TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04759 XX ID T04759 XX DT 11.09.2001 (created); vma. DT 16.05.2016 (updated); ros. CO Copyright (C), QIAGEN. XX FA STAT1 XX SY signal transducer and activator of transcription 1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004625 STAT1; HGNC: STAT1. XX CL C0039; STAT; XX SF at least two splice variants are known: STAT1alpha T01492 and STAT1beta T01573; SF binds DNA as homodimers, heterodimers with other STAT factors; SF in several cases binds to the two closely situated binding sites as a homotetramer; XX CP HL-205 and HL-525 [115]; THP1 cells [26]. XX FF mRNA and protein levels increased when HL-205 and HL-525 cells are treated with DMSO or PMA [115]; FF (binding activity) induced by IFN-gamma in various cell lines [4] [5] [6]; FF acts synergistically with NF-kappaB for activation of inflammatory genes [6]; FF directly interacts with the C-terminal region of co-activator CBP [6]; XX IN T29723 alpha-actinin-4; human, Homo sapiens. IN T00133 c-Jun; human, Homo sapiens. IN T03238 DDB1; human, Homo sapiens. IN T34781 ErbB1; human, Homo sapiens. IN T06042 HDAC4; human, Homo sapiens. IN T10036 HSF1; human, Homo sapiens. IN T00423 IRF-1; human, Homo sapiens. IN T16551 RBTN2; human, Homo sapiens. IN T01345 RXR-alpha; human, Homo sapiens. IN T04273 Smad2; mouse, Mus musculus. IN T10683 Smad2; human, Homo sapiens. IN T09072 Smad3; mouse, Mus musculus. IN T10378 Smad3; human, Homo sapiens. IN T04759 STAT1; human, Homo sapiens. IN T01494 STAT2; human, Homo sapiens. IN T01493 STAT3; human, Homo sapiens. IN T09372 STAT5; human, Homo sapiens. IN T00835 TMF; human, Homo sapiens. XX MX M00224 V$STAT1_01. MX M00492 V$STAT1_02. MX M00496 V$STAT1_03. MX M01260 V$STAT1_05. MX M04721 V$STAT1_07. MX M07228 V$STAT1_09. MX M07064 V$STAT1_Q4. MX M01823 V$STAT1_Q6. MX M00223 V$STAT_01. MX M00777 V$STAT_Q6. XX BS R11779. BS R11882. BS R11883. BS R11884. BS R11885. BS R11886. BS R11887. BS R11888. BS R11889. BS R11890. BS R11891. BS R11892. BS R11893. BS R11894. BS R11895. BS R11896. BS R11897. BS R11898. BS R11899. BS R11900. BS R11901. BS R11902. BS R11903. BS R11904. BS R11905. BS R11906. BS R11907. BS R11908. BS R11909. BS R11910. BS R11911. BS R11912. BS R11913. BS R11914. BS R11915. BS R11916. BS R11917. BS R11918. BS R11919. BS R11920. BS R11921. BS R11922. BS R11923. BS R11924. BS R11925. BS R11926. BS R11927. BS R11928. BS R11929. BS R11930. BS R11931. BS R11932. BS R23951. BS R24465. BS R25860. BS R12445. BS R24227. BS R25857. BS R29898. BS R25804. BS R63166. BS R25555. BS R14657. BS R56104. BS R15672. BS R25884. BS R12428. BS R68084. BS R13378. BS R66524. BS R67509. BS R34306. BS R72701. BS R24094. BS R11115. BS R24676. BS R25885. BS R28469. BS R29784. BS R08485. BS R38394. BS R60874. BS R60891. BS R60898. BS R60899. BS R34310. BS R22348. BS R25957. BS R26921. BS R28355. BS R25927. BS R25930. BS R16934. BS R35057. BS R26959. BS R25909. BS R11154. BS R11155. BS R22437. BS R26290. BS R26291. BS R04223. BS R13215. BS R26378. BS R29812. BS R66718. BS R66721. BS R66733. BS R66734. BS R35414. BS R29886. BS R22475. BS R66486. BS R33230. BS R25979. BS R14313. BS R25939. BS R22364. BS R27120. BS R25823. BS R42054. BS R55788. BS R55791. BS R19704. BS R16930. BS R62175. BS R62181. BS R20162. BS