AC T10378
XX
ID T10378
XX
DT 19.01.2006 (created); jma.
DT 09.06.2016 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA Smad3
XX
SY JV15-2; MAD, mothers against decapentaplegic homolog 3 (Drosophila); MADH3; SMAD3.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002399 SMAD3; HGNC: SMAD3.
XX
CL C0041; SMAD; 7.1.1.1.3.
XX
FF TGFbeta1 treatment increased the protein level [15];
FF LOX downregulates this protein [15];
XX
IN T04074 brca1; human, Homo sapiens.
IN T19409 BS69; human, Homo sapiens.
IN T09998 c-Myc; human, Homo sapiens.
IN T14435 c-Myc; Mammalia.
IN T04643 c-Ski; human, Homo sapiens.
IN T02284 ctcf; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T09368 foxm1; human, Homo sapiens.
IN T22348 NF-1; human, Homo sapiens.
IN T02767 Nur77; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T13888 pax6; Mammalia.
IN T06377 PML; human, Homo sapiens.
IN T14648 PRDII-BF1; human, Homo sapiens.
IN T04922 Prox-1; human, Homo sapiens.
IN T10683 Smad2; human, Homo sapiens.
IN T04292 Smad4; human, Homo sapiens.
IN T05485 Sox-9; rat, Rattus norvegicus.
IN T04759 STAT1; human, Homo sapiens.
IN T01493 STAT3; human, Homo sapiens.
IN T04946 TIF1g; human, Homo sapiens.
IN T27232 Tilz2; human, Homo sapiens.
XX
MX M00701 V$SMAD3_Q6.
MX M01888 V$SMAD3_Q6_01.
MX M07429 V$SMAD3_Q6_02.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
XX
BS R23224.
BS R38826.
BS R38828.
BS R38829.
BS R38830.
BS R38831.
BS R10092.
BS R39137.
BS R29592.
BS R32453.
BS R70434.
BS R68676.
BS R62063.
BS R71706.
BS R67615.
BS R33292.
BS R37758.
BS R33953.
BS R23966.
BS R24001.
BS R24272.
BS R23096.
BS R35939.
BS R70436.
BS R70440.
BS R38243.
BS R61390.
BS R73056.
BS R73055.
BS R38218.
BS R26795.
BS R26800.
BS R68163.
BS R29688.
BS R57121.
BS R69950.
BS R69951.
BS R71395.
BS R37755.
BS R29441.
BS R09967.
BS R10079.
BS R23125.
BS R38484.
BS R39162.
BS R70432.
BS R70433.
BS R23469.
BS R71597.
BS R67099.
BS R25199.
BS R21773.
BS R61576.
BS R69758.
BS R23189.
BS R30498.
BS R37792.
XX
DR TRANSPATH: MO000057832.
DR TRANSCOMPEL: C00539.
DR TRANSCOMPEL: C00557.
DR TRANSCOMPEL: C00574.
DR UniProtKB: P84022;
XX
RN [1]; RE0028090.
RX PUBMED: 11438668.
RA Furuhashi M., Yagi K., Yamamoto H., Furukawa Y., Shimada S., Nakamura Y., Kikuchi A., Miyazono K., Kato M.
RT Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway.
RL Mol. Cell. Biol. 21:5132-41 (2001).
RN [2]; RE0029751.
RX PUBMED: 12110667.
RA Cogan J. G., Subramanian S. V., Polikandriotis J. A., Kelm R. J. Jr, Strauch A. R.
RT Vascular Smooth Muscle alpha -Actin Gene Transcription during Myofibroblast Differentiation Requires Sp1/3 Protein Binding Proximal to the MCAT Enhancer.
RL J. Biol. Chem. 277:36433-42 (2002).
RN [3]; RE0031943.
RX PUBMED: 15241418.
RA Matsuura I., Denissova N. G., Wang G., He D., Long J., Liu F.
RT Cyclin-dependent kinases regulate the antiproliferative function of Smads.
RL Nature 430:226-31 (2004).
RN [4]; RE0035779.
RX PUBMED: 16109717.
RA Furumatsu T., Tsuda M., Yoshida K., Taniguchi N., Ito T., Hashimoto M., Ito T., Asahara H.
RT Sox9 and p300 cooperatively regulate chromatin-mediated transcription.
RL J. Biol. Chem. 280:35203-35208 (2005).
RN [5]; RE0035816.
RX PUBMED: 11804592.
RA Feng X. H., Liang Y. Y., Liang M., Zhai W., Lin X.
RT Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B).
RL Mol. Cell 9:133-143 (2002).
RN [6]; RE0041862.
RX PUBMED: 11555647.
