AC T00133
XX
ID T00133
XX
DT 15.10.1992 (created); ewi.
DT 04.06.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA c-Jun
XX
SY AP1; c-Jun; JunA; p39; p39-jun.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G000219 JUN; HGNC: JUN.
XX
CL C0008; bZIP; 1.1.1.1.1.
XX
SF structural properties have been investigated by CD and fluorescence spectroscopy [40];
SF 1H-NMR spectroscopy [42] [63];
SF 15N-NMR [46];
SF and co-crystallization of c-Jun-DNA complexes [68];
SF c-Jun homodimerizes through the leucine zipper motif [32];
SF at least three leucine residues and some additional residues of the zipper region are important for dimerization [11];
SF heterodimers with c-Fos are more stable than homodimers [11];
SF two zipper motifs associate in a parallel manner forming a coiled-coil structure [42];
SF zipper dimerization juxtaposes the basic regions to form a contiguous DNA-binding interface [32];
SF upon DNA-binding, the basic regions adopt alpha-helical conformation to form a long helix along with that of the zipper regions [68];
SF the heterodimer with c-Fos binds 25-fold more efficiently to DNA than the homodimer [3];
SF no specific orientation of the heterodimer upon binding to the TGAGTCA recognition sequence [68];
SF preferential binding of homo- and c-Fos-heterodimers to TREs, but some promiscuity for CREs has been found as well [1] [49];
SF the leucine zipper region interacts also with the Rel domain of RelA [69];
SF the bZP domain targets the second trans-activating domain of E2A proteins when repressing their activation potential [72];
SF the regulatory regions delta and epsilon may interact with other proteins [40] [41];
SF delta may play an essential role in the interaction of c-Jun with a protein kinase [58];
SF activation domain A1 is composed of a1 and epsilon [41];
SF activation domain A2 is enriched in acidic and proline residues and is embedded in a glutamine and proline rich environment [2] [71];
SF interaction with SMAD-3 T04096 and SMAD-4 T04292 through the SMAD-binding site [77];
XX
CP ubiquitous; BL-13 and HT1376 cells [85]; EGF treated JEG-3 cells [133]; Highly expressed in 184B5/HER-2 breast cancer cells than in 184B5 cells [105]; MCF-7 + E2 [106].
CN Macrophages, U937 [134].
XX
FF Up-regulated by salvicine, a topoisomerase II inhibitor [132];
FF activator, in particular of genes required for DNA synthesis and cell proliferation [55];
FF in some case may activate gene transcription without direct binding to DNA, through protein-protein interactions with Sp1 [82];
FF weaker trans-activator than v-Jun due to regulatory domain delta [2] [40];
FF direct interactions with coactivator CBP/p300 [79];
FF inhibits myogenesis by direct interaction with MyoD [38];
FF exhibits transforming activity which is enhanced by c-Fos, but inhibited by JunB [54];
FF inducible by UV and H2O2 through a Raf-1 dependent pathway [60] [61];
FF activity is redox-regulated via oxidation of Cys-269 which involves Ref-1 as redox component [52];
FF AP-1 activity declines during cell ageing, possibly due to loss of reducing potential [55];
FF mediates gene activation synergistically with c-Jun in response to FGF / Ras and cAMP, but only the former enhances c-Jun protein levels [73];
FF target of a signalling cascade starting with Ha-Ras and resulting in c-Jun phosphorylation on Ser-63 and Ser-73 by JNK or ERK protein kinases [50] [51] [53] [59] [62] [64];
FF this phosphorylation is stimulated by phorbol esters and enhances trans-activation by c-Jun [48] [50] [58];
FF phosphorylation of Thr-231, -239, Ser-243 and -249 by GSK3, DNA-PK, CK II, or others inhibits DNA-binding [44] [57] [4];
FF this inhibitory phosphorylation is rapidly reversed after activation of PKC and subsequent modification of the N-terminal phosphorylation sites [4];
FF c-Jun inhibits GR;
FF DNA-binding is inhibited by RAR, possibly by direct interaction through the RAR-DNA binding domain;
FF it is also repressed by T3R-alpha;
FF inhibition by RAR/T3R is abrogated by v-ErbA;
FF enhanced mRNA levels after thrombin treatment, 2 maxima after 0.5 and 12h [36];
FF significant enhancement of dimerization by Tax;
FF adenoviral E1A interacts with c-Jun in particular when present in a heterodimer with CRE-BP1/ATF-2 which subsequently induces the c-jun gene through its distal AP-1 site [43];
FF HBV trans-activator pX influence phosphorylation of the DNA-binding domain and induces DNA-binding of the c-Fos/c-Jun heterodimer [47];
XX
IN T00015 AFP1; human, Homo sapiens.