R26947. BS R31000. BS R61578. BS R17186. BS R26474. BS R27115. BS R64019. BS R64020. BS R16057. BS R60617. BS R20840. BS R14714. BS R14715. BS R11156. BS R11157. BS R26520. BS R25840. BS R26293. BS R19705. BS R29785. BS R29859. BS R13351. BS R22476. BS R64014. BS R04252. BS R26438. XX DR TRANSPATH: MO000019521. DR TRANSCOMPEL: C00182. DR TRANSCOMPEL: C00299. DR TRANSCOMPEL: C00414. DR TRANSCOMPEL: C00544. DR TRANSCOMPEL: C00589. DR UniProtKB: P42224; XX RN [1]; RE0003480. RX PUBMED: 7516473. RA Jiang C.-K., Flanagan S., Ohtsuki M., Shuai K., Freedberg I. M., Blumenberg M. RT Disease-activated transcription factor: Allergic reactions in human skin cause nuclear translocation of STAT-91 and induce synthesis of keratin K17 RL Mol. Cell. Biol. 14:4759-4769 (1994). RN [2]; RE0003511. RX PUBMED: 8272872. RA Luetticken C., Wegenka U.M., Yuan J., Buschmann J., Schindler C., Ziemiecki A., Harpur A. G., Wilks A. F., Yasukawa K., Taga T., Kishimoto T., Barbieri G., Pellegrini S., Sendtner M., Heinrich P. C., Horn F. RT Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 transducer gp130 RL Science 263:89-92 (1994). RN [3]; RE0012679. RX PUBMED: 8605876. RA Yan H., Krishnan K., Greenlund A. C., Gupta S., Lim J. T. E., Schreiber R. D., Schindler C. W., Krolewski J. J. RT Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein RL EMBO J. 15:1064-1074 (1996). RN [4]; RE0017511. RX PUBMED: 10866323. RA Chen B., He L., Savell V. H., Jenkins J. J., Parham D. M. RT Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermethylation at a STAT-binding site in the p21WAF1 promoter region. RL Cancer Res. 60:3290-3298 (2000). RN [5]; RE0017741. RX PUBMED: 10910100. RA Gooch J. L., Herrera R. E., Yee D. RT The role of p21 in interferon gamma-mediated growth inhibition of human breast cancer cells. RL Cell Growth Differ. 11:335-342 (2000). RN [6]; RE0024015. RX PUBMED: 12403783. RA Hiroi M., Ohmori Y. RT The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene. RL J. Biol. Chem. 278:651-660 (2003). RN [7]; RE0026427. RX PUBMED: 10748192. RA Gamero A. M., Larner A. C. RT Signaling via the T cell antigen receptor induces phosphorylation of stat1 on serine 727 RL J. Biol. Chem. 275:16574-8 (2000). RN [8]; RE0026644. RX PUBMED: 10823829. RA Zhang Y., Turkson J., Carter-Su C., Smithgall T., Levitzki A., Kraker A., Krolewski J. J., Medveczky P., Jove R. RT Activation of stat3 in v-src-transformed fibroblasts requires cooperation of jak1 kinase activity RL J. Biol. Chem. 275:24935-44 (2000). RN [9]; RE0028499. RX PUBMED: 9030543. RA Robledo O., Fourcin M., Chevalier S., Guillet C., Auguste P., Pouplard-Barthelaix A., Pennica D., Gascan H. RT Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component. RL J. Biol. Chem. 272:4855-63 (1997). RN [10]; RE0028648. RX PUBMED: 11038252. RA Halfter H., Postert C., Friedrich M., Ringelstein E. B., Stogbauer F. RT Activation of the Jak-Stat- and MAPK-pathways by oncostatin M is not sufficient to cause growth inhibition of human glioma cells. RL Brain Res. Mol. Brain Res. 80:198-206 (2000). RN [11]; RE0032571. RX PUBMED: 9880553. RA Stephanou A., Isenberg D. A., Nakajima K., Latchman D. S. RT Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters. RL J. Biol. Chem. 274:1723-8 (1999). RN [12]; RE0033178. RX PUBMED: 14645718. RA Nusinzon I., Horvath C. M. RT Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. RL Proc. Natl. Acad. Sci. USA 100:14742-7 (2003). RN [13]; RE0033943. RX PUBMED: 12817007. RA Deb D. K., Sassano A., Lekmine F., Majchrzak B., Verma A., Kambhampati S., Uddin S., Rahman A., Fish E. N., Platanias L. C. RT Activation of protein kinase C delta by IFN-gamma. RL J. Immunol. 