AC T21984
XX
ID T21984
XX
DT 02.01.2006 (created); jma.
DT 16.05.2016 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA p300
XX
SY CBP/p300; E1A associated protein; E1A binding protein p300; E1A-associated protein p300; EP300; KAT3B; p300; p300-HAT; RP1-85F18.1; RSTS2; transcriptional co-activator p300.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004631 EP300; HGNC: EP300.
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CP tBHQ-treated HepG2/GFP-B [1].
XX
IN T05109 53BP1; human, Homo sapiens.
IN T01795 AhR; human, Homo sapiens.
IN T01067 AML1; human, Homo sapiens.
IN T14315 AML1; Mammalia.
IN T02245 AML1b; human, Homo sapiens.
IN T09248 AML2-isoform1; human, Homo sapiens.
IN T09552 AML3; Mammalia.
IN T08487 AR-isoform1; human, Homo sapiens.
IN T04877 ATF-5; human, Homo sapiens.
IN T28731 AUF1; human, Homo sapiens.
IN T02872 beta-catenin; human, Homo sapiens.
IN T04074 brca1; human, Homo sapiens.
IN T00123 c-Fos; human, Homo sapiens.
IN T09007 c-Myc; mouse, Mus musculus.
IN T09998 c-Myc; human, Homo sapiens.
IN T00581 C/EBPbeta; human, Homo sapiens.
IN T18378 CBP; human, Homo sapiens.
IN T04891 CLOCK; human, Homo sapiens.
IN T27255 cnot4; human, Homo sapiens.
IN T22817 CREB{p}; human, Homo sapiens.
IN T10784 CtBP1; Mammalia.
IN T15605 E2A; human, Homo sapiens.
IN T09637 ER-alpha; Mammalia.
IN T08100 EWS; human, Homo sapiens.
IN T04956 FKLF; human, Homo sapiens.
IN T01390 GABP-alpha; human, Homo sapiens.
IN T00306 GATA-1; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T01610 HIF-1alpha; human, Homo sapiens.
IN T00950 IkappaB-alpha; human, Homo sapiens.
IN T06375 ING1b; human, Homo sapiens.
IN T08297 Kaiso; human, Homo sapiens.
IN T11439 KR3; human, Homo sapiens.
IN T05056 Max; human, Homo sapiens.
IN T09508 Mef-2a; human, Homo sapiens.
IN T16713 MEF-2C; human, Homo sapiens.
IN T04909 MOP4; human, Homo sapiens.
IN T10759 MTA-1; human, Homo sapiens.
IN T34269 NBS1; human, Homo sapiens.
IN T05875 p160MBP; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
IN T29721 Pkm2-isoform-M2; human, Homo sapiens.
IN T02336 PLZF; human, Homo sapiens.
IN T10571 Ref-1; Mammalia.
IN T08711 RelA-p65; human, Homo sapiens.
IN T10783 Smad1; Mammalia.
IN T10683 Smad2; human, Homo sapiens.
IN T24830 Smad2; Mammalia.
IN T10378 Smad3; human, Homo sapiens.
IN T04292 Smad4; human, Homo sapiens.
IN T04217 Smad7; human, Homo sapiens.
IN T05485 Sox-9; rat, Rattus norvegicus.
IN T09118 Sp1-isoform1; mouse, Mus musculus.
IN T00759 Sp1; human, Homo sapiens.
IN T02338 Sp3; human, Homo sapiens.
IN T09269 Spi-B-isoform1; human, Homo sapiens.
IN T01556 SREBP-1a; human, Homo sapiens.
IN T01492 STAT1alpha; human, Homo sapiens.
IN T25628 XPA; human, Homo sapiens.
IN T10348 YB-1; human, Homo sapiens.
XX
MX M04749 V$EP300_03.
MX M04826 V$EP300_05.
MX M04833 V$EP300_06.
MX M04868 V$EP300_07.
MX M04901 V$EP300_08.
MX M04966 V$EP300_11.
MX M00033 V$P300_01.
MX M07266 V$P300_Q5.
XX
BS R62309.
BS R35072.
BS R35073.
BS R60589.
BS R62281.
XX
DR TRANSPATH: MO000056654.
DR UniProtKB: Q09472;
XX
RN [1]; RE0017305.
RX PUBMED: 11708801.
RA Zhu M., Fahl W. E.
RT Functional characterization of transcription regulators that interact with the electrophile response element
RL Biochem. Biophys. Res. Commun. 289:212-219 (2001).
RN [2]; RE0023723.
RX PUBMED: 11864910.
RA Yamamoto H., Kihara-Negishi F., Yamada T., Suzuki M., Nakano T., Oikawa T.