IN T29723 alpha-actinin-4; human, Homo sapiens.
IN T06598 AML-1; mouse, Mus musculus.
IN T08443 AML3; mouse, Mus musculus.
IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T01017 ATF-2-isoform2; mouse, Mus musculus.
IN T01382 ATF-2; rat, Rattus norvegicus.
IN T10136 ATF-2; human, Homo sapiens.
IN T01313 ATF-3-isoform1; human, Homo sapiens.
IN T01095 ATF-3; rat, Rattus norvegicus.
IN T01303 ATF-4; human, Homo sapiens.
IN T00051 ATF; human, Homo sapiens.
IN T06579 batf3; rat, Rattus norvegicus.
IN T04074 brca1; human, Homo sapiens.
IN T00122 c-Fos; mouse, Mus musculus.
IN T00123 c-Fos; human, Homo sapiens.
IN T00124 c-Fos; rat, Rattus norvegicus.
IN T00125 c-Fos; chick, Gallus gallus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00108 C/EBPalpha-isoform1; rat, Rattus norvegicus.
IN T00581 C/EBPbeta; human, Homo sapiens.
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T18378 CBP; human, Homo sapiens.
IN T28745 chd2; human, Homo sapiens.
IN T08562 CREB1; human, Homo sapiens.
IN T01308 CREBPA; human, Homo sapiens.
IN T02198 deltaFosB; mouse, Mus musculus.
IN T00967 E1A 12S protein; adenovirus.
IN T00209 E1A 13S protein; adenovirus type 2.
IN T01376 E7; HPV-16, human papilloma virus type 16.
IN T01113 Elf-1; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T22597 FLIL; human, Homo sapiens.
IN T00291 FosB; mouse, Mus musculus.
IN T08993 FOSB; human, Homo sapiens.
IN T00292 Fra-1; mouse, Mus musculus.
IN T01208 Fra-1; rat, Rattus norvegicus.
IN T30386 Fra-1; Mammalia.
IN T01990 Fra-2; chick, Gallus gallus.
IN T00337 GR-alpha; human, Homo sapiens.
IN T01920 GR-beta; human, Homo sapiens.
IN T00333 GR; rat, Rattus norvegicus.
IN T00334 GR; chick, Gallus gallus.
IN T00335 GR; mouse, Mus musculus.
IN T00336 GR; cat, Felis silvestris catus.
IN T01610 HIF-1alpha; human, Homo sapiens.
IN T06578 jdp2; rat, Rattus norvegicus.
IN T00441 KRC; human, Homo sapiens.
IN T04870 MafG; human, Homo sapiens.
IN T19074 MLL3; human, Homo sapiens.
IN T01082 NRL; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T06377 PML; human, Homo sapiens.
IN T10799 PSIP1; human, Homo sapiens.
IN T04878 Ref-1; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
IN T04759 STAT1; human, Homo sapiens.
IN T01493 STAT3; human, Homo sapiens.
IN T14458 STAT3; Mammalia.
IN T17428 TFIIB; Mammalia.
IN T24918 TST1; human, Homo sapiens.
IN T00888 v-Fos; FBR MuLV, FBR murine osteosarcoma virus.
IN T08660 YY1; human, Homo sapiens.
IN T04355 zhx1; human, Homo sapiens.
XX
MX M00172 V$AP1FJ_Q2.
MX M00517 V$AP1_01.
MX M02280 V$AP1_02.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M03541 V$CJUN_Q6.
MX M00041 V$CREBP1CJUN_01.