RA Matsuda T., Yamamoto T., Muraguchi A., Saatcioglu F.
RT Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3
RL J. Biol. Chem. 276:42908-14 (2001).
RN [7]; RE0047880.
RX PUBMED: 15356634.
RA Lin H. K., Bergmann S., Pandolfi P. P.
RT Cytoplasmic PML function in TGF-beta signalling.
RL Nature 431:205-211 (2004).
RN [8]; RE0047884.
RX PUBMED: 14525983.
RA Wu K., Yang Y., Wang C., Davoli M. A., D'Amico M., Li A., Cveklova K., Kozmik Z., Lisanti M. P., Russell R. G., Cvekl A., Pestell R. G.
RT DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.
RL J. Biol. Chem. 278:51673-51684 (2003).
RN [9]; RE0047923.
RX PUBMED: 15798217.
RA Ray D., Terao Y., Nimbalkar D., Chu L. H., Donzelli M., Tsutsui T., Zou X., Ghosh A. K., Varga J., Draetta G. F., Kiyokawa H.
RT Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.
RL Mol. Cell. Biol. 25:3338-3347 (2005).
RN [10]; RE0047924.
RX PUBMED: 11387212.
RA Hocevar B. A., Smine A., Xu X. X., Howe P. H.
RT The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.
RL EMBO J. 20:2789-2801 (2001).
RN [11]; RE0048582.
RX PUBMED: 11919190.
RA Czuwara-Ladykowska J., Sementchenko V. I., Watson D. K., Trojanowska M.
RT Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta.
RL J. Biol. Chem. 277:20399-20408 (2002).
RN [12]; RE0049583.
RX PUBMED: 17327236.
RA Seong H. A., Jung H., Kim K. T., Ha H.
RT 3-phosphoinositide-dependent protein kinase-1 (PDK1) negatively regulates TGF-beta -induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.
RL J. Biol. Chem. 282:12272-12289 (2007).
RN [13]; RE0051123.
RX PUBMED: 15735739.
RA Dubrovska A., Kanamoto T., Lomnytska M., Heldin C. H., Volodko N., Souchelnytskyi S.
RT TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.
RL Oncogene 24:2289-2297 (2005).
RN [14]; RE0052179.
RX PUBMED: 15198928.
RA Lee H. S., Moon K. C., Song C. Y., Kim B. C., Wang S., Hong H. K.
RT Glycated albumin activates PAI-1 transcription through Smad DNA binding sites in mesangial cells.
RL Am. J. Physiol. Renal Physiol. 287:F665-72 (2004).
RN [15]; RE0052611.
RX PUBMED: 17395448.
RA Oleggini R., Gastaldo N., Di Donato A.
RT Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effects.
RL Matrix Biol. 26:494-505 (2007).
RN [16]; RE0054878.
RX PUBMED: 15661740.
RA Zhang X. L., Topley N., Ito T., Phillips A.
RT Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling.
RL J. Biol. Chem. 280:12239-12245 (2005).
RN [17]; RE0066493.
RX PUBMED: 12446380.
RA Saika S., Miyamoto T., Ishida I., Shirai K., Ohnishi Y., Ooshima A., McAvoy J. W.
RT TGFbeta-Smad signalling in postoperative human lens epithelial cells.
RL Br. J. Ophthalmol. 86:1428-1433 (2002).
RN [18]; RE0070045.
RX PUBMED: 19864455.
RA Xu Y., Baker D., Quan T., Baldassare J. J., Voorhees J. J., Fisher G. J.
RT Receptor type protein tyrosine phosphatase-kappa mediates cross-talk between transforming growth factor-beta and epidermal growth factor receptor signaling pathways in human keratinocytes.
RL Mol. Biol. Cell 21:29-35 (2010).
RN [19]; RE0071921.
RX PUBMED: 18321991.
RA Kim W., Seok Kang Y., Soo Kim J., Shin N. Y., Hanks S. K., Song W. K.
RT The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling.
RL Mol. Biol. Cell 19:2135-2146 (2008).
RN [20]; RE0072535.
RX PUBMED: 18568018.
RA Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R., Rao B. M., Dembowy J., Yaffe M. B., Zandstra P. W., Wrana J. L.
RT TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
RL Nat. Cell Biol. 10:837-848 (2008).
RN [21]; RE0073082.
RX PUBMED: 18337748.
RA Rudini N., Felici A., Giampietro C., Lampugnani M., Corada M., Swirsding K., Garre M., Liebner S., Letarte M., ten Dijke P., Dejana E.
RT VE-cadherin is a critical endothelial regulator of TGF-beta signalling.
RL EMBO J. 27:993-1004 (2008).
XX
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