![TRANSFAC-Logo](/transfac_factor/images/logo_genexplain.png)
AC T21852
XX
ID T21852
XX
DT 10.03.2005 (created); nvo.
DT 02.09.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA HDAC1
XX
SY HD1; HDAC-1; histone deacetylase 1; RPD3L1.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T09248 AML2-isoform1; human, Homo sapiens.
IN T09552 AML3; Mammalia.
IN T08487 AR-isoform1; human, Homo sapiens.
IN T15601 AR; Mammalia.
IN T08910 Bcl-3; human, Homo sapiens.
IN T16043 BCL-6; Mammalia.
IN T14513 beta-catenin; Mammalia.
IN T09948 BF-1; mouse, Mus musculus.
IN T17923 Blimp-1; Mammalia.
IN T15079 BTEB2-isoform1; human, Homo sapiens.
IN T10873 c-Ets-1; Mammalia.
IN T08519 C2TA-isoform1; human, Homo sapiens.
IN T09429 COUP-TF2; mouse, Mus musculus.
IN T09050 DEC1; rat, Rattus norvegicus.
IN T22036 DEC1; mouse, Mus musculus.
IN T27196 DNA (cytosine-5)-methyltransferase 3A-isoform1; mouse, Mus musculus.
IN T27185 Dnmt1-L; mouse, Mus musculus.
IN T27861 DNMT3L-isoform1; human, Homo sapiens.
IN T08294 EKLF; mouse, Mus musculus.
IN T23093 EKLF; Mammalia.
IN T08445 Elk1-isoform1; human, Homo sapiens.
IN T19299 Epicardin; mouse, Mus musculus.
IN T09637 ER-alpha; Mammalia.
IN T10210 Evi-1; human, Homo sapiens.
IN T30499 gli3; Mammalia.
IN T24827 Gsc; mouse, Mus musculus.
IN T21852 HDAC1; Mammalia.
IN T23418 HDAC1; mouse, Mus musculus.
IN T25625 hdac2; human, Homo sapiens.
IN T19634 HES 7; Mammalia.
IN T09934 Hey2; human, Homo sapiens.
IN T09040 HNF-1beta; human, Homo sapiens.
IN T08767 IkappaB-alpha; human, Homo sapiens.
IN T15475 Ikaros-1; Mammalia.
IN T06375 ING1b; human, Homo sapiens.
IN T25923 ING1c; human, Homo sapiens.
IN T34788 IRF-9; Mammalia.
IN T09551 LEF-1; Mammalia.
IN T08303 LRF-isoform2; mouse, Mus musculus.
IN T10759 MTA-1; human, Homo sapiens.
IN T10027 MyoD; Mammalia.
IN T08641 NCOR1-isoform1; mouse, Mus musculus.
IN T10399 NF-kappaB1-p50; Mammalia.
IN T15502 NKX2B; Mammalia.
IN T14258 Nkx3-2; chick, Gallus gallus.
IN T06148 p/CAF; human, Homo sapiens.
IN T01608 p130; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T00671 p53; human, Homo sapiens.
IN T14054 PARP; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
IN T09271 PEA3; zebra fish, Brachydanio rerio.
IN T02336 PLZF; human, Homo sapiens.
IN T14288 PLZF; Mammalia.
IN T19187 PML-4; human, Homo sapiens.
IN T09957 PPARbeta; Mammalia.
IN T25008 pRb; Mammalia.
IN T16056 RBPJK; Mammalia.
IN T10397 RelA-p65; Mammalia.
IN T10469 REST; Mammalia.
IN T15302 Sall1; Mammalia.
IN T00737 SAP-1a; human, Homo sapiens.
IN T10594 SHP; human, Homo sapiens.
IN T23084 SHP; Mammalia.
IN T14622 sin3a; human, Homo sapiens.
IN T04689 SMRT; human, Homo sapiens.
IN T23076 STAT1; Mammalia.
IN T16670 STAT2; Mammalia.
IN T01799 Tal-1; mouse, Mus musculus.
IN T11420 Tbx3; human, Homo sapiens.
IN T16578 TGIF; Mammalia.
IN T18812 TIP5; mouse, Mus musculus.
