8] [9];
FF identical with excision repair protein XPB/ERCC3 implicated in DNA-repair disorders xeroderma pigmentosum (XP) group B and Cockayne's syndrome [8];
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IN T02186 MO15; human, Homo sapiens.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T00641 POU2F1-isoform1; human, Homo sapiens.
IN T01330 RAR-gamma1; human, Homo sapiens.
IN T24211 Six-5; human, Homo sapiens.
IN T00822 TFIIE; human, Homo sapiens.
IN T02188 TFIIH-p34; human, Homo sapiens.
IN T02185 TFIIH-p44; human, Homo sapiens.
IN T02183 TFIIH-p62; human, Homo sapiens.
IN T02182 TFIIH-p80; human, Homo sapiens.
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DR TRANSPATH: MO000035151.
DR PATHODB: MT010867.
DR PATHODB: MT010868.
DR PATHODB: MT010871.
DR UniProtKB: P19447;
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RN [1]; RE0005732.
RX PUBMED: 8152490.
RA Drapkin R., Reardon J. T., Ansari A., Huang J.-C., Zawel L., Ahn K., Sancar A., Reinberg D.
RT Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
RL Nature 368:769-772 (1994).
RN [2]; RE0005733.
RX PUBMED: 7926747.
RA Maxon M. E., Goodrich J. A., Tjian R.
RT Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance
RL Genes Dev. 8:515-524 (1994).
RN [3]; RE0005763.
RX PUBMED: 8157004.
RA van Vuuren A. J., Vermeulen W., Ma L., Weeda G., Appeldoorn E., Jaspers N. G. J., van der Eb A. J., Bootsma D., Hoeijmakers J. H. J., Humbert S., Schaeffer L., Egly J.-M.
RT Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH)
RL EMBO J. 13:1645-1653 (1994).
RN [4]; RE0005768.
RX PUBMED: 7724549.
RA Tong X., Drapkin R., Reinberg D., Kieff E.
RT The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2
RL Proc. Natl. Acad. Sci. USA 92:3259-3263 (1995).
RN [5]; RE0005770.
RX PUBMED: 8692841.
RA Reardon J. T., Ge H., Gibbs E., Sancar A., Hurwitz J., Pan Z.-Q.
RT Isolation and characterization of two human transcription factor IIH(TFIIH)-related complexes: ERCC2/CAK and TFIIH*
RL Proc. Natl. Acad. Sci. USA 93:6482-6487 (1996).
RN [6]; RE0005773.
RX PUBMED: 1733973.
RA Flores O., Lu H., Reinberg D.
RT Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH
RL J. Biol. Chem. 267:2786-2793 (1992).
RN [7]; RE0005775.
RX PUBMED: 1529339.
RA Fischer L., Gerard M., Chalut C., Lutz Y., Humbert S., Kanno M., Chambon P., Egly J.-M.
RT Cloning of the 62-kilodalton component of basic transcription factor BTF2
RL Science 257:1392-1395 (1992).
RN [8]; RE0005776.
RX PUBMED: 8465201.
RA Schaeffer L., Roy R., Humbert S., Moncollin V., Vermeulen W., Hoeijmakers J. H. J., Chambon P., Egly J.-M.
RT DNA repair helicase: A component of BTF2 (TFIIH) basic transcription factor260
RL Science 260:58-63 (1993).
RN [9]; RE0005782.
RX PUBMED: 7937133.
RA Ma L., Siemssen E. D., Noteborn H. M., van der Eb A. J.
RT The xeroderma pigmentosum group B protein ERCC3 produced in the baculovirus system exhibits DNA helicase activity
RL Nucleic Acids Res. 22:4095-4102 (1994).
RN [10]; RE0006205.
RX PUBMED: 2167179.
RA Weeda G., van Ham R. C., Vermeulen W., Bootsma D., van der Eb A. J., Hoeijmakers J. H.
RT A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome
RL Cell 62:777-791 (1990).
RN [11]; RE0047702.
RX PUBMED: 12419226.
RA Bradsher J., Auriol J., Proietti De Santis L., Iben S., Vonesch J. L., Grummt I., Egly J. M.
RT CSB is a component of RNA pol I transcription.
RL Mol. Cell 10:819-829 (2002).
RN [12]; RE0023310.
RX PUBMED: 10748061.
RA Bastien J., Adam-Stitah S., Riedl T., Egly J. M., Chambon P., Rochette-Egly C.
RT TFIIH interacts with the retinoic acid receptor gamma and phosphorylates its AF-1-activating domain through cdk7.
RL J. Biol. Chem. 275:21896-21904 (2000).
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