171:267-73 (2003). RN [14]; RE0035773. RX PUBMED: 9353320. RA Koshelnick Y., Ehart M., Hufnagl P., Heinrich P. C., Binder B. R. RT Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598. RL J. Biol. Chem. 272:28563-28567 (1997). RN [15]; RE0043317. RX PUBMED: 12023369. RA Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K. P., Vega F., To W., Wagner J., O'Farrell A. M., McClanahan T., Zurawski S., Hannum C., Gorman D., Rennick D. M., Kastelein R. A., de Waal Malefyt R., Moore K. W. RT A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R RL J. Immunol. 168:5699-708 (2002). RN [16]; RE0047346. RX PUBMED: 12855578. RA Ungureanu D., Vanhatupa S., Kotaja N., Yang J., Aittomaki S., Janne O. A., Palvimo J. J., Silvennoinen O. RT PIAS proteins promote SUMO-1 conjugation to STAT1. RL Blood 102:3311-3313 (2003). RN [17]; RE0048007. RX PUBMED: 12235142. RA Shah M., Patel K., Fried V. A., Sehgal P. B. RT Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever. RL J. Biol. Chem. 277:45662-45669 (2002). RN [18]; RE0049155. RX PUBMED: 16940534. RA Lin W., Kim S. S., Yeung E., Kamegaya Y., Blackard J. T., Kim K. A., Holtzman M. J., Chung R. T. RT Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. RL J. Virol. 80:9226-9235 (2006). RN [19]; RE0049247. RX PUBMED: 15296650. RA Miller K., McArdle S., Gale MJ J. r., Geller D. A., Tenoever B., Hiscott J., Gretch D. R., Polyak S. J. RT Effects of the hepatitis C virus core protein on innate cellular defense pathways. RL J. Interferon Cytokine Res. 24:391-402 (2004). RN [20]; RE0049465. RX PUBMED: 16273093. RA Jones R. B., Gordus A., Krall J. A., MacBeath G. RT A quantitative protein interaction network for the ErbB receptors using protein microarrays. RL Nature 439:168-174 (2006). RN [21]; RE0049934. RX PUBMED: 15825084. RA Lin W., Choe W. H., Hiasa Y., Kamegaya Y., Blackard J. T., Schmidt E. V., Chung R. T. RT Hepatitis C virus expression suppresses interferon signaling by degrading STAT1. RL Gastroenterology 128:1034-1041 (2005). RN [22]; RE0049936. RX PUBMED: 17275127. RA Lan K. H., Lan K. L., Lee W. P., Sheu M. L., Chen M. Y., Lee Y. L., Yen S. H., Chang F. Y., Lee S. D. RT HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines. RL J. Hepatology 46:759-767 (2007). RN [23]; RE0050787. RX PUBMED: 14498832. RA Zhang T., Ma J., Cao X. RT Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling. RL Biochem. J. 376:457-464 (2003). RN [24]; RE0052120. RX PUBMED: 9212064. RA Han Y., Watling D., Rogers N. C., Stark G. R. RT JAK2 and STAT5, but not JAK1 and STAT1, are required for prolactin-induced beta-lactoglobulin transcription. RL Mol. Endocrinol. 