IN T31844 topoisomerase-II-alpha; human, Homo sapiens.
IN T09133 YY1; Mammalia.
IN T19572 ZNF76-isoform2; human, Homo sapiens.
XX
MX M07041 V$HDAC1_Q3.
XX
BS R34760.
BS R34764.
XX
DR TRANSPATH: MO000047241.
XX
RN [1]; RE0005939.
RX PUBMED: 9150137.
RA Nagy L., Kao H.-Y., Chakravarti D., Lin R. J., Hassig C. A., Ayer D. E., Schreiber S. L., Evans R. M.
RT Nuclear receptor repression mediated by a complex containing SMRT, mSin3a, and histone deacetylase
RL Cell 89:373-380 (1997).
RN [2]; RE0014872.
RX PUBMED: 9150135.
RA Zhang Y., Iratni R., Erdjument-Bromage H., Tempst P., Reinberg D.
RT Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex
RL Cell 89:357-364 (1997).
RN [3]; RE0015891.
RX PUBMED: 10753885.
RA Marzio G., Wagener C., Gutierrez M. I., Cartwright P., Helin K., Giacca M.
RT E2F family members are differentially regulated by reversible acetylation.
RL J. Biol. Chem. 275:10887-10892 (2000).
RN [4]; RE0022585.
RX PUBMED: 11238380.
RA Sif S., Saurin A. J., Imbalzano A. N., Kingston R. E.
RT Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.
RL Genes Dev. 15:603-618 (2001).
RN [5]; RE0023713.
RX PUBMED: 11238932.
RA Yao J., Lai E., Stifani S.
RT The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.
RL Mol. Cell. Biol. 21:1962-1972 (2001).
RN [6]; RE0025355.
RX PUBMED: 12435627.
RA Dai P., Shinagawa T., Nomura T., Harada J., Kaul S. C., Wadhwa R., Khan M. M., Akimaru H., Sasaki H., Colmenares C., Ishii S.
RT Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3.
RL Genes Dev. 16:2843-2848 (2002).
RN [7]; RE0025559.
RX PUBMED: 10846170.
RA Cai R. L., Yan-Neale Y., Cueto M. A., Xu H., Cohen D.
RT HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.
RL J. Biol. Chem. 275:27909-16 (2000).
RN [8]; RE0026627.
RX PUBMED: 10933397.
RA Youn H. D., Liu J. O.
RT Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2.
RL Immunity 13:85-94 (2000).
RN [9]; RE0027396.
RX PUBMED: 10734134.
RA Nicolas E., Morales V., Magnaghi-Jaulin L., Harel-Bellan A., Richard-Foy H., Trouche D.
RT RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein.
RL J. Biol. Chem. 275:9797-804 (2000).
RN [10]; RE0027552.
RX PUBMED: 10640275.
RA Huang E. Y., Zhang J., Miska E. A., Guenther M. G., Kouzarides T., Lazar M. A.
RT Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.
RL Genes Dev. 14:45-54 (2000).
RN [11]; RE0027768.
RX PUBMED: 10570134.
RA Naruse Y., Aoki T., Kojima T., Mori N.
RT Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes.
RL Proc. Natl. Acad. Sci. USA 96:13691-6 (1999).
RN [12]; RE0027905.
RX PUBMED: 11118440.
RA Skowyra D., Zeremski M., Neznanov N., Li M., Choi Y., Uesugi M., Hauser C. A., Gu W., Gudkov A. V., Qin J.
RT Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.
RL J. Biol. Chem. 276:8734-9 (2001).
RN [13]; RE0028253.
RX PUBMED: 11319226.
RA D'Souza S. J., Pajak A., Balazsi K., Dagnino L.
RT Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation.
RL J. Biol. Chem. 276:23531-8 (2001).
RN [14]; RE0028350.
RX PUBMED: 11302704.
RA Taplick J., Kurtev V., Kroboth K., Posch M., Lechner T., Seiser C.
RT Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1.
RL J. Mol. Biol. 308:27-38 (2001).
RN [15]; RE0029293.
RX PUBMED: 11804585.
RA Fischle W., Dequiedt F., Hendzel M. J., Guenther M. G., Lazar M. A., Voelter W., Verdin E.
