AC T02182
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ID T02182
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DT 05.06.1997 (created); hiwi.
DT 07.11.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA TFIIH-p80
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SY EM9; ERCC2; excision repair cross complementing protein 2; MAG; malignancy-associated protein; XPD.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G008766 ERCC2; HGNC: ERCC2.
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HO RAD3 (yeast).
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SF associates with the CAK complex to a subcomplex of TFIIH [12] [28];
SF along with p62, it contributes to the TFIIH interaction with acidic trans-activation domains of upstream activators [10];
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FF TFIIH-p80 (XPD/ERCC2) is involved in DNA repair syndrome xeroderma pigmentosum (XP) group D [22];
FF helicase activity;
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IN T02184 cyclinH; human, Homo sapiens.
IN T02187 MAT1; human, Homo sapiens.
IN T02186 MO15; human, Homo sapiens.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T02260 TFIIH-CAK; human, Homo sapiens.
IN T02181 TFIIH-p90; human, Homo sapiens.
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DR TRANSPATH: MO000037601.
DR PATHODB: MT010772.
DR PATHODB: MT010773.
DR PATHODB: MT010774.
DR PATHODB: MT010775.
DR PATHODB: MT010776.
DR PATHODB: MT010777.
DR PATHODB: MT010778.
DR PATHODB: MT010779.
DR PATHODB: MT010780.
DR PATHODB: MT010781.
DR PATHODB: MT010782.
DR PATHODB: MT010783.
DR PATHODB: MT010784.
DR PATHODB: MT010789.
DR PATHODB: MT010790.
DR PATHODB: MT010791.
DR PATHODB: MT010792.
DR PATHODB: MT010793.
DR PATHODB: MT010794.
DR PATHODB: MT010795.
DR PATHODB: MT010796.
DR PATHODB: MT010798.
DR PATHODB: MT010799.
DR PATHODB: MT010801.
DR PATHODB: MT010802.
DR PATHODB: MT010803.
DR PATHODB: MT010804.
DR PATHODB: MT010805.
DR PATHODB: MT010809.
DR PATHODB: MT010813.
DR UniProtKB: P18074;
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RN [1]; RE0005726.
RX PUBMED: 8166891.
RA Ohkuma Y., Roeder R. G.
RT Regulation of TFIIH ATPase and kinase activities by TFIIE during active initiation complex formation
RL Nature 368:160-163 (1994).
RN [2]; RE0005731.
RX PUBMED: 7651404.
RA Ohkuma Y., Hashimoto S., Wang K., Horikoshi M., Roeder R. G.
RT Analysis of the role of TFIIE in basal transcription and TFIIH-mediated carboxy-terminal domain phosphorylation through structure-function studies of TFIIE-alpha
RL Mol. Cell. Biol. 15:4856-4866 (1995).
RN [3]; RE0005732.
RX PUBMED: 8152490.
RA Drapkin R., Reardon J. T., Ansari A., Huang J.-C., Zawel L., Ahn K., Sancar A., Reinberg D.
RT Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
RL Nature 368:769-772 (1994).
RN [4]; RE0005733.
RX PUBMED: 7926747.
RA Maxon M. E., Goodrich J. A., Tjian R.
RT Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance
RL Genes Dev. 8:515-524 (1994).
RN [5]; RE0005763.
RX PUBMED: 8157004.
RA van Vuuren A. J., Vermeulen W., Ma L., Weeda G., Appeldoorn E., Jaspers N. G. J., van der Eb A. J., Bootsma D., Hoeijmakers J. H. J., Humbert S., Schaeffer L., Egly J.-M.
RT Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH)
RL EMBO J. 13:1645-1653 (1994).
RN [6]; RE0005764.
RX PUBMED: 7664335.
RA Henning K. A., Li L., Iyer N., McDaniel L. D., Reagan M. S., Legerski R., Schultz R. A., Stefanini M., Lehmann A. R., Mayne L. V., Friedberg E. C.
RT The Cockayne Syndrome Group A Gene Encodes a WD Repeat Protein That Interacts with CSB Protein and a Subunit of RNA Polymerase II TFIIH
RL Cell 82:555-564 (1995).
RN [7]; RE0005765.
RX PUBMED: 7885450.
RA Serizawa H., Maekelae T. P., Conaway J. W., Conaway R. C., Weinberg R. A., Young R. A.
RT Association of Cdk-activating kinase subunits with transcription factor TFIIH
RL Nature 374:280-282 (1995).
RN [8]; RE0005766.
RX PUBMED: 7533895.
RA Shiekhattar R., Mermelstein F., Fisher R. P., Drapkin R., Dynlacht B., Wessling H. C., Morgan D. O., Reinberg D.
RT Cdk-activating kinase complex is a component of human transcription factor TFIIH
RL Nature 374:283-287 (1995).
RN [9]; RE0005767.
RX PUBMED: 7566158.
RA Akoulitchev S., Maekelae T. P., Weinberg R. A., Reinberg D.
RT Requirement for TFIIH kinase activity in transcription by RNA polymerase II
RL Nature 377:557-560 (1995).
RN [10]; RE0005768.
RX PUBMED: 7724549.
RA Tong X., Drapkin R., Reinberg D., Kieff E.
RT The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2
RL Proc. Natl. Acad. Sci. USA 92:3259-3263 (1995).
RN [11]; RE0005769.
RX PUBMED: 7761469.
RA Makela T. P., Parvin J. D., Kim J., Huber L. J., Sharp P. A., Weinberg R. A.
RT A kinase-deficient transcription factor TFIIH is functional in basal an activated transcription
RL Proc. Natl. Acad. Sci. USA 92:5174-5178 (1995).
RN [12]; RE0005770.
RX PUBMED: 8692841.
RA Reardon J. T., Ge H., Gibbs E., Sancar A., Hurwitz J., Pan Z.-Q.
RT Isolation and characterization of two human transcription factor IIH(TFIIH)-related complexes: ERCC2/CAK and TFIIH*
RL Proc. Natl. Acad. Sci. USA 93:6482-6487 (1996).
RN [13]; RE0005771.
RX PUBMED: 2552440.
RA Conaway R. C., Conaway J. W.
RT An RNA polymerase II transcription factor has an associated DNA-dependent ATPase (dATPase) activity strongly stimulated by the TATA region of promoters
RL Proc. Natl. Acad. Sci. USA 86:7356-7360 (1989).
RN [14]; RE0005772.
RX PUBMED: 1939143.
RA Gerard M., Fischer L., Moncollin V., Chipoulet J.-M., Chambon P., Egly J.-M.
RT Purification and interaction properties of the human RNA polymerase B(II) general transcription factor BTF2
RL J. Biol. Chem. 266:20940-20945 (1991).
RN [15]; RE0005773.
RX PUBMED: 1733973.
RA Flores O., Lu H., Reinberg D.
RT Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH
RL J. Biol. Chem. 267:2786-2793 (1992).
RN [16]; RE0005774.
RX PUBMED: 1495560.
RA Lu H., Zawel L., Fisher L., Egly J.-M., Reinberg D.
RT Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
RL Nature 358:641-645 (1992).
RN [17]; RE0005775.
RX PUBMED: 1529339.
RA Fischer L., Gerard M., Chalut C., Lutz Y., Humbert S., Kanno M., Chambon P., Egly J.-M.
RT Cloning of the 62-kilodalton component of basic transcription factor BTF2
RL Science 257:1392-1395 (1992).
RN [18]; RE0005776.
RX PUBMED: 8465201.
RA Schaeffer L., Roy R., Humbert S., Moncollin V., Vermeulen W., Hoeijmakers J. H. J., Chambon P., Egly J.-M.
RT DNA repair helicase: A component of BTF2 (TFIIH) basic transcription factor260
RL Science 260:58-63 (1993).
RN [19]; RE0005777.
RX PUBMED: 8001135.
RA Roy R., Adamczewski J. P., Seroz T., Vermeulen W., Tassan J.-P., Schaeffer L., Nigg E. A., Hoeijmakers J. H. J., Egly J.-M.
RT The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor
RL Cell 79:1093-1101 (1994).
RN [20]; RE0005778.
RX PUBMED: 8007973.
RA Stelzer G., Goppelt A., Lottspeich F., Meisterernst M.
RT Repression of basal transcription by HMG2 is counteracted by TFIIH-associated factors in an ATP-dependent process
RL Mol. Cell. Biol. 14:4712-4721 (1994).
RN [21]; RE0005779.
RX PUBMED: 8194529.
RA Humbert S., van Vuuren H., Lutz Y., Hoeijmakers J. H. J., Egly J.-M., Moncollin V.
RT p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair
RL EMBO J. 13:2393-2398 (1994).
RN [22]; RE0005780.
RX PUBMED: 8194528.
RA Schaeffer L., Moncollin V., Roy R., Staub A., Mezzina M., Sarasin A., Weeda G., Hoeijmakers J. H. J., Egly J.-M.
RT The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor
RL EMBO J. 13:2388-2392 (1994).
RN [23]; RE0005781.
RX PUBMED: 7935417.
RA Xiao H., Pearson A., Coulombe B., Truant R., Zhang S., Regier J. L., Triezenberg S. J., Reinberg D., Flores O., Ingles C. J., Greenblatt J.
RT Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53
RL Mol. Cell. Biol. 14:7013-7024 (1994).
RN [24]; RE0005782.
RX PUBMED: 7937133.
RA Ma L., Siemssen E. D., Noteborn H. M., van der Eb A. J.
RT The xeroderma pigmentosum group B protein ERCC3 produced in the baculovirus system exhibits DNA helicase activity
RL Nucleic Acids Res. 22:4095-4102 (1994).
RN [25]; RE0005783.
RX PUBMED: 7592583.
RA Yankulov K., Yamashita K., Roy R., Egly J. M., Bentley D. L.
RT The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase
RL J. Biol. Chem. 270:23922-23925 (1995).
RN [26]; RE0005784.
RX PUBMED: 8612591.
RA Holstege F. C. P., van der Vliet P. C., Timmers H. T. M.
RT Opening of an RNA polymerase II promoter occurs in two distinct steps and requires the basal transcription factors IIE and IIH
RL EMBO J. 15:1666-1677 (1996).
RN [27]; RE0005785.
RX PUBMED: 8668144.
RA Yankulov K. Y., Pandes M., McCracken S., Bouchard D., Bentley D. L.
RT TFIIH functions in regulating transcriptional elongation by RNA polymerase II in Xenopus oocytes
RL Mol. Cell. Biol. 16:3291-3299 (1996).
RN [28]; RE0005786.
RX PUBMED: 8617234.
RA Adamczewski J. P., Rossignol M., Tassan J.-P., Nigg E. A., Moncollin V., Egly J.-M.
RT MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH
RL EMBO J. 15:1877-1884 (1996).
RN [29]; RE0047702.
RX PUBMED: 12419226.
RA Bradsher J., Auriol J., Proietti De Santis L., Iben S., Vonesch J. L., Grummt I., Egly J. M.
RT CSB is a component of RNA pol I transcription.
RL Mol. Cell 10:819-829 (2002).
RN [30]; RE0071142.
RX PUBMED: 16884686.
RA Takeuchi T., Inoue S., Yokosawa H.
RT Identification and Herc5-mediated ISGylation of novel target proteins.
RL Biochem. Biophys. Res. Commun. 348:473-477 (2006).
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