TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00133 XX ID T00133 XX DT 15.10.1992 (created); ewi. DT 04.06.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA c-Jun XX SY AP1; c-Jun; JunA; p39; p39-jun. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G000219 JUN; HGNC: JUN. XX CL C0008; bZIP; XX SF structural properties have been investigated by CD and fluorescence spectroscopy [40]; SF 1H-NMR spectroscopy [42] [63]; SF 15N-NMR [46]; SF and co-crystallization of c-Jun-DNA complexes [68]; SF c-Jun homodimerizes through the leucine zipper motif [32]; SF at least three leucine residues and some additional residues of the zipper region are important for dimerization [11]; SF heterodimers with c-Fos are more stable than homodimers [11]; SF two zipper motifs associate in a parallel manner forming a coiled-coil structure [42]; SF zipper dimerization juxtaposes the basic regions to form a contiguous DNA-binding interface [32]; SF upon DNA-binding, the basic regions adopt alpha-helical conformation to form a long helix along with that of the zipper regions [68]; SF the heterodimer with c-Fos binds 25-fold more efficiently to DNA than the homodimer [3]; SF no specific orientation of the heterodimer upon binding to the TGAGTCA recognition sequence [68]; SF preferential binding of homo- and c-Fos-heterodimers to TREs, but some promiscuity for CREs has been found as well [1] [49]; SF the leucine zipper region interacts also with the Rel domain of RelA [69]; SF the bZP domain targets the second trans-activating domain of E2A proteins when repressing their activation potential [72]; SF the regulatory regions delta and epsilon may interact with other proteins [40] [41]; SF delta may play an essential role in the interaction of c-Jun with a protein kinase [58]; SF activation domain A1 is composed of a1 and epsilon [41]; SF activation domain A2 is enriched in acidic and proline residues and is embedded in a glutamine and proline rich environment [2] [71]; SF interaction with SMAD-3 T04096 and SMAD-4 T04292 through the SMAD-binding site [77]; XX CP ubiquitous; BL-13 and HT1376 cells [85]; EGF treated JEG-3 cells [133]; Highly expressed in 184B5/HER-2 breast cancer cells than in 184B5 cells [105]; MCF-7 + E2 [106]. CN Macrophages, U937 [134]. XX FF Up-regulated by salvicine, a topoisomerase II inhibitor [132]; FF activator, in particular of genes required for DNA synthesis and cell proliferation [55]; FF in some case may activate gene transcription without direct binding to DNA, through protein-protein interactions with Sp1 [82]; FF weaker trans-activator than v-Jun due to regulatory domain delta [2] [40]; FF direct interactions with coactivator CBP/p300 [79]; FF inhibits myogenesis by direct interaction with MyoD [38]; FF exhibits transforming activity which is enhanced by c-Fos, but inhibited by JunB [54]; FF inducible by UV and H2O2 through a Raf-1 dependent pathway [60] [61]; FF activity is redox-regulated via oxidation of Cys-269 which involves Ref-1 as redox component [52]; FF AP-1 activity declines during cell ageing, possibly due to loss of reducing potential [55]; FF mediates gene activation synergistically with c-Jun in response to FGF / Ras and cAMP, but only the former enhances c-Jun protein levels [73]; FF target of a signalling cascade starting with Ha-Ras and resulting in c-Jun phosphorylation on Ser-63 and Ser-73 by JNK or ERK protein kinases [50] [51] [53] [59] [62] [64]; FF this phosphorylation is stimulated by phorbol esters and enhances trans-activation by c-Jun [48] [50] [58]; FF phosphorylation of Thr-231, -239, Ser-243 and -249 by GSK3, DNA-PK, CK II, or others inhibits DNA-binding [44] [57] [4]; FF this inhibitory phosphorylation is rapidly reversed after activation of PKC and subsequent modification of the N-terminal phosphorylation sites [4]; FF c-Jun inhibits GR; FF DNA-binding is inhibited by RAR, possibly by direct interaction through the RAR-DNA binding domain; FF it is also repressed by T3R-alpha; FF inhibition by RAR/T3R is abrogated by v-ErbA; FF enhanced mRNA levels after thrombin treatment, 2 maxima after 0.5 and 12h [36]; FF significant enhancement of dimerization by Tax; FF adenoviral E1A interacts with c-Jun in particular when present in a heterodimer with CRE-BP1/ATF-2 which subsequently induces the c-jun gene through its distal AP-1 site [43]; FF HBV trans-activator pX influence phosphorylation of the DNA-binding domain and induces DNA-binding of the c-Fos/c-Jun heterodimer [47]; XX IN T00015 AFP1; human, Homo sapiens. IN T29723 alpha-actinin-4; human, Homo sapiens. IN T06598 AML-1; mouse, Mus musculus. IN T08443 AML3; mouse, Mus musculus. IN T00167 ATF-2-isoform1; human, Homo sapiens. IN T01017 ATF-2-isoform2; mouse, Mus musculus. IN T01382 ATF-2; rat, Rattus norvegicus. IN T10136 ATF-2; human, Homo sapiens. IN T01313 ATF-3-isoform1; human, Homo sapiens. IN T01095 ATF-3; rat, Rattus norvegicus. IN T01303 ATF-4; human, Homo sapiens. IN T00051 ATF; human, Homo sapiens. IN T06579 batf3; rat, Rattus norvegicus. IN T04074 brca1; human, Homo sapiens. IN T00122 c-Fos; mouse, Mus musculus. IN T00123 c-Fos; human, Homo sapiens. IN T00124 c-Fos; rat, Rattus norvegicus. IN T00125 c-Fos; chick, Gallus gallus. IN T00133 c-Jun; human, Homo sapiens. IN T00108 C/EBPalpha-isoform1; rat, Rattus norvegicus. IN T00581 C/EBPbeta; human, Homo sapiens. IN T02214 CBP-isoform1; human, Homo sapiens. IN T18378 CBP; human, Homo sapiens. IN T28745 chd2; human, Homo sapiens. IN T08562 CREB1; human, Homo sapiens. IN T01308 CREBPA; human, Homo sapiens. IN T02198 deltaFosB; mouse, Mus musculus. IN T00967 E1A 12S protein; adenovirus. IN T00209 E1A 13S protein; adenovirus type 2. IN T01376 E7; HPV-16, human papilloma virus type 16. IN T01113 Elf-1; human, Homo sapiens. IN T00261 ER-alpha; human, Homo sapiens. IN T05220 Evi-1; human, Homo sapiens. IN T22597 FLIL; human, Homo sapiens. IN T00291 FosB; mouse, Mus musculus. IN T08993 FOSB; human, Homo sapiens. IN T00292 Fra-1; mouse, Mus musculus. IN T01208 Fra-1; rat, Rattus norvegicus. IN T30386 Fra-1; Mammalia. IN T01990 Fra-2; chick, Gallus gallus. IN T00337 GR-alpha; human, Homo sapiens. IN T01920 GR-beta; human, Homo sapiens. IN T00333 GR; rat, Rattus norvegicus. IN T00334 GR; chick, Gallus gallus. IN T00335 GR; mouse, Mus musculus. IN T00336 GR; cat, Felis silvestris catus. IN T01610 HIF-1alpha; human, Homo sapiens. IN T06578 jdp2; rat, Rattus norvegicus. IN T00441 KRC; human, Homo sapiens. IN T04870 MafG; human, Homo sapiens. IN T19074 MLL3; human, Homo sapiens. IN T01082 NRL; human, Homo sapiens. IN T01427 p300; human, Homo sapiens. IN T06377 PML; human, Homo sapiens. IN T10799 PSIP1; human, Homo sapiens. IN T04878 Ref-1; human, Homo sapiens. IN T00594 RelA-p65-isoform1; human, Homo sapiens. IN T30231 SIRT1-isoform1; human, Homo sapiens. IN T00759 Sp1; human, Homo sapiens. IN T04759 STAT1; human, Homo sapiens. IN T01493 STAT3; human, Homo sapiens. IN T14458 STAT3; Mammalia. IN T17428 TFIIB; Mammalia. IN T24918 TST1; human, Homo sapiens. IN T00888 v-Fos; FBR MuLV, FBR murine osteosarcoma virus. IN T08660 YY1; human, Homo sapiens. IN T04355 zhx1; human, Homo sapiens. XX MX M00172 V$AP1FJ_Q2. MX M00517 V$AP1_01. MX M02280 V$AP1_02. MX M00924 V$AP1_Q2_01. MX M00926 V$AP1_Q4_01. MX M00925 V$AP1_Q6_01. MX M03541 V$CJUN_Q6. MX M00041 V$CREBP1CJUN_01. MX M04879 V$JUN_02. MX M07101 V$JUN_03. MX M07102 V$JUN_04. MX M08776 V$JUN_05. XX BS R02963. BS R03082. BS R03533. BS R20747. BS R25003. BS R23156. BS R24028. BS R25291. BS R29956. BS R00199. BS R64855. BS R66333. BS R63058. BS R60543. BS R57580. BS R73456. BS R70646. BS R70685. BS R70687. BS R20759. BS R11553. BS R15123. BS R40927. BS R71679. BS R71680. BS R72663. BS R72666. BS R72667. BS R72668. BS R02420. BS R62972. BS R62973. BS R21775. BS R62338. BS R26587. BS R30618. BS R62608. BS R08102. BS R25008. BS R25298. BS R65615. BS R27992. BS R21383. BS R67452. BS R67453. BS R67454. BS R67346. BS R67348. BS R68064. BS R32256. BS R32257. BS R62977. