AC T09248
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ID T09248
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DT 21.08.2006 (created); din.
DT 13.01.2015 (updated); spk.
CO Copyright (C), QIAGEN.
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FA AML2-isoform1
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SY Acute myeloid leukemia 2 protein; AML2; CBF-alpha 3; CBFA3; Core-binding factor, alpha 3 subunit; PEBP2alphaC1; Polyomavirus enhancer binding protein 2 alpha C subunit; Runt-related transcription factor 3; RUNX3.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003994 RUNX3; HGNC: RUNX3.
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CL C0029; runt; 6.4.1.0.3.1.
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SZ 415 AA; 44.4 kDa (cDNA) (calc.).
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SQ MRIPVDPSTSRRFTPPSPAFPCGGGGGKMGENSGALSAQAAVGPGGRARPEVRSMVDVLA
SQ DHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAE
SQ LRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREP
SQ RRHRQKLEDQTKPFPDRFGDLERLRMRVTPSTPSPRGSLSTTSHFSSQPQTPIQGTSELN
SQ PFSDPRQFDRSFPTLPTLTESRFPDPRMHYPGAMSAAFPYSATPSGTSISSLSVAGMPAT
SQ SRFHHTYLPPPYPGAPQNQSGPFQANPSPYHLYYGTSSGSYQFSMVAGSSSGGDRSPTRM
SQ LASCTSSAASVAAGNLMNPSLGGQSDGVEADGSHSNSPTALSTPGRMDEAVWRPY
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SC Swiss-Prot#Q13761-1
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FT 52 186 
PF00853; Runt domain.
FT 54 182 
PS51062; RUNT.
FT 272 308 
putative nuclear matrix targeting signal [2].
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IN T02938 FOXO3a; human, Homo sapiens.
IN T10677 FOXO3a; Mammalia.
IN T21852 HDAC1; Mammalia.
IN T01427 p300; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T23072 PEBP2beta; Mammalia.
IN T09538 Smad3; Mammalia.
IN T13998 Smad4; Mammalia.
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MX M01814 V$AML2_Q3.
MX M01854 V$AML2_Q3_01.
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DR TRANSPATH: MO000085374.
DR EMBL: Z35278;
DR UniProtKB: Q13761-1;
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RN [1]; RE0005954.
RX PUBMED: 7622058.
RA Bae S., Takahashi E., Zhang Y., Ogawa E., Shigesada K., Namba Y., Satake M., Ito Y.
RT Cloning, mapping and expression of PEBP2alphaC, a third gene encoding the mammalian Runt domain
RL Gene 159:245-248 (1995).
RN [2]; RE0006488.
RX PUBMED: 9192636.
RA Zeng C., van Wijnen A. J., Stein J. L., Meyers S., Sun W., Shopland L., Lawrence J. B., Penman S., Lian J.B., Stein G. S., Hiebert S. W.
RT Identification of a nuclear matrix targeting signal in leukemia and bone-related AML/CBF-alpha transcription factors
RL Proc. Natl. Acad. Sci. USA 94:6746-6751 (1997).
RN [3]; RE0042557.
RX PUBMED: 15138260.
RA Jin Y. H., Jeon E. J., Li Q. L., Lee Y. H., Choi J. K., Kim W. J., Lee K. Y., Bae S. C.
RT Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
RL J. Biol. Chem. 279:29409-17 (2004).
RN [4]; RE0048110.
RX PUBMED: 16135801.
RA Chi X. Z., Yang J. O., Lee K. Y., Ito K., Sakakura C., Li Q. L., Kim H. R., Cha E. J., Lee Y. H., Kaneda A., Ushijima T., Kim W. J., Ito Y., Bae S. C.
RT RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.
RL Mol. Cell. Biol. 25:8097-8107 (2005).
RN [5]; RE0048307.
RX PUBMED: 16373335.
RA Yamamura Y., Lee W. L., Inoue K., Ida H., Ito Y.
RT RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells.
RL J. Biol. Chem. 281:5267-5276 (2006).
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