RT Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb.
RL Cell Growth Differ. 13:69-75 (2002).
RN [3]; RE0026618.
RX PUBMED: 10918613.
RA Ghosh A. K., Yuan W., Mori Y., Varga J.
RT Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.
RL Oncogene 19:3546-55 (2000).
RN [4]; RE0029643.
RX PUBMED: 12015309.
RA Vieyra D., Loewith R., Scott M., Bonnefin P., Boisvert F. M., Cheema P., Pastyryeva S., Meijer M., Johnston R. N., Bazett-Jones D. P., McMahon S., Cole M. D., Young D., Riabowol K.
RT Human ING1 proteins differentially regulate histone acetylation.
RL J. Biol. Chem. 277:29832-9 (2002).
RN [5]; RE0035590.
RX PUBMED: 12917345.
RA Goel A., Janknecht R.
RT Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.
RL Mol. Cell. Biol. 23:6243-6254 (2003).
RN [6]; RE0039427.
RX PUBMED: 9606182.
RA Kitabayashi I., Yokoyama A., Shimizu K., Ohki M.
RT Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
RL EMBO J. 17:2994-3004 (1998).
RN [7]; RE0041662.
RX PUBMED: 10779504.
RA Fu M., Wang C., Reutens A. T., Wang J., Angeletti R. H., Siconolfi-Baez L., Ogryzko V., Avantaggiati M. L., Pestell R. G.
RT p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation
RL J. Biol. Chem. 275:20853-60 (2000).
RN [8]; RE0041698.
RX PUBMED: 11268218.
RA Hasan S., Hassa P. O., Imhof R., Hottiger M. O.
RT Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis
RL Nature 410:387-91 (2001).
RN [9]; RE0041699.
RX PUBMED: 12937166.
RA Hong R., Chakravarti D.
RT The human proliferating Cell nuclear antigen regulates transcriptional coactivator p300 activity and promotes transcriptional repression
RL J. Biol. Chem. 278:44505-13 (2003).
RN [10]; RE0042693.
RX PUBMED: 11430825.
RA Hasan S., Stucki M., Hassa P. O., Imhof R., Gehrig P., Hunziker P., Hubscher U., Hottiger M. O.
RT Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300
RL Mol. Cell 7:1221-31 (2001).
RN [11]; RE0042733.
RX PUBMED: 12718889.
RA Girdwood D., Bumpass D., Vaughan O. A., Thain A., Anderson L. A., Snowden A. W., Garcia-Wilson E., Perkins N. D., Hay R. T.
RT P300 transcriptional repression is mediated by SUMO modification
RL Mol. Cell 11:1043-54 (2003).
RN [12]; RE0042810.
RX PUBMED: 12408818.
RA Gronroos E., Hellman U., Heldin C. H., Ericsson J.
RT Control of Smad7 stability by competition between acetylation and ubiquitination
RL Mol. Cell 10:483-93 (2002).
RN [13]; RE0043449.
RX PUBMED: 12640139.
RA Giandomenico V., Simonsson M., Gronroos E., Ericsson J.
RT Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors
RL Mol. Cell. Biol. 23:2587-99 (2003).
RN [14]; RE0047502.
RX PUBMED: 16024799.
RA Pedeux R., Sengupta S., Shen J. C., Demidov O. N., Saito S., Onogi H., Kumamoto K., Wincovitch S., Garfield S. H., McMenamin M., Nagashima M., Grossman S. R., Appella E., Harris C. C.
RT ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation.
RL Mol. Cell. Biol. 25:6639-6648 (2005).
RN [15]; RE0047504.
RX PUBMED: 15964811.
RA Guidez F., Howell L., Isalan M., Cebrat M., Alani R. M., Ivins S., Hormaeche I., McConnell M. J., Pierce S., Cole P. A., Licht J., Zelent A.
RT Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.
RL Mol. Cell. Biol. 25:5552-5566 (2005).
RN [16]; RE0047829.
RX PUBMED: 16287840.
RA Faiola F., Liu X., Lo S., Pan S., Zhang K., Lymar E., Farina A., Martinez E.
RT Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription.
RL Mol. Cell. Biol. 25:10220-10234 (2005).
RN [17]; RE0047943.
RX PUBMED: 9343424.
RA Mink S., Haenig B., Klempnauer K. H.
RT Interaction and functional collaboration of p300 and C/EBPbeta.
RL Mol. Cell. Biol. 17:6609-6617 (1997).
RN [18]; RE0048103.
RX PUBMED: 11903055.
RA Tolnay M., Juang Y. T., Tsokos G. C.
RT Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion.
RL Biochem. J. 363:127-136 (2002).