11:1180-1188 (1997). RN [25]; RE0052809. RX PUBMED: 7537736. RA Lebrun J. J., Ali S., Ullrich A., Kelly P. A. RT Proline-rich sequence-mediated Jak2 association to the prolactin receptor is required but not sufficient for signal transduction. RL J. Biol. Chem. 270:10664-10670 (1995). RN [26]; RE0052817. RX PUBMED: 11477089. RA Sakamoto S., Taniguchi T. RT Identification of a phorbol ester-responsive element in the interferon-gamma receptor 1 chain gene. RL J. Biol. Chem. 276:37237-37241 (2001). RN [27]; RE0053344. RX PUBMED: 17114005. RA Schust J., Sperl B., Hollis A., Mayer T. U., Berg T. RT Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. RL Chem. Biol. 13:1235-1242 (2006). RN [28]; RE0053419. RX PUBMED: 14551204. RA Sandberg E. M., Ma X., VonDerLinden D., Godeny M. D., Sayeski P. P. RT Jak2 tyrosine kinase mediates angiotensin II-dependent inactivation of ERK2 via induction of mitogen-activated protein kinase phosphatase 1. RL J. Biol. Chem. 279:1956-1967 (2004). RN [29]; RE0053951. RX PUBMED: 14511121. RA Kaur N., Kim I. J., Higgins D., Halvorsen S. W. RT Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines. RL J. Neurochem 87:437-447 (2003). RN [30]; RE0053982. RX PUBMED: 18430728. RA Hintzen C., Evers C., Lippok B. E., Volkmer R., Heinrich P. C., Radtke S., Hermanns H. M. RT Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation. RL J. Biol. Chem. 283:19465-19477 (2008). RN [31]; RE0054878. RX PUBMED: 15661740. RA Zhang X. L., Topley N., Ito T., Phillips A. RT Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. RL J. Biol. Chem. 280:12239-12245 (2005). RN [32]; RE0054958. RX PUBMED: 10922477. RA Terstegen L., Maassen B. G., Radtke S., Behrmann I., Schaper F., Heinrich P. C., Graeve L., Gatsios P. RT Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA. RL FEBS Lett. 478:100-104 (2000). RN [33]; RE0055012. RX PUBMED: 18471880. RA Dong L. W., Kong X. N., Yan H. X., Yu L. X., Chen L., Yang W., Liu Q., Huang D. D., Wu M. C., Wang H. Y. RT Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction. RL Mol. Immunol. 45:3025-3035 (2008). RN [34]; RE0055234. RX PUBMED: 19115200. RA Barclay J. L., Anderson S. T., Waters M. J., Curlewis J. D. RT SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL. RL Int. J. Cancer 124:1756-1766 (2008). RN [35]; RE0055547. RX PUBMED: 11032019. RA Llovera M., Pichard C., Bernichtein S., Jeay S., Touraine P., Kelly P. A., Goffin V. RT Human prolactin (hPRL) antagonists inhibit hPRL-activated signaling pathways involved in breast cancer cell proliferation. RL Oncogene 19:4695-4705 (2000). RN [36]; RE0063497. RX PUBMED: 18192275. RA Bai Y., Ahmad U., Wang Y., Li J. H., Choy J. C., Kim R. W., Kirkiles-Smith N., Maher S. E., Karras J. G., Bennett C. F., Bothwell A. L., Pober J. S., Tellides G. RT Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. RL J. Biol. Chem. 283:6832-6842 (2008). RN [37]; RE0063586. RX PUBMED: 17823654. RA Cheriyath V., Glaser K. B., Waring J. F., Baz R., Hussein M. A., Borden E. C. RT G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. RL J. Clin. Invest. 