RT Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
RL Mol. Cell 9:45-57 (2002).
RN [16]; RE0029363.
RX PUBMED: 11568182.
RA Chakraborty S., Senyuk V., Sitailo S., Chi Y., Nucifora G.
RT Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles.
RL J. Biol. Chem. 276:44936-43 (2001).
RN [17]; RE0029628.
RX PUBMED: 11994312.
RA Gaughan L., Logan I. R., Cook S., Neal D. E., Robson C. N.
RT Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.
RL J. Biol. Chem. 277:25904-13 (2002).
RN [18]; RE0029969.
RX PUBMED: 12724404.
RA Fleischer T. C., Yun U. J., Ayer D. E.
RT Identification and Characterization of Three New Components of the mSin3A Corepressor Complex.
RL Mol. Cell. Biol. 23:3456-67 (2003).
RN [19]; RE0031368.
RX PUBMED: 12789260.
RA La Sala D., Macaluso M., Trimarchi C., Giordano A., Cinti C.
RT Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes.
RL Oncogene 22:3518-3529 (2003).
RN [20]; RE0031419.
RX PUBMED: 12972430.
RA Viatour P., Legrand-Poels S., van Lint C., Warnier M., Merville M. P., Gielen J., Piette J., Bours V., Chariot A.
RT Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3.
RL J. Biol. Chem. 278:46541-8 (2003).
RN [21]; RE0031711.
RX PUBMED: 11684023.
RA Puri P. L., Iezzi S., Stiegler P., Chen T. T., Schiltz R. L., Muscat G. E., Giordano A., Kedes L., Wang J. Y., Sartorelli V.
RT Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis.
RL Mol. Cell 8:885-97 (2001).
RN [22]; RE0032276.
RX PUBMED: 14612411.
RA Kim D. W., Lassar A. B.
RT Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2.
RL Mol. Cell. Biol. 23:8704-17 (2003).
RN [23]; RE0032479.
RX PUBMED: 11867749.
RA Shi Y., Hon M., Evans R. M.
RT The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.
RL Proc. Natl. Acad. Sci. USA 99:2613-8 (2002).
RN [24]; RE0032544.
RX PUBMED: 15000748.
RA Bae Y., Kemper J. K., Kemper B.
RT Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).
RL DNA Cell Biol. 23:81-91 (2004).
RN [25]; RE0033178.
RX PUBMED: 14645718.
RA Nusinzon I., Horvath C. M.
RT Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1.
RL Proc. Natl. Acad. Sci. USA 100:14742-7 (2003).
RN [26]; RE0035566.
RX PUBMED: 10688671.
RA Huang S., Brandt S. J.
RT mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor.
RL Mol. Cell. Biol. 20:2248-2259 (2000).
RN [27]; RE0036959.
RX PUBMED: 12659862.
RA Takenaga M., Hatano M., Takamori M., Yamashita Y., Okada S., Kuroda Y., Tokuhisa T.
RT Bcl6-dependent transcriptional repression by BAZF
RL Biochem. Biophys. Res. Commun. 303:600-8 (2003).
RN [28]; RE0037094.
RX PUBMED: 12198165.
RA Zhou Y., Santoro R., Grummt I.
RT The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription
RL EMBO J. 21:4632-40 (2002).
RN [29]; RE0037667.
RX PUBMED: 12202768.
RA Deplus R., Brenner C., Burgers W. A., Putmans P., Kouzarides T., de Launoit Y., Fuks F.
RT Dnmt3L is a transcriptional repressor that recruits histone deacetylase
RL Nucleic Acids Res. 30:3831-8 (2002).
RN [30]; RE0037668.
RX PUBMED: 15120635.
RA Geiman T. M., Sankpal U. T., Robertson A. K., Zhao Y., Zhao Y., Robertson K. D.
RT DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system
RL Biochem. Biophys. Res. Commun. 318:544-55 (2004).
RN [31]; RE0038023.
RX PUBMED: 10888618.
RA Coull J. J., Romerio F., Sun J. M., Volker J. L., Galvin K. M., Davie J. R., Shi Y., Hansen U., Margolis D. M.
RT The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1
RL J. Virol. 74:6790-9 (2000).