RN [19]; RE0048120.
RX PUBMED: 12097320.
RA Lee D. K., Kim B. C., Brady J. N., Jeang K. T., Kim S. J.
RT Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element.
RL J. Biol. Chem. 277:33766-33775 (2002).
RN [20]; RE0048280.
RX PUBMED: 16434977.
RA Gong J., Zhu J., Goodman OB J. r., Pestell R. G., Schlegel P. N., Nanus D. M., Shen R.
RT Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells.
RL Oncogene 25:2011-2021 (2006).
RN [21]; RE0048366.
RX PUBMED: 16373397.
RA Li J., Fu J., Toumazou C., Yoon H. G., Wong J.
RT A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin.
RL Mol. Endocrinol. 20:776-785 (2006).
RN [22]; RE0048566.
RX PUBMED: 15572696.
RA Foulds C. E., Nelson M. L., Blaszczak A. G., Graves B. J.
RT Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.
RL Mol. Cell. Biol. 24:10954-10964 (2004).
RN [23]; RE0048582.
RX PUBMED: 11919190.
RA Czuwara-Ladykowska J., Sementchenko V. I., Watson D. K., Trojanowska M.
RT Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta.
RL J. Biol. Chem. 277:20399-20408 (2002).
RN [24]; RE0048857.
RX PUBMED: 15943588.
RA Kaida A., Ariumi Y., Baba K., Matsubae M., Takao T., Shimotohno K.
RT Identification of a novel p300-specific-associating protein, PRS1 (phosphoribosylpyrophosphate synthetase subunit 1).
RL Biochem. J. 391:239-247 (2005).
RN [25]; RE0048895.
RX PUBMED: 15563463.
RA Ishiko E., Matsumura I., Ezoe S., Gale K., Ishiko J., Satoh Y., Tanaka H., Shibayama H., Mizuki M., Era T., Enver T., Kanakura Y.
RT Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1.
RL J. Biol. Chem. 280:4929-4939 (2005).
RN [26]; RE0048931.
RX PUBMED: 12435739.
RA Bradney C., Hjelmeland M., Komatsu Y., Yoshida M., Yao T. P., Zhuang Y.
RT Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.
RL J. Biol. Chem. 278:2370-2376 (2003).
RN [27]; RE0049018.
RX PUBMED: 16024795.
RA Huang W. C., Chen C. C.
RT Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity.
RL Mol. Cell. Biol. 25:6592-6602 (2005).
RN [28]; RE0049081.
RX PUBMED: 16916644.
RA Li A. G., Piluso L. G., Cai X., Wei G., Sellers W. R., Liu X.
RT Mechanistic insights into maintenance of high p53 acetylation by PTEN.
RL Mol. Cell 23:575-587 (2006).
RN [29]; RE0049158.
RX PUBMED: 16319895.
RA Turnell A. S., Stewart G. S., Grand R. J., Rookes S. M., Martin A., Yamano H., Elledge S. J., Gallimore P. H.
RT The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.
RL Nature 438:690-695 (2005).
RN [30]; RE0049206.
RX PUBMED: 16478987.
RA Bhakat K. K., Mokkapati S. K., Boldogh I., Hazra T. K., Mitra S.
RT Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo.
RL Mol. Cell. Biol. 26:1654-1665 (2006).
RN [31]; RE0049228.
RX PUBMED: 9722503.
RA Pouponnot C., Jayaraman L., Massague J.
RT Physical and functional interaction of SMADs and p300/CBP.
RL J. Biol. Chem. 273:22865-22868 (1998).
RN [32]; RE0049236.
RX PUBMED: 11073990.
RA MacLellan W. R., Xiao G., Abdellatif M., Schneider M. D.
RT A novel Rb- and p300-binding protein inhibits transactivation by MyoD.
RL Mol. Cell. Biol. 20:8903-8915 (2000).
RN [33]; RE0049592.
RX PUBMED: 17272271.
RA Stauffer D., Chang B., Huang J., Dunn A., Thayer M.
RT P300/CBP interacts with ATR and is required for the DNA replication checkpoint.
RL J. Biol. Chem. 282:9678-9687 (2007).
RN [34]; RE0049641.
RX PUBMED: 15695103.
RA Long A. A., Chapman N. R., Innes B., Europe-Finner G. N., Robson S. C.
RT Expression and interaction of the transcriptional coregulators, CBP/p300, in the human myometrium during pregnancy and labor.
RL J. Soc. Gynecol. Invest. 12:92-97 (2005).
RN [35]; RE0049849.
RX PUBMED: 15380363.
