AC T09372
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ID T09372
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DT 21.11.2000 (created); mkl.
DT 08.09.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA STAT5
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SY Signal Transducer and Activator of Transcription 1; signal transducer and activator of transcription 5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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FF PI 3-kinase regulates sub cellular localization of STAT5 [2];
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IN T04759 STAT1; human, Homo sapiens.
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BS R23711.
BS R24145.
BS R64635.
BS R26233.
BS R64405.
BS R64406.
BS R12435.
BS R31349.
BS R26866.
BS R34048.
BS R25927.
BS R25930.
BS R14444.
BS R29752.
BS R11154.
BS R11155.
BS R74053.
BS R74054.
BS R74055.
BS R26378.
BS R25470.
BS R25471.
BS R69554.
BS R19538.
BS R25938.
BS R25939.
BS R62353.
BS R63105.
BS R13351.
XX
DR TRANSPATH: MO000019528.
DR TRANSCOMPEL: C00313.
DR TRANSCOMPEL: C00314.
DR TRANSCOMPEL: C00315.
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RN [1]; RE0023743.
RX PUBMED: 10657627.
RA Alsayed Y., Uddin S., Ahmad S., Majchrzak B., Druker B. J., Fish E. N., Platanias L. C.
RT IFN-gamma activates the C3G/Rap1 signaling pathway.
RL J. Immunol. 164:1800-1806 (2000).
RN [2]; RE0029138.
RX PUBMED: 11756417.
RA Kirito K., Watanabe T., Sawada K., Endo H., Ozawa K., Komatsu N.
RT Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways.
RL J. Biol. Chem. 277:8329-37 (2002).
RN [3]; RE0029945.
RX PUBMED: 12435740.
RA Kovanen P. E., Rosenwald A., Fu J., Hurt E. M., Lam L. T., Giltnane J. M., Wright G., Staudt L. M., Leonard W. J.
RT Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling.
RL J. Biol. Chem. 278:5205-13 (2003).
RN [4]; RE0030649.
RX PUBMED: 10618497.
RA Storz P., Doppler H., Pfizenmaier K., Muller G.
RT Insulin selectively activates STAT5b, but not STAT5a, via a JAK2-independent signalling pathway in Kym-1 rhabdomyosarcoma cells.
RL FEBS Lett. 464:159-63 (1999).
RN [5]; RE0043317.
RX PUBMED: 12023369.
RA Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K. P., Vega F., To W., Wagner J., O'Farrell A. M., McClanahan T., Zurawski S., Hannum C., Gorman D., Rennick D. M., Kastelein R. A., de Waal Malefyt R., Moore K. W.
RT A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
RL J. Immunol. 168:5699-708 (2002).
RN [6]; RE0046475.
RX PUBMED: 12552091.
RA Leung K. C., Doyle N., Ballesteros M., Sjogren K., Watts C. K., Low T. H., Leong G. M., Ross R. J., Ho K. K.
RT Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
RL Proc. Natl. Acad. Sci. USA 100:1016-21 (2003).
RN [7]; RE0047362.
RX PUBMED: 9837784.
RA Ota J., Kimura F., Sato K., Wakimoto N., Nakamura Y., Nagata N., Suzu S., Yamada M., Shimamura S., Motoyoshi K.
RT Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin.
RL Biochem. Biophys. Res. Commun. 252:779-786 (1998).
RN [8]; RE0047580.
RX PUBMED: 15728479.
RA Suh H. S., Kim M. O., Lee S. C.
RT Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt.
RL J. Immunol. 174:2712-2719 (2005).
RN [9]; RE0048114.
RX PUBMED: 10926930.
RA Du J., Alsayed Y. M., Xin F., Ackerman S. J., Platanias L. C.
RT Engagement of the CrkL adapter in interleukin-5 signaling in eosinophils.
RL J. Biol. Chem. 275:33167-33175 (2000).
RN [10]; RE0048132.
RX PUBMED: 9845531.
RA Ozaki K., Oda A., Wakao H., Rhodes J., Druker B. J., Ishida A., Wakui M., Okamoto S., Morita K., Handa M., Komatsu N., Ohashi H., Miyajima A., Ikeda Y.
RT Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets.
RL Blood 92:4652-4662 (1998).
RN [11]; RE0048396.
RX PUBMED: 16818466.
RA Presnell S. R., Zhang L., Ramilo C. A., Chan H. W., Lutz C. T.
RT Functional redundancy of transcription factor-binding sites in the killer cell Ig-like receptor (KIR) gene promoter.
RL Int. Immunol. 18:1221-1232 (2006).
RN [12]; RE0050594.
RX PUBMED: 17671194.
RA Lahusen T., Fereshteh M., Oh A., Wellstein A., Riegel A. T.
RT Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.
RL Cancer Res. 67:7256-7265 (2007).
RN [13]; RE0052093.
RX PUBMED: 9202403.
RA Pezet A., Buteau H., Kelly P. A., Edery M.
RT The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor.
RL Mol. Cell. Endocrinol. 129:199-208 (1997).
RN [14]; RE0052120.
RX PUBMED: 9212064.
RA Han Y., Watling D., Rogers N. C., Stark G. R.
RT JAK2 and STAT5, but not JAK1 and STAT1, are required for prolactin-induced beta-lactoglobulin transcription.
RL Mol. Endocrinol. 11:1180-1188 (1997).
RN [15]; RE0053982.
RX PUBMED: 18430728.
RA Hintzen C., Evers C., Lippok B. E., Volkmer R., Heinrich P. C., Radtke S., Hermanns H. M.
