AC T31844
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ID T31844
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DT 01.03.1999 (created); ili.
DT 06.03.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA topoisomerase-II-alpha
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SY SC1; TOP2A; Topo II alpha.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002329 TOP2A; HGNC: TOP2A.
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SF map to 17q21-q22;
SF different from topoisomerase II beta [3];
SF Lys-rich DNA binding domain [2];
SF homodimer [2];
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CP K562 erythroleukemia cells [1]; HeLa [4] [1] [4].
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FF controls chromosome structure by direct protein binding [2];
FF structural role is redundant to topoisomerase I and H1 [2];
FF strand-passing catalytic activity [2];
FF requires ATP for catalytic activity [2];
FF catalytic activity is not required for chromosome assembly [2];
FF not affected by stabilization procedures during matrix preparation [1];
FF not present in the nucleoli [1];
FF important for kinetochore assembly, separation of sister chromatids and chromosome condensation [3] [4];
FF almost completely degraded in apoptotic hematopoietic cells [5];
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IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T15204 brca1; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T08562 CREB1; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T21852 HDAC1; Mammalia.
IN T02186 MO15; human, Homo sapiens.
IN T25008 pRb; Mammalia.
IN T09133 YY1; Mammalia.
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BS R29117.
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DR TRANSPATH: MO000056100.
DR SMARTDB: SB000038.
DR UniProtKB: P11388; TP2A_HUMAN.
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RN [1]; RE0013347.
RX PUBMED: 9215557.
RA Neri L. M., Fackelmayer F. O., Zweyer M., Kohwi-Shigematsu T., Martelli A. M.
RT Subnuclear localization of S/MAR-binding proteins is differently affected by in vitro stabilization with heat or Cu2+
RL Chromosoma 106:81-93 (1997).
RN [2]; RE0013351.
RX PUBMED: 9548561.
RA Bojanowski K., Maniotis A. J., Plisov S., Larsen A. K., Ingber D. E.
RT DNA topoisomerase II can drive changes in higher order chromosome architecture without enzymatically modifying DNA
RL J. Cell. Biochem. 69:127-142 (1998).
RN [3]; RE0013397.
RX PUBMED: 9046238.
RA Warburton P. E., Earnshaw W. C.
RT Untangling the role of DNA topoisomerase II in mitotic chromosome structure and function
RL BioEssays 19:97-99 (1997).
RN [4]; RE0013398.
RX PUBMED: 3016287.
RA Gasser S. M., Laroch T., Falquet J., Boy de la Tour E., Laemmli U. K.
RT Metaphase chromosome structure. Involvement of topoisomerase II
RL J. Mol. Biol. 188:613-629 (1986).
RN [5]; RE0017467.
RX PUBMED: 10025665.
RA Martelli A. M., Bortul R., Fackelmayer F. O., Tazzari P. L., Bareggi R., Narducci P., Zweyer M.
RT Biochemical and morphological characterization of the nuclear matrix from apoptotic HL-60 cells
RL J. Cell. Biochem. 72:35-46 (1999).
RN [6]; RE0047839.
RX PUBMED: 11136718.
RA Johnson C. A., Padget K., Austin C. A., Turner B. M.
RT Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis.
RL J. Biol. Chem. 276:4539-4542 (2001).
RN [7]; RE0047941.
RX PUBMED: 8387155.
RA Kroll D. J., Sullivan D. M., Gutierrez-Hartmann A., Hoeffler J. P.
RT Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine-3',5'-monophosphate response element-binding protein and related transcription factors.
RL Mol. Endocrinol. 7:305-318 (1993).
RN [8]; RE0047983.
RX PUBMED: 12466558.
RA Morrison C., Henzing A. J., Jensen O. N., Osheroff N., Dodson H., Kandels-Lewis S. E., Adams R. R., Earnshaw W. C.
RT Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate.
RL Nucleic Acids Res. 30:5318-5327 (2002).
RN [9]; RE0048463.
RX PUBMED: 10862613.
RA Mao Y., Desai S. D., Liu L. F.
RT SUMO-1 conjugation to human DNA topoisomerase II isozymes.
RL J. Biol. Chem. 275:26066-26073 (2000).
RN [10]; RE0051076.
RX PUBMED: 16091739.
RA Xiao H., Goodrich D. W.
RT The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes.
RL Oncogene 24:8105-8113 (2005).
RN [11]; RE0051121.
RX PUBMED: 15965487.
RA Lou Z., Minter-Dykhouse K., Chen J.
RT BRCA1 participates in DNA decatenation.
RL Nat. Struct. Mol. Biol. 12:589-593 (2005).
RN [12]; RE0064053.
RX PUBMED: 17636313.
RA Stros M., Bacikova A., Polanska E., Stokrova J., Strauss F.
RT HMGB1 interacts with human topoisomerase IIalpha and stimulates its catalytic activity.
RL Nucleic Acids Res. 35:5001-5013 (2007).
RN [13]; RE0065316.
RX PUBMED: 19098900.
RA Luo K., Yuan J., Chen J., Lou Z.
RT Topoisomerase IIalpha controls the decatenation checkpoint.
RL Nat. Cell Biol. 11:204-210 (2009).
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