RN [32]; RE0038035.
RX PUBMED: 12393887.
RA Wen Y. D., Cress W. D., Roy A. L., Seto E.
RT Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I
RL J. Biol. Chem. 278:1841-7 (2003).
RN [33]; RE0038037.
RX PUBMED: 11739383.
RA Fischer D. D., Cai R., Bhatia U., Asselbergs F. A., Song C., Terry R., Trogani N., Widmer R., Atadja P., Cohen D.
RT Isolation and Characterization of a Novel Class II Histone Deacetylase, HDAC10
RL J. Biol. Chem. 277:6656-66 (2002).
RN [34]; RE0038072.
RX PUBMED: 11350943.
RA Fuks F., Burgers W. A., Godin N., Kasai M., Kouzarides T.
RT Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
RL EMBO J. 20:2536-44 (2001).
RN [35]; RE0038083.
RX PUBMED: 11466315.
RA Fischle W., Dequiedt F., Fillion M., Hendzel M. J., Voelter W., Verdin E.
RT Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo
RL J. Biol. Chem. 276:35826-35 (2001).
RN [36]; RE0038190.
RX PUBMED: 11909966.
RA Alland L., David G., Shen-Li H., Potes J., Muhle R., Lee H. C., Hou H. Jr, Chen K., DePinho R. A.
RT Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex
RL Mol. Cell. Biol. 22:2743-50 (2002).
RN [37]; RE0038632.
RX PUBMED: 11585818.
RA Satou A., Taira T., Iguchi-Ariga S. M., Ariga H.
RT A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein
RL J. Biol. Chem. 276:46562-7 (2001).
RN [38]; RE0038677.
RX PUBMED: 15199155.
RA Cheng J., Wang D., Wang Z., Yeh E. T.
RT SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1
RL Mol. Cell. Biol. 24:6021-8 (2004).
RN [39]; RE0039095.
RX PUBMED: 11006275.
RA Wei L. N., Hu X., Chandra D., Seto E., Farooqui M.
RT Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing
RL J. Biol. Chem. 275:40782-7 (2000).
RN [40]; RE0039675.
RX PUBMED: 11940654.
RA He G., Margolis D. M.
RT Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat
RL Mol. Cell. Biol. 22:2965-73 (2002).
RN [41]; RE0040355.
RX PUBMED: 10958684.
RA Billin A. N., Thirlwell H., Ayer D. E.
RT Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator
RL Mol. Cell. Biol. 20:6882-90 (2000).
RN [42]; RE0040744.
RX PUBMED: 11171972.
RA You A., Tong J. K., Grozinger C. M., Schreiber S. L.
RT CoREST is an integral component of the CoREST- human histone deacetylase complex
RL Proc. Natl. Acad. Sci. USA 98:1454-8 (2001).
RN [43]; RE0041249.
RX PUBMED: 14981544.
RA Gross M., Yang R., Top I., Gasper C., Shuai K.
RT PIASy-mediated repression of the androgen receptor is independent of sumoylation
RL Oncogene 23:3059-66 (2004).
RN [44]; RE0041454.
RX PUBMED: 10704340.
RA Smirnov D. A., Hou S., Ricciardi R. P.
RT Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription
RL Virology 268:319-28 (2000).
RN [45]; RE0041859.
RX PUBMED: 11306568.
RA Liberati N. T., Moniwa M., Borton A. J., Davie J. R., Wang X. F.
RT An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*
RL J. Biol. Chem. 276:22595-603 (2001).
RN [46]; RE0041993.
RX PUBMED: 15123634.
RA Klampfer L., Huang J., Swaby L. A., Augenlicht L.
RT Requirement of histone deacetylase activity for signaling by STAT1
RL J. Biol. Chem. 279:30358-68 (2004).
RN [47]; RE0042557.
RX PUBMED: 15138260.
RA Jin Y. H., Jeon E. J., Li Q. L., Lee Y. H., Choi J. K., Kim W. J., Lee K. Y., Bae S. C.
RT Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
RL J. Biol. Chem. 279:29409-17 (2004).
RN [48]; RE0044538.
RX PUBMED: 15051733.