RT Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation.
RL J. Biol. Chem. 283:19465-19477 (2008).
RN [16]; RE0054613.
RX PUBMED: 17726024.
RA Gong Y., Ishida-Takahashi R., Villanueva E. C., Fingar D. C., Munzberg H., Myers MG J. r.
RT The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms.
RL J. Biol. Chem. 282:31019-31027 (2007).
RN [17]; RE0054771.
RX PUBMED: 9813039.
RA Lange C. A., Richer J. K., Shen T., Horwitz K. B.
RT Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways.
RL J. Biol. Chem. 273:31308-31316 (1998).
RN [18]; RE0055234.
RX PUBMED: 19115200.
RA Barclay J. L., Anderson S. T., Waters M. J., Curlewis J. D.
RT SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL.
RL Int. J. Cancer 124:1756-1766 (2008).
RN [19]; RE0055268.
RX PUBMED: 17550976.
RA Neilson L. M., Zhu J., Xie J., Malabarba M. G., Sakamoto K., Wagner K. U., Kirken R. A., Rui H.
RT Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.
RL Mol. Endocrinol. 21:2218-2232 (2007).
RN [20]; RE0062677.
RX PUBMED: 17921143.
RA Pilecka I., Patrignani C., Pescini R., Curchod M. L., Perrin D., Xue Y., Yasenchak J., Clark A., Magnone M. C., Zaratin P., Valenzuela D., Rommel C., Hooft van Huijsduijnen R.
RT Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.
RL J. Biol. Chem. 282:35405-35415 (2007).
RN [21]; RE0065249.
RX PUBMED: 16951370.
RA Rahman M. S., Yamasaki A., Yang J., Shan L., Halayko A. J., Gounni A. S.
RT IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways.
RL J. Immunol. 177:4064-4071 (2006).
RN [22]; RE0065374.
RX PUBMED: 19654410.
RA Beekman J. M., Verhagen L. P., Geijsen N., Coffer P. J.
RT Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output.
RL Blood 114:3917-3927 (2009).
RN [23]; RE0065419.
RX PUBMED: 17204547.
RA Brand S., Dambacher J., Beigel F., Zitzmann K., Heeg M. H., Weiss T. S., Prufer T., Olszak T., Steib C. J., Storr M., Goke B., Diepolder H., Bilzer M., Thasler W. E., Auernhammer C. J.
RT IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro.
RL Am. J. Physiol. Gastrointest. Liver Physiol. 292:G1019-28 (2007).
RN [24]; RE0066623.
RX PUBMED: 18456658.
RA Gakovic M., Ragimbeau J., Francois V., Constantinescu S. N., Pellegrini S.
RT The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor.
RL J. Biol. Chem. 283:18522-18529 (2008).
RN [25]; RE0067067.
RX PUBMED: 20388118.
RA Stevens C. N., Simeone A. M., John S., Ahmed Z., Lucherini O. M., Baldari C. T., Ladbury J. E.
RT T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation.
RL Biochem. J. 428:429-437 (2010).
RN [26]; RE0067727.
RX PUBMED: 19565514.
RA Hintzen C., Quaiser S., Pap T., Heinrich P. C., Hermanns H. M.
RT Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis.
RL Arthritis Rheum. 60:1932-1943 (2009).
RN [27]; RE0068014.
RX PUBMED: 18179886.
RA Arita K., South A. P., Hans-Filho G., Sakuma T. H., Lai-Cheong J., Clements S., Odashiro M., Odashiro D. N., Hans-Neto G., Hans N. R., Holder M. V., Bhogal B. S., Hartshorne S. T., Akiyama M., Shimizu H., McGrath J. A.
RT Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis.
RL Am. J. Hum. Genet. 82:73-80 (2008).
RN [28]; RE0068111.
RX PUBMED: 15194700.
RA Dreuw A., Radtke S., Pflanz S., Lippok B. E., Heinrich P. C., Hermanns H. M.
RT Characterization of the signaling capacities of the novel gp130-like cytokine receptor.
RL J. Biol. Chem. 279:36112-36120 (2004).
RN [29]; RE0070066.
RX PUBMED: 20696842.
RA Martin P., Gomez M., Lamana A., Cruz-Adalia A., Ramirez-Huesca M., Ursa M. A., Yanez-Mo M., Sanchez-Madrid F.
RT CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation.
RL Mol. Cell. Biol. 30:4877-4889 (2010).
RN [30]; RE0070259.
RX PUBMED: 21076058.
RA Yu R. Y., Gallagher G.
RT A naturally occurring, soluble antagonist of human IL-23 inhibits the development and in vitro function of human Th17 cells.
RL J. Immunol. 185:7302-7308 (2010).
RN [31]; RE0070526.
RX PUBMED: 20543098.
RA Lee S. H., Yun S., Piao Z. H., Jeong M., Kim D. O., Jung H., Lee J., Kim M. J., Kim M. S., Chung J. W., Kim T. D., Yoon S. R., Greenberg P. D., Choi I.
RT Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.
RL J. Immunol. 185:917-928 (2010).
RN [32]; RE0070958.
RX PUBMED: 21829342.
RA Beyer T., Busse M., Hristov K., Gurbiel S., Smida M., Haus U. U., Ballerstein K., Pfeuffer F., Weismantel R., Schraven B., Lindquist J. A.
RT Integrating signals from the T-cell receptor and the interleukin-2 receptor.
RL PLoS Comput. Biol. 7:e1002121 (2011).
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