117:3107-3117 (2007). RN [38]; RE0063960. RX PUBMED: 18556463. RA Madonna S., Scarponi C., De Pita O., Albanesi C. RT Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation. RL FASEB J. 22:3287-3297 (2008). RN [39]; RE0063965. RX PUBMED: 18694960. RA Moschonas A., Kouraki M., Knox P. G., Thymiakou E., Kardassis D., Eliopoulos A. G. RT CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. RL Mol. Cell. Biol. 28:6208-6222 (2008). RN [40]; RE0064019. RX PUBMED: 19231233. RA Seo J. Y., Kim D. Y., Lee Y. S., Ro J. Y. RT Cytokine production through PKC/p38 signaling pathways, not through JAK/STAT1 pathway, in mast cells stimulated with IFNgamma. RL Cytokine 46:51-60 (2009). RN [41]; RE0064089. RX PUBMED: 18789440. RA Hao X. R., Cao D. L., Hu Y. W., Li X. X., Liu X. H., Xiao J., Liao D. F., Xiang J., Tang C. K. RT IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner. RL Atherosclerosis 203:417-428 (2009). RN [42]; RE0064130. RX PUBMED: 18362173. RA Flex E., Petrangeli V., Stella L., Chiaretti S., Hornakova T., Knoops L., Ariola C., Fodale V., Clappier E., Paoloni F., Martinelli S., Fragale A., Sanchez M., Tavolaro S., Messina M., Cazzaniga G., Camera A., Pizzolo G., Tornesello A., Vignetti M., Battistini A., Cave H., Gelb B. D., Renauld J. C., Biondi A., Constantinescu S. N., Foa R., Tartaglia M. RT Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. RL J. Exp. Med. 205:751-758 (2008). RN [43]; RE0064287. RX PUBMED: 16670329. RA Yu Y., Nagai S., Wu H., Neish A. S., Koyasu S., Gewirtz A. T. RT TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression. RL J. Immunol. 176:6194-6201 (2006). RN [44]; RE0064295. RX PUBMED: 17617590. RA Albanesi C., Fairchild H. R., Madonna S., Scarponi C., De Pita O., Leung D. Y., Howell M. D. RT IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3. RL J. Immunol. 179:984-992 (2007). RN [45]; RE0064656. RX PUBMED: 18832710. RA Baron M., Davignon J. L. RT Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2. RL J. Immunol. 181:5530-5536 (2008). RN [46]; RE0064666. RX PUBMED: 19592490. RA Wort S. J., Ito M., Chou P. C., Mc Master S. K., Badiger R., Jazrawi E., de Souza P., Evans T. W., Mitchell J. A., Pinhu L., Ito K., Adcock I. M. RT Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites. RL J. Biol. Chem. 284:24297-24305 (2009). RN [47]; RE0064765. RX PUBMED: 17653195. RA Malathi K., Dong B., Gale M J. r., Silverman R. H. RT Small self-RNA generated by RNase L amplifies antiviral innate immunity. RL Nature 448:816-819 (2007). RN [48]; RE0064832. RX PUBMED: 19543380. RA Delaloye J., Roger T., Steiner-Tardivel Q. G., Le Roy D., Knaup Reymond M., Akira S., Petrilli V., Gomez C. E., Perdiguero B., Tschopp J., Pantaleo G., Esteban M., Calandra T. RT Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. RL PLoS Pathog. 5:e1000480 (2009). RN [49]; RE0064975. RX PUBMED: 19776010. RA McGillicuddy F. C., Chiquoine E. H., Hinkle C. C., Kim R. J., Shah R., Roche H. M., Smyth E. M., Reilly M. P. RT Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. RL J. Biol. Chem. 284:31936-31944 (2009). RN [50]; RE0065006. RX PUBMED: 19074829. RA McGough J. M., Yang D., Huang S., Georgi D., Hewitt S. M., Rocken C., Tanzer M., Ebert M. P., Liu K. RT DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells. RL Mol. Cancer Res. 6:1841-1851 (2008). RN [51]; RE0065057. RX PUBMED: 16280321. RA Shang L., Tomasi T. B. RT The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. RL J. Biol. Chem. 281:1876-1884 (2006). RN [52]; RE0065065. RX PUBMED: 15604419. RA Huang A., Zhang Y. Y., Chen K., Hatakeyama K., Keaney JF J. r. RT Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3. RL Circ. Res. 96:164-171 (2005). RN [53]; RE0065138. RX PUBMED: 16710296. RA Malakhova O. A., Kim K. I., Luo J. K., Zou