RA Chittka A., Arevalo J. C., Rodriguez-Guzman M., Perez P., Chao M. V., Sendtner M.
RT The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E
RL J. Cell Biol. 164:985-96 (2004).
RN [49]; RE0044839.
RX PUBMED: 14581478.
RA Meehan W. J., Samant R. S., Hopper J. E., Carrozza M. J., Shevde L. A., Workman J. L., Eckert K. A., Verderame M. F., Welch D. R.
RT Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription
RL J. Biol. Chem. 279:1562-9 (2004).
RN [50]; RE0044860.
RX PUBMED: 10581039.
RA van der Vlag J., Otte A. P.
RT Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
RL Nat. Genet. 23:474-8 (1999).
RN [51]; RE0045096.
RX PUBMED: 11836251.
RA Kiefer S. M., McDill B. W., Yang J., Rauchman M.
RT Murine Sall1 represses transcription by recruiting a histone deacetylase complex
RL J. Biol. Chem. 277:14869-76 (2002).
RN [52]; RE0046843.
RX PUBMED: 10655483.
RA Zhou X., Richon V. M., Rifkind R. A., Marks P. A.
RT Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5
RL Proc. Natl. Acad. Sci. USA 97:1056-61 (2000).
RN [53]; RE0047163.
RX PUBMED: 14612401.
RA Fu M., Rao M., Wang C., Sakamaki T., Wang J., Di Vizio D., Zhang X., Albanese C., Balk S., Chang C., Fan S., Rosen E., Palvimo J. J., Janne O. A., Muratoglu S., Avantaggiati M. L., Pestell R. G.
RT Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth
RL Mol. Cell. Biol. 23:8563-75 (2003).
RN [54]; RE0047306.
RX PUBMED: 10737769.
RA Sun H., Taneja R.
RT Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms
RL Proc. Natl. Acad. Sci. USA 97:4058-63 (2000).
RN [55]; RE0047542.
RX PUBMED: 9724731.
RA Ferreira R., Magnaghi-Jaulin L., Robin P., Harel-Bellan A., Trouche D.
RT The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.
RL Proc. Natl. Acad. Sci. USA 95:10493-10498 (1998).
RN [56]; RE0047547.
RX PUBMED: 11146623.
RA Mazumdar A., Wang R. A., Mishra S. K., Adam L., Bagheri-Yarmand R., Mandal M., Vadlamudi R. K., Kumar R.
RT Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor.
RL Nat. Cell Biol. 3:30-37 (2001).
RN [57]; RE0047553.
RX PUBMED: 11929879.
RA Milutinovic S., Zhuang Q., Szyf M.
RT Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification.
RL J. Biol. Chem. 277:20974-20978 (2002).
RN [58]; RE0047660.
RX PUBMED: 12727880.
RA Wiper-Bergeron N., Wu D., Pope L., Schild-Poulter C., Hache R. J.
RT Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex.
RL EMBO J. 22:2135-2145 (2003).
RN [59]; RE0047711.
RX PUBMED: 12426395.
RA Ito A., Kawaguchi Y., Lai C. H., Kovacs J. J., Higashimoto Y., Appella E., Yao T. P.
RT MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
RL EMBO J. 21:6236-6245 (2002).
RN [60]; RE0047757.
RX PUBMED: 12177302.
RA Aapola U., Liiv I., Peterson P.
RT Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity.
RL Nucleic Acids Res. 30:3602-3608 (2002).
RN [61]; RE0047781.
RX PUBMED: 12697811.
RA Zika E., Greer S. F., Zhu X. S., Ting J. P.
RT Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation.
RL Mol. Cell. Biol. 23:3091-3102 (2003).
RN [62]; RE0047796.
RX PUBMED: 15469820.
RA Viatour P., Dejardin E., Warnier M., Lair F., Claudio E., Bureau F., Marine J. C., Merville M. P., Maurer U., Green D., Piette J., Siebenlist U., Bours V., Chariot A.
RT GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.
RL Mol. Cell 16:35-45 (2004).
RN [63]; RE0047821.
RX PUBMED: 11287616.
RA Chen X., Bieker J. J.
RT Unanticipated repression function linked to erythroid Kruppel-like factor.
