AC T02184
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ID T02184
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DT 05.06.1997 (created); hiwi.
DT 07.04.2009 (updated); jag.
CO Copyright (C), QIAGEN.
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FA cyclinH
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SY cyclin H; TFIIH-cyclin H.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003989 CCNH; HGNC: CCNH.
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HO CCL1 (yeast).
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SF part of the CAK (cyclin-dependent kinase-activating kinase) complex of holo-TFIIH [1] [2];
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FF controls the kinase activity of the MO15/Cdk7 moiety of the CAK subcomplex of TFIIH;
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IN T06040 CtBP2; human, Homo sapiens.
IN T02187 MAT1; human, Homo sapiens.
IN T02186 MO15; human, Homo sapiens.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T00641 POU2F1-isoform1; human, Homo sapiens.
IN T01330 RAR-gamma1; human, Homo sapiens.
IN T02185 TFIIH-p44; human, Homo sapiens.
IN T02182 TFIIH-p80; human, Homo sapiens.
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DR TRANSPATH: MO000023479.
DR UniProtKB: P51946;
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RN [1]; RE0005770.
RX PUBMED: 8692841.
RA Reardon J. T., Ge H., Gibbs E., Sancar A., Hurwitz J., Pan Z.-Q.
RT Isolation and characterization of two human transcription factor IIH(TFIIH)-related complexes: ERCC2/CAK and TFIIH*
RL Proc. Natl. Acad. Sci. USA 93:6482-6487 (1996).
RN [2]; RE0005786.
RX PUBMED: 8617234.
RA Adamczewski J. P., Rossignol M., Tassan J.-P., Nigg E. A., Moncollin V., Egly J.-M.
RT MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH
RL EMBO J. 15:1877-1884 (1996).
RN [3]; RE0035947.
RX PUBMED: 12527756.
RA Talukder A. H., Mishra S. K., Mandal M., Balasenthil S., Mehta S., Sahin A. A., Barnes C. J., Kumar R.
RT MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions.
RL J. Biol. Chem. 278:11676-11685 (2003).
RN [4]; RE0023310.
RX PUBMED: 10748061.
RA Bastien J., Adam-Stitah S., Riedl T., Egly J. M., Chambon P., Rochette-Egly C.
RT TFIIH interacts with the retinoic acid receptor gamma and phosphorylates its AF-1-activating domain through cdk7.
RL J. Biol. Chem. 275:21896-21904 (2000).
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