MX M04879 V$JUN_02.
MX M07101 V$JUN_03.
MX M07102 V$JUN_04.
MX M08776 V$JUN_05.
XX
BS R02963.
BS R03082.
BS R03533.
BS R20747.
BS R25003.
BS R23156.
BS R24028.
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BS R25018.
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BS R72604.
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BS R08483.
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BS R38717.
BS R42519.
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BS R62790.
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BS R00235.
BS R09882.
BS R24701.
BS R25170.
BS R26528.
BS R28553.
BS R34213.
BS R55780.
BS R55786.
BS R55789.
BS R25055.
BS R34900.
BS R73091.
BS R15813.
BS R15814.
BS R40491.
BS R40652.
BS R01037.
BS R26884.
BS R40078.
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BS R18404.
BS R32816.
BS R67583.
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BS R72631.
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BS R01258.
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BS R36611.
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BS R67340.
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BS R70819.
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BS R18127.
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BS R01358.
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BS R01384.
BS R01394.
BS R01412.
XX
DR TRANSPATH: MO000019469.
DR TRANSCOMPEL: C00191.
DR TRANSCOMPEL: C00195.
DR TRANSCOMPEL: C00318.
DR TRANSCOMPEL: C00347.
DR TRANSCOMPEL: C00381.
DR TRANSCOMPEL: C00397.
DR TRANSCOMPEL: C00416.
DR TRANSCOMPEL: C00420.
DR TRANSCOMPEL: C00421.
DR TRANSCOMPEL: C00440.
DR TRANSCOMPEL: C00495.
DR UniProtKB: P05412;
DR PDB: 1FOS.
DR PDB: 1JUN.
XX
RN [1]; RE0000050.
RX PUBMED: 3034432.
RA Angel P., Imagawa M., Chiu R., Stein B., Imbra R. J., Rahmsdorf H. J., Jonat C., Herrlich P., Karin M.
RT Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
RL Cell 49:729-739 (1987).
RN [2]; RE0000124.
RX PUBMED: 2510934.
RA Bohmann D., Tjian R.
RT Biochemical analysis of transcriptional activation by Jun: Differential activity of c- and v-Jun
RL Cell 59:709-717 (1989).
RN [3]; RE0000144.
RX PUBMED: 3142692.
RA Halazonetis T. D., Georgopoulos K., Greenberg M. E., Leder P.
RT c-jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities
RL Cell 55:917-924 (1988).
RN [4]; RE0000157.
RX PUBMED: 1846781.
RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett G. R., Karin M., Hunter T.
RT Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
RL Cell 64:573-584 (1991).
RN [5]; RE0000158.
RX PUBMED: 1900458.
RA Auwerx J., Sassone-Corsi P.
RT IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation
RL Cell 64:983-993 (1991).
RN [6]; RE0000166.
RX PUBMED: 2124518.
RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P.
RT Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex
RL Cell 63:1267-1276 (1990).
RN [7]; RE0000247.
RX PUBMED: 2169353.
RA Schuele R., Rangarajan P., Kliewer S., Ransone L. J., Bolado J., Yang N., Verma I. M., Evans R. M.
RT Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
RL Cell 62:1217-1226 (1990).
RN [8]; RE0000248.
RX PUBMED: 2169352.
RA Yang-Yen H.-F., Chambard J.-C., Sun Y.-L., Smeal T., Schmidt T. J., Drouin J., Karin M.
RT Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction
RL Cell 62:1205-1215 (1990).
RN [9]; RE0000269.
RX PUBMED: 1682056.
RA Desbois C., Aubert D., Legrand C., Pain B., Samarut J.
RT A novel mechanism of action for v-erbA: abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors
RL Cell 67:731-740 (1991).
RN [10]; RE0000521.
RX PUBMED: 1714380.
RA de Groot R. P., Karperien M., Pals C., Kruijer W.
RT Characterization of the mouse junD promoter - high basal level activity due to an octamer motif
RL EMBO J. 10:2523-2532 (1991).
RN [11]; RE0000636.
RX PUBMED: 2501150.
RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M.