RA Gomez-Gonzalo M., Benedicto I., Carretero M., Lara-Pezzi E., Maldonado-Rodriguez A., Moreno-Otero R., Lai M. M., Lopez-Cabrera M.
RT Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity.
RL Virology 328:120-130 (2004).
RN [36]; RE0049971.
RX PUBMED: 10655477.
RA Pao G. M., Janknecht R., Ruffner H., Hunter T., Verma I. M.
RT CBP/p300 interact with and function as transcriptional coactivators of BRCA1.
RL Proc. Natl. Acad. Sci. USA 97:1020-1025 (2000).
RN [37]; RE0049976.
RX PUBMED: 17434128.
RA Huang W. C., Ju T. K., Hung M. C., Chen C. C.
RT Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
RL Mol. Cell 26:75-87 (2007).
RN [38]; RE0049999.
RX PUBMED: 10518217.
RA Shikama N., Lee C. W., France S., Delavaine L., Lyon J., Krstic-Demonacos M., La Thangue N. B.
RT A novel cofactor for p300 that regulates the p53 response.
RL Mol. Cell 4:365-376 (1999).
RN [39]; RE0052913.
RX PUBMED: 17197080.
RA Francis Y. I., Diss J. K., Kariti M., Stephanou A., Latchman D. S.
RT p300 activation by Presenilin 1 but not by its M146L mutant.
RL Neurosci. Lett. 413:137-140 (2007).
RN [40]; RE0053001.
RX PUBMED: 11481323.
RA Vadlamudi R. K., Wang R. A., Mazumdar A., Kim Y., Shin J., Sahin A., Kumar R.
RT Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.
RL J. Biol. Chem. 276:38272-38279 (2001).
RN [41]; RE0053870.
RX PUBMED: 17923090.
RA Tang X., Gao J. S., Guan Y. J., McLane K. E., Yuan Z. L., Ramratnam B., Chin Y. E.
RT Acetylation-dependent signal transduction for type I interferon receptor.
RL Cell 131:93-105 (2007).
RN [42]; RE0054487.
RX PUBMED: 17027647.
RA Lim J. H., Cho J. Y., Park Y. B., Park J. W., Kwon T. K.
RT ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites.
RL Biochem. Biophys. Res. Commun. 350:736-741 (2006).
RN [43]; RE0054497.
RX PUBMED: 17623675.
RA Chen Y. J., Wang Y. N., Chang W. C.
RT ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression.
RL J. Biol. Chem. 282:27215-27228 (2007).
RN [44]; RE0064477.
RX PUBMED: 18083712.
RA Subbaramaiah K., Hudis C., Chang S. H., Hla T., Dannenberg A. J.
RT EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange.
RL J. Biol. Chem. 283:3433-3444 (2008).
RN [45]; RE0064497.
RX PUBMED: 18243116.
RA Kitagawa M., Lee S. H., McCormick F.
RT Skp2 suppresses p53-dependent apoptosis by inhibiting p300.
RL Mol. Cell 29:217-231 (2008).
RN [46]; RE0064873.
RX PUBMED: 18566411.
RA Liu X., Ye L., Bai Y., Mojidi H., Simister N. E., Zhu X.
RT Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG.
RL J. Immunol. 181:449-463 (2008).
RN [47]; RE0067360.
RX PUBMED: 15647279.
RA Huang W., Zhao S., Ammanamanchi S., Brattain M., Venkatasubbarao K., Freeman J. W.
RT Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex.
RL J. Biol. Chem. 280:10047-10054 (2005).
RN [48]; RE0068660.
RX PUBMED: 20228809.
RA Drost J., Mantovani F., Tocco F., Elkon R., Comel A., Holstege H., Kerkhoven R., Jonkers J., Voorhoeve P. M., Agami R., Del Sal G.
RT BRD7 is a candidate tumour suppressor gene required for p53 function.
RL Nat. Cell Biol. 12:380-389 (2010).
RN [49]; RE0070804.
RX PUBMED: 21098220.
RA Lou X., Sun S., Chen W., Zhou Y., Huang Y., Liu X., Shan Y., Wang C.
RT Negative feedback regulation of NF-kappaB action by CITED2 in the nucleus.
RL J. Immunol. 186:539-548 (2011).
RN [50]; RE0071582.
RX PUBMED: 21629263.
RA Mu Y., Sundar R., Thakur N., Ekman M., Gudey S. K., Yakymovych M., Hermansson A., Dimitriou H., Bengoechea-Alonso M. T., Ericsson J., Heldin C. H., Landstrom M.
RT TRAF6 ubiquitinates TGFbeta type I receptor to promote its cleavage and nuclear translocation in cancer.
RL Nat. Commun. 2:330 (2011).
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