RL Mol. Cell. Biol. 21:3118-3125 (2001).
RN [64]; RE0047839.
RX PUBMED: 11136718.
RA Johnson C. A., Padget K., Austin C. A., Turner B. M.
RT Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis.
RL J. Biol. Chem. 276:4539-4542 (2001).
RN [65]; RE0047847.
RX PUBMED: 15337766.
RA Liu C. J., Prazak L., Fajardo M., Yu S., Tyagi N., Di Cesare P. E.
RT Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis.
RL J. Biol. Chem. 279:47081-47091 (2004).
RN [66]; RE0047858.
RX PUBMED: 12198164.
RA Vietor I., Vadivelu S. K., Wick N., Hoffman R., Cotten M., Seiser C., Fialka I., Wunderlich W., Haase A., Korinkova G., Brosch G., Huber L. A.
RT TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells.
RL EMBO J. 21:4621-4631 (2002).
RN [67]; RE0047878.
RX PUBMED: 12045192.
RA Anderson L. A., Perkins N. D.
RT The large subunit of replication factor C interacts with the histone deacetylase, HDAC1.
RL J. Biol. Chem. 277:29550-29554 (2002).
RN [68]; RE0047935.
RX PUBMED: 9765306.
RA Wong C. W., Privalsky M. L.
RT Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6.
RL J. Biol. Chem. 273:27695-27702 (1998).
RN [69]; RE0047937.
RX PUBMED: 11331609.
RA Shi Y., Downes M., Xie W., Kao H. Y., Ordentlich P., Tsai C. C., Hon M., Evans R. M.
RT Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.
RL Genes Dev. 15:1140-1151 (2001).
RN [70]; RE0048042.
RX PUBMED: 15542849.
RA Chen X., Bieker J. J.
RT Stage-specific repression by the EKLF transcriptional activator.
RL Mol. Cell. Biol. 24:10416-10424 (2004).
RN [71]; RE0048072.
RX PUBMED: 12529406.
RA Yamagoe S., Kanno T., Kanno Y., Sasaki S., Siegel R. M., Lenardo M. J., Humphrey G., Wang Y., Nakatani Y., Howard B. H., Ozato K.
RT Interaction of histone acetylases and deacetylases in vivo.
RL Mol. Cell. Biol. 23:1025-1033 (2003).
RN [72]; RE0048074.
RX PUBMED: 11283259.
RA Yang S. H., Vickers E., Brehm A., Kouzarides T., Sharrocks A. D.
RT Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.
RL Mol. Cell. Biol. 21:2802-2814 (2001).
RN [73]; RE0048075.
RX PUBMED: 12150998.
RA Yang X., Zhang F., Kudlow J. E.
RT Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression.
RL Cell 110:69-80 (2002).
RN [74]; RE0048147.
RX PUBMED: 11279209.
RA Dressel U., Bailey P. J., Wang S. C., Downes M., Evans R. M., Muscat G. E.
RT A dynamic role for HDAC7 in MEF2-mediated muscle differentiation.
RL J. Biol. Chem. 276:17007-17013 (2001).
RN [75]; RE0048154.
RX PUBMED: 10984530.
RA Downes M., Ordentlich P., Kao H. Y., Alvarez J. G., Evans R. M.
RT Identification of a nuclear domain with deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 97:10330-10335 (2000).
RN [76]; RE0048157.
RX PUBMED: 14559791.
RA Kim H., Lee J. E., Cho E. J., Liu J. O., Youn H. D.
RT Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex.
RL Cancer Res. 63:6135-6139 (2003).
RN [77]; RE0048453.
RX PUBMED: 12032081.
RA Kirsh O., Seeler J. S., Pichler A., Gast A., Muller S., Miska E., Mathieu M., Harel-Bellan A., Kouzarides T., Melchior F., Dejean A.
RT The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
RL EMBO J. 21:2682-2691 (2002).
RN [78]; RE0048484.
RX PUBMED: 10860984.
RA Wen Y. D., Perissi V., Staszewski L. M., Yang W. M., Krones A., Glass C. K., Rosenfeld M. G., Seto E.
RT The histone deacetylase-3 complex contains nuclear receptor corepressors.