W., Kumar K. G., Fuchs S. Y., Shuai K., Zhang D. E. RT UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. RL EMBO J. 25:2358-2367 (2006). RN [54]; RE0065158. RX PUBMED: 18281489. RA Wang Y., Liu D., Chen P., Koeffler H. P., Tong X., Xie D. RT Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers. RL Cancer Res. 68:1136-1143 (2008). RN [55]; RE0065187. RX PUBMED: 17237409. RA Choi J. C., Holtz R., Petroff M. G., Alfaidy N., Murphy S. P. RT Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway. RL J. Immunol. 178:1598-1607 (2007). RN [56]; RE0065217. RX PUBMED: 19508864. RA Cho H. J., Jin S. M., Son S. M., Kim Y. W., Hwang J. Y., Hong H. S., Mook-Jung I. RT Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons. RL Biochem. Biophys. Res. Commun. 386:175-180 (2009). RN [57]; RE0065312. RX PUBMED: 19846878. RA Barnholt K. E., Kota R. S., Aung H. H., Rutledge J. C. RT Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation. RL J. Immunol. 183:6767-6777 (2009). RN [58]; RE0065331. RX PUBMED: 19542364. RA Tsai C. C., Kai J. I., Huang W. C., Wang C. Y., Wang Y., Chen C. L., Fang Y. T., Lin Y. S., Anderson R., Chen S. H., Tsao C. W., Lin C. F. RT Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2. RL J. Immunol. 183:856-864 (2009). RN [59]; RE0065354. RX PUBMED: 19404947. RA Karonitsch T., Feierl E., Steiner C. W., Dalwigk K., Korb A., Binder N., Rapp A., Steiner G., Scheinecker C., Smolen J., Aringer M. RT Activation of the interferon-gamma signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells. RL Arthritis Rheum. 60:1463-1471 (2009). RN [60]; RE0065411. RX PUBMED: 19478064. RA Cheon H., Stark G. R. RT Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. RL Proc. Natl. Acad. Sci. USA 106:9373-9378 (2009). RN [61]; RE0065419. RX PUBMED: 17204547. RA Brand S., Dambacher J., Beigel F., Zitzmann K., Heeg M. H., Weiss T. S., Prufer T., Olszak T., Steib C. J., Storr M., Goke B., Diepolder H., Bilzer M., Thasler W. E., Auernhammer C. J. RT IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro. RL Am. J. Physiol. Gastrointest. Liver Physiol. 292:G1019-28 (2007). RN [62]; RE0065435. RX PUBMED: 17579625. RA Fojtova M., Boudny V., Kovarik A., Lauerova L., Adamkova L., Souckova K., Jarkovsky J., Kovarik J. RT Development of IFN-gamma resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells. RL Br. J. Cancer 97:231-237 (2007). RN [63]; RE0065525. RX PUBMED: 17438334. RA Ziesche E., Bachmann M., Kleinert H., Pfeilschifter J., Muhl H. RT The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells. RL J. Biol. Chem. 282:16006-16015 (2007). RN [64]; RE0065532. RX PUBMED: 14978237. RA Chang Y. J., Holtzman M. J., Chen C. C. RT Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1. RL Mol. Pharmacol. 65:589-598 (2004). RN [65]; RE0065662. RX PUBMED: 16000408. RA Du Z., Shen Y., Yang W., Mecklenbrauker I., Neel B. G., Ivashkiv L. B. RT Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway. RL Proc. Natl. Acad. Sci. USA 102:10267-10272 (2005). RN [66]; RE0065689. RX PUBMED: 18606657. RA Gerber S. A., Pober J. S. RT IFN-alpha induces transcription of hypoxia-inducible factor-1alpha to inhibit proliferation of human endothelial cells. RL J. Immunol. 181:1052-1062 (2008). 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