RT Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins
RL Genes Dev. 3:770-781 (1989).
RN [12]; RE0000662.
RX PUBMED: 2498163.
RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E.
RT Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction
RL Genes Dev. 3:304-313 (1989).
RN [13]; RE0000970.
RX PUBMED: 1900839.
RA Adunyah S. E., Unlap T. M., Wagner F., Kraft A. S.
RT Regulation of c-jun expression and AP-1 enhancer activity by granulocyte-macrophage colony-stimulating factor
RL J. Biol. Chem. 266:5670 (1991).
RN [14]; RE0001012.
RX PUBMED: 1847391.
RA Fink J. S., Verhave M., Walton K., Mandel G., Goodman R. H.
RT Cyclic AMP- and phorbol ester-induced transcriptional activation are mediated by the same enhancer element in the human vasoactive intestinal peptide gene
RL J. Biol. Chem. 266:3882-3887 (1991).
RN [15]; RE0001155.
RX PUBMED: 2536818.
RA Yamaguchi Y., Satake M., Ito Y.
RT Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene
RL J. Virol. 63:1040-1048 (1989).
RN [16]; RE0001453.
RX PUBMED: 2115122.
RA Gius D., Cao X., Rauscher III F. J., Cohen D. R., Curran T., Sukhatme V. P.
RT Transcriptional Activation and Repression by Fos Are Independent Functions: The C Terminus Represses Immediate-Early Gene Expression via CArG Elements
RL Mol. Cell. Biol. 10:4243-4255 (1990).
RN [17]; RE0001460.
RX PUBMED: 2501665.
RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R.
RT Expression of raf oncogenes activates the PEA1 transcription factor motif
RL Mol. Cell. Biol. 9:2247-2250 (1989).
RN [18]; RE0001462.
RX PUBMED: 2320002.
RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H.
RT A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain
RL Mol. Cell. Biol. 10:1347-1357 (1990).
RN [19]; RE0001581.
RX PUBMED: 1846672.
RA Kamata N., Jotte R. M., Holt J. T.
RT Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein
RL Mol. Cell. Biol. 11:765-772 (1991).
RN [20]; RE0001625.
RX PUBMED: 1901948.
RA Devary Y., Gottlieb R. A., Lau L. F., Karin M.
RT Rapid and preferential activation of the c-jun gene during the mammalian UV response
RL Mol. Cell. Biol. 11:2804-2811 (1991).
RN [21]; RE0001772.
RX PUBMED: 3347253.
RA Angel P., Allegretto E. A., Okino S. T., Hattori K., Boyle W. J., Hunter T., Karin M.
RT Oncogene jun encodes a sequence-specific trans-activator similar to AP-1
RL Nature 332:166-171 (1988).
RN [22]; RE0001940.
RX PUBMED: 2518690.
RA Angel P., Smeal T., Meek J., Karin M.
RT jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner
RL New Biol. 1:35-43 (1989).
RN [23]; RE0001941.
RX PUBMED: 1963081.
RA Yang-Yen H.-F., Chiu R., Karin M.
RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription
RL New Biol. 2:351-361 (1990).
RN [24]; RE0002170.
RX PUBMED: 1906606.
RA Buttice G., Quinones S., Kurkinen M.
RT The AP-1 site is required for basal expression but is not necessary for TPA-response of the human stromelysin gene
RL Nucleic Acids Res. 19:3723-3731 (1991).
RN [25]; RE0002299.
RX PUBMED: 2492109.
RA Sharma A., Bos T. J., Pekkala-Flagan A., Vogt P. K., Lee A. S.
RT Interaction of cellular factors related to the Jun oncoprotein with the promoter of a replication-dependent hamster histone H3.2 gene
RL Proc. Natl. Acad. Sci. USA 86:491-495 (1989).
RN [26]; RE0002382.
RX PUBMED: 2771941.
RA Mignotte V., Eleouet J. F., Raich N., Romeo P.-H.
RT Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene
RL Proc. Natl. Acad. Sci. USA 86:6548-6552 (1989).
RN [27]; RE0002407.
RX PUBMED: 3174663.