RL Proc. Natl. Acad. Sci. USA 97:7202-7207 (2000).
RN [79]; RE0048530.
RX PUBMED: 11865059.
RA Melnick A., Carlile G., Ahmad K. F., Kiang C. L., Corcoran C., Bardwell V., Prive G. G., Licht J. D.
RT Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.
RL Mol. Cell. Biol. 22:1804-1818 (2002).
RN [80]; RE0048851.
RX PUBMED: 11486045.
RA Iso T., Sartorelli V., Poizat C., Iezzi S., Wu H. Y., Chung G., Kedes L., Hamamori Y.
RT HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.
RL Mol. Cell. Biol. 21:6080-6089 (2001).
RN [81]; RE0049039.
RX PUBMED: 16107876.
RA Wang C., Ivanov A., Chen L., Fredericks W. J., Seto E., Rauscher FJ 3. r. d., Chen J.
RT MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.
RL EMBO J. 24:3279-3290 (2005).
RN [82]; RE0049373.
RX PUBMED: 15919722.
RA Hong C. Y., Gong E. Y., Kim K., Suh J. H., Ko H. M., Lee H. J., Choi H. S., Lee K.
RT Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1.
RL Mol. Endocrinol. 19:2245-2257 (2005).
RN [83]; RE0049828.
RX PUBMED: 16204234.
RA Hassa P. O., Haenni S. S., Buerki C., Meier N. I., Lane W. S., Owen H., Gersbach M., Imhof R., Hottiger M. O.
RT Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.
RL J. Biol. Chem. 280:40450-40464 (2005).
RN [84]; RE0050020.
RX PUBMED: 16337145.
RA Zheng G., Yang Y. C.
RT Acetylation and alternative splicing regulate ZNF76-mediated transcription.
RL Biochem. Biophys. Res. Commun. 339:1069-1075 (2006).
RN [85]; RE0051082.
RX PUBMED: 17895379.
RA Sanyal S., Bavner A., Haroniti A., Nilsson L. M., Lundasen T., Rehnmark S., Witt M. R., Einarsson C., Talianidis I., Gustafsson J. A., Treuter E.
RT Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.
RL Proc. Natl. Acad. Sci. USA 104:15665-15670 (2007).
RN [86]; RE0052059.
RX PUBMED: 11931769.
RA Zhong H., May M. J., Jimi E., Ghosh S.
RT The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.
RL Mol. Cell 9:625-636 (2002).
RN [87]; RE0052196.
RX PUBMED: 12947414.
RA Caron C., Pivot-Pajot C., van Grunsven L. A., Col E., Lestrat C., Rousseaux S., Khochbin S.
RT Cdyl: a new transcriptional co-repressor.
RL EMBO Rep. 4:877-882 (2003).
RN [88]; RE0052243.
RX PUBMED: 10615135.
RA Fuks F., Burgers W. A., Brehm A., Hughes-Davies L., Kouzarides T.
RT DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
RL Nat. Genet. 24:88-91 (2000).
RN [89]; RE0052552.
RX PUBMED: 12124384.
RA Saito M., Ishikawa F.
RT The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.
RL J. Biol. Chem. 277:35434-35439 (2002).
RN [90]; RE0052561.
RX PUBMED: 11285237.
RA Mal A., Sturniolo M., Schiltz R. L., Ghosh M. K., Harter M. L.
RT A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program.
RL EMBO J. 20:1739-1753 (2001).
RN [91]; RE0052675.
RX PUBMED: 11259576.
RA Wu W. S., Vallian S., Seto E., Yang W. M., Edmondson D., Roth S., Chang K. S.
RT The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases.
RL Mol. Cell. Biol. 21:2259-2268 (2001).
RN [92]; RE0052707.
RX PUBMED: 15325272.
RA Iwase S., Januma A., Miyamoto K., Shono N., Honda A., Yanagisawa J., Baba T.
RT Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.
RL Biochem. Biophys. Res. Commun. 322:601-608 (2004).
RN [93]; RE0052737.
RX PUBMED: 11564889.
RA Ashburner B. P., Westerheide S. D., Baldwin AS J. r.
RT The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression.
RL Mol. Cell. Biol. 21:7065-7077 (2001).
RN [94]; RE0052991.
RX PUBMED: 15509593.
RA Barbacci E., Chalkiadaki A., Masdeu C., Haumaitre C., Lokmane L., Loirat C., Cloarec S., Talianidis I., Bellanne-Chantelot C., Cereghini S.
RT HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment.
RL Hum. Mol. Genet. 13:3139-3149 (2004).
RN [95]; RE0053192.
RX PUBMED: 12015313.
RA Koipally J., Georgopoulos K.
RT A molecular dissection of the repression circuitry of Ikaros.
RL J. Biol. Chem. 277:27697-27705 (2002).
RN [96]; RE0053243.
RX PUBMED: 12920132.
RA Yao Y. L., Yang W. M.
RT The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.
RL J. Biol. Chem. 278:42560-42568 (2003).
RN [97]; RE0053639.
RX PUBMED: 15465827.
RA Wessells J., Baer M., Young H. A., Claudio E., Brown K., Siebenlist U., Johnson P. F.
RT BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages.
RL J. Biol. Chem. 279:49995-50003 (2004).
RN [98]; RE0054633.
RX PUBMED: 18722353.
RA Han Y., Jin Y. H., Kim Y. J., Kang B. Y., Choi H. J., Kim D. W., Yeo C. Y., Lee K. Y.
RT Acetylation of Sirt2 by p300 attenuates its deacetylase activity.
RL Biochem. Biophys. Res. Commun. 375:576-580 (2008).
RN [99]; RE0055310.
RX PUBMED: 16914725.
RA Lee M. G., Wynder C., Bochar D. A., Hakimi M. A., Cooch N., Shiekhattar R.
RT Functional interplay between histone demethylase and deacetylase enzymes.
RL Mol. Cell. Biol. 26:6395-6402 (2006).
RN [100]; RE0055392.
RX PUBMED: 15550569.
RA Boulias K., Talianidis I.
RT Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression.
RL Nucleic Acids Res. 32:6096-6103 (2004).
RN [101]; RE0055633.
RX PUBMED: 16805913.
RA Brown M. A., Sims RJ 3. r. d., Gottlieb P. D., Tucker P. W.
RT Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex.
RL Mol. Cancer 5:26 (2006).
RN [102]; RE0059382.
RX PUBMED: 14506733.
RA Kawai H., Li H., Avraham S., Jiang S., Avraham H. K.
RT Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha.
RL Int. J. Cancer 107:353-358 (2003).
RN [103]; RE0062876.
RX PUBMED: 16728531.
RA Lee H. W., Suh J. H., Kim A. Y., Lee Y. S., Park S. Y., Kim J. B.
RT Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation.
RL Mol. Endocrinol. 20:2432-2443 (2006).
RN [104]; RE0064434.
RX PUBMED: 18193082.
RA Binda O., Nassif C., Branton P. E.
RT SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins.
RL Oncogene 27:3384-3392 (2008).
RN [105]; RE0064769.
RX PUBMED: 15668237.
RA Matsumura T., Suzuki T., Aizawa K., Munemasa Y., Muto S., Horikoshi M., Nagai R.
RT The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Kruppel-like factor 5 through direct interaction.
RL J. Biol. Chem. 280:12123-12129 (2005).
RN [106]; RE0065790.
RX PUBMED: 19182791.
RA Oh Y. M., Kwon Y. E., Kim J. M., Bae S. J., Lee B. K., Yoo S. J., Chung C. H., Deshaies R. J., Seol J. H.
RT Chfr is linked to tumour metastasis through the downregulation of HDAC1.
RL Nat. Cell Biol. 11:295-302 (2009).
RN [107]; RE0066261.
RX PUBMED: 18936100.
RA Gao X., Wen J., Zhang L., Li X., Ning Y., Meng A., Chen Y. G.
RT Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus.
RL J. Biol. Chem. 283:35679-35688 (2008).
RN [108]; RE0070019.
RX PUBMED: 19949111.
RA Liu Z., Mai A., Sun J.
RT Lysine acetylation regulates Bruton's tyrosine kinase in B cell activation.
RL J. Immunol. 184:244-254 (2010).
XX
//