AC T02260
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ID T02260
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DT 07.11.1997 (created); ewi.
DT 14.12.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA TFIIH-CAK
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SY CAK; cdk-activating kinase; cyclin-dependent kinase-activating kinase; MO15(h):cyclin H(h):MAT1(h); TFIIH-CAK.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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SF subcomplex of TFIIH, comprising MO15/Cdk7 T02186, cyclin H T02184, and MAT1/p36 T02187 [3] [7];
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FF MO15 seems to autophosphorylate and phosphorylate cyclin H and MAT in the trimeric complex CAK [10];
FF protein kinase, phosphorylating the CTD (C-terminal domain) of the largest subunit of RNA pol II in cell cycle-dependent manner [1] [2] [4] [5];
FF this phosphorylation is essential for transcription elongation, but not for initiation [6];
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IN T00671 p53; human, Homo sapiens.
IN T02182 TFIIH-p80; human, Homo sapiens.
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DR TRANSPATH: MO000021902.
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RN [1]; RE0005765.
RX PUBMED: 7885450.
RA Serizawa H., Maekelae T. P., Conaway J. W., Conaway R. C., Weinberg R. A., Young R. A.
RT Association of Cdk-activating kinase subunits with transcription factor TFIIH
RL Nature 374:280-282 (1995).
RN [2]; RE0005766.
RX PUBMED: 7533895.
RA Shiekhattar R., Mermelstein F., Fisher R. P., Drapkin R., Dynlacht B., Wessling H. C., Morgan D. O., Reinberg D.
RT Cdk-activating kinase complex is a component of human transcription factor TFIIH
RL Nature 374:283-287 (1995).
RN [3]; RE0005770.
RX PUBMED: 8692841.
RA Reardon J. T., Ge H., Gibbs E., Sancar A., Hurwitz J., Pan Z.-Q.
RT Isolation and characterization of two human transcription factor IIH(TFIIH)-related complexes: ERCC2/CAK and TFIIH*
RL Proc. Natl. Acad. Sci. USA 93:6482-6487 (1996).
RN [4]; RE0005774.
RX PUBMED: 1495560.
RA Lu H., Zawel L., Fisher L., Egly J.-M., Reinberg D.
RT Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
RL Nature 358:641-645 (1992).
RN [5]; RE0005777.
RX PUBMED: 8001135.
RA Roy R., Adamczewski J. P., Seroz T., Vermeulen W., Tassan J.-P., Schaeffer L., Nigg E. A., Hoeijmakers J. H. J., Egly J.-M.
RT The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor
RL Cell 79:1093-1101 (1994).
RN [6]; RE0005784.
RX PUBMED: 8612591.
RA Holstege F. C. P., van der Vliet P. C., Timmers H. T. M.
RT Opening of an RNA polymerase II promoter occurs in two distinct steps and requires the basal transcription factors IIE and IIH
RL EMBO J. 15:1666-1677 (1996).
RN [7]; RE0005786.
RX PUBMED: 8617234.
RA Adamczewski J. P., Rossignol M., Tassan J.-P., Nigg E. A., Moncollin V., Egly J.-M.
RT MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH
RL EMBO J. 15:1877-1884 (1996).
RN [8]; RE0022069.
RX PUBMED: 9878675.
RA Hengstschlaeger M., Braun K., Soucek T., Miloloza A., Hengstschlaeger-Ottnand E.
RT Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle
RL Mutat. Res. 436:1-9 (1999).
RN [9]; RE0054706.
RX PUBMED: 10428966.
RA Vandel L., Kouzarides T.
RT Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase.
RL EMBO J. 18:4280-4291 (1999).
RN [10]; RE0020953.
RX PUBMED: 9315650.
RA Lu H., Fisher R. P., Bailey P., Levine A. J.
RT The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro
RL Mol. Cell. Biol. 17:5923-5934 (1997).
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