RA Saffen D. W., Cole A. J., Worley P. F., Christy B. A., Ryder K., Baraban J. M.
RT Convulsant-induced increase in transcription factor messenger RNAs in rat brain
RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988).
RN [28]; RE0002408.
RX PUBMED: 2453058.
RA Piette J., Hirai S.-I., Yaniv M.
RT Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts
RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988).
RN [29]; RE0002561.
RX PUBMED: 1827203.
RA Hai T., Curran T.
RT Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991).
RN [30]; RE0002566.
RX PUBMED: 1648728.
RA Schuele R., Rangarajan P., Yang N., Kliewer S., Ransone L. J., Bolado J., Verma I. M., Evans R. M.
RT Retinoic acid is a negative regulator of AP-1-responsive genes
RL Proc. Natl. Acad. Sci. USA 88:6092-6096 (1991).
RN [31]; RE0002591.
RX PUBMED: 2964084.
RA Franza jr B. R., Rauscher III F. J., Josephs S. F., Curran T.
RT The Fos-complex and Fos-related antigens recognize sequence elements that contain AP-2 binding sites
RL Science 239:1150-1153 (1988).
RN [32]; RE0002619.
RX PUBMED: 2494701.
RA Turner R., Tjian R.
RT Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers
RL Science 243:1689-1694 (1989).
RN [33]; RE0002620.
RX PUBMED: 2494702.
RA Gentz R., Rauscher III F. J., Abate C., Curan T.
RT Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains
RL Science 243:1695-1699 (1989).
RN [34]; RE0002630.
RX PUBMED: 2825349.
RA Bohmann D., Bos T. J., Admon A., Nishimura T., Vogt P. K., Tjian R.
RT Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
RL Science 238:1386-1392 (1987).
RN [35]; RE0002710.
RX PUBMED: 8211160.
RA Wagner S., Green M. R.
RT HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization
RL Science 262:395-399 (1993).
RN [36]; RE0002956.
RX PUBMED: 1328861.
RA Trejo J., Chambard J.-C., Karin M., Brown J. H.
RT Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: Differential effects of muscarinic and thrombin receptor activation
RL Mol. Cell. Biol. 12:4742- 4750 (1992).
RN [37]; RE0003141.
RX PUBMED: 3194415.
RA Hattori K., Angel P., Le Beau M.M., Karin M.
RT Structure and chromosomal localization of the functional intronless human jun protooncogene
RL Proc. Natl. Acad. Sci. USA 85:9148-9152 (1988).
RN [38]; RE0003225.
RX PUBMED: 1313772.
RA Li L., Chambard J. C., Karin M., Olson E. N.
RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression
RL Genes Dev. 6:676-689 (1992).
RN [39]; RE0004649.
RX PUBMED: 3130660.
RA Rauscher III F. J., Cohen D. R., Curran T., Bos T. J., Vogt P. K., Bohmann D., Tjian R., Franza jr B. R.
RT Fos-associated protein p39 is the product of the jun proto-oncogene
RL Science 240:1010-1016 (1988).
RN [40]; RE0004657.
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RT The cancer/testis antigen CAGE with oncogenic potential stimulates cell proliferation by up-regulating cyclins D1 and E in an AP-1- and E2F-dependent manner.
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RT EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo.
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RA Da Costa C. R., Villadiego J., Sancho R., Fontana X., Packham G., Nateri A. S., Behrens A.
RT Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis.
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RA Krysan K., Lou M. F.
RT Regulation of human thioltransferase (hTTase) gene by AP-1 transcription factor under oxidative stress.
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RA Loesch M., Zhi H. Y., Hou S. W., Qi X. M., Li R. S., Basir Z., Iftner T., Cuenda A., Chen G.
RT p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9.
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RA Johnson E., Seachrist D. D., DeLeon-Rodriguez C. M., Lozada K. L., Miedler J., Abdul-Karim F. W., Keri R. A.
RT HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42.
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RT Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.
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RA Yamagata K., Li X., Ikegaki S., Oneyama C., Okada M., Nishita M., Minami Y.
RT Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression.
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RT Transcription factor c-Jun activation represses mdr-1 gene expression.
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