AC T00822
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ID T00822
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DT 15.10.1992 (created); ewi.
DT 14.12.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA TFIIE
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SY CB; CII; epsilon (rat); TFIIE.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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SF TFIIE is a heterodimer of 34- and 56 kDa subunits [18];
SF TFIIE is a heterotetramer composed of two subunits: TFIIE-alpha T02162 and TFIIF-beta T02163 [3] [4];
SF the beta subunit first homodimerizes and associates with two alpha chains [5];
SF either TFIIE-subunit interacts with the C-terminal RNA polymerase II domain (CTD) [13];
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CP (HeLa).
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FF after RNA polymerase II has been assembled into the basal transcription complex, only holo-TFIIE enters the complex [4] [5];
FF it subsequently recruits TFIIH to enter the transcription complex [14] [15] [16];
FF may be dispensable for the transcription of certain promoters [9];
FF stimulates the kinase activity of TFIIH to phosphorylate the C-terminal domain of the largest RNA polymerase II subunit [10];
FF also required for promoter clearance from linear, but not from negatively supercoiled templates [11];
FF nevertheless seems to facilitate promoter melting on negatively supercoiled DNA [12];
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IN T00456 Kr; fruit fly, Drosophila melanogaster.
IN T00818 TFIIB; human, Homo sapiens.
IN T02181 TFIIH-p90; human, Homo sapiens.
IN T02262 TFIIH; human, Homo sapiens.
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BS R00996.
BS R01018.
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DR TRANSPATH: MO000025195.
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RN [1]; RE0000062.
RX PUBMED: 3416354.
RA Horikoshi M., Hai T., Lin Y.-S., Green M. R., Roeder R. G.
RT Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex
RL Cell 54:1033-1042 (1988).
RN [2]; RE0005676.
RX PUBMED: 7753175.
RA Sauer F., Fondell J. D., Ohkuma Y., Roeder R. G., Jaeckle H.
RT Control of transcription by Krueppel through interactions with TFIIB and TFIIEbeta
RL Nature 375:162-164 (1995).
RN [3]; RE0005716.
RX PUBMED: 2251258.
RA Ohkuma Y., Sumimoto H., Horikoshi M., Roeder R. G.
RT Factors involved in specific transcription by mammalian RNA polymerase II: purification and characterization of general transcription factor TFIIE
RL Proc. Natl. Acad. Sci. USA 87:9163-9167 (1990).
RN [4]; RE0005717.
RX PUBMED: 2026628.
RA Inostroza J., Flores O., Reinberg D.
RT Factors involved in specific transcription by mammalian RNA polymerase II. Purification and functional analysis of general transcription factor IIE
RL J. Biol. Chem. 266:9304-9308 (1991).
RN [5]; RE0005718.
RX PUBMED: 1956398.
RA Peterson M. G., Inostroza J., Maxon M. E., Flores O., Admon A., Reinberg D., Tjian R.
RT Structure and functional properties of human general transcription factor IIE
RL Nature 354:369-373 (1991).
RN [6]; RE0005721.
RX PUBMED: 3029109.
RA Reinberg D., Roeder R. G.
RT Factors involved in specific transcription by mammalian RNA polymerase II. Purification and functional analysis of initiation factors IIB and IIE
RL J. Biol. Chem. 262:3310-3321 (1987).
RN [7]; RE0005722.
RX PUBMED: 2566609.
RA Flores O., Maldonado E., Reinberg D.
RT Factors involved in specific transcription by mammalian RNA polymerase II. Factors IIE and IIF independently interact with RNA polymerase II
RL J. Biol. Chem. 264:8913-8921 (1989).
RN [8]; RE0005723.
RX PUBMED: 3392044.
RA Flores O., Maldonado E., Burton Z., Greenblatt J., Reinberg D.
RT Factors involved in specific transcription by mamalian RNA polymerase II
RL J. Biol. Chem. 263:10812-10816 (1988).
RN [9]; RE0005725.
RX PUBMED: 1547507.
RA Parvin J. D., Timmers H. T. M., Sharp P. A.
RT Promoter specificity of basal transcription factors
RL Cell 68:1135-1144 (1992).
RN [10]; RE0005726.
RX PUBMED: 8166891.
RA Ohkuma Y., Roeder R. G.
RT Regulation of TFIIH ATPase and kinase activities by TFIIE during active initiation complex formation
RL Nature 368:160-163 (1994).
RN [11]; RE0005727.
RX PUBMED: 8156590.
RA Goodrich J. A., Tjian R.
RT Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II
RL Cell 77:145-156 (1994).
RN [12]; RE0005729.
RX PUBMED: 7882984.
RA Holstege F. C. P., Tantin D., Carey M., van der Vliet P. C., Timmers H. T. M.
RT The requirement for the basal transcription factor IIE is determined by the helical stability of promoter DNA
RL EMBO J. 14:810-819 (1995).
RN [13]; RE0005730.
RX PUBMED: 7559497.
RA Kang M. E., Dahmus M. E.
RT The photochemical cross-linking of recombinant C-terminal domain to proteins in a HeLa cell transcription extract that comigrate with transcription factor IIE and IIF
RL J. Biol. Chem. 270:23390-23397 (1995).
RN [14]; RE0005731.
RX PUBMED: 7651404.
RA Ohkuma Y., Hashimoto S., Wang K., Horikoshi M., Roeder R. G.
RT Analysis of the role of TFIIE in basal transcription and TFIIH-mediated carboxy-terminal domain phosphorylation through structure-function studies of TFIIE-alpha
RL Mol. Cell. Biol. 15:4856-4866 (1995).
RN [15]; RE0005732.
RX PUBMED: 8152490.
RA Drapkin R., Reardon J. T., Ansari A., Huang J.-C., Zawel L., Ahn K., Sancar A., Reinberg D.
RT Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
RL Nature 368:769-772 (1994).
RN [16]; RE0005733.
RX PUBMED: 7926747.
RA Maxon M. E., Goodrich J. A., Tjian R.
RT Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance
RL Genes Dev. 8:515-524 (1994).
RN [17]; RE0005734.
RX PUBMED: 7876263.
RA Park C. H., Mu D., Reardon J. T., Sancar A.
RT The general transcription-repair factor TFIIH is recruited to the excision repair complex by the XPA protein independent of the TFIIE transcription factor
RL J. Biol. Chem. 270:4896-4902 (1995).
RN [18]; RE0010601.
RX PUBMED: 7651391.
RA Tong X., Drapkin R., Yalamanchili R., Mosialos G., Kieff E.
RT The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE
RL Mol. Cell. Biol. 15:4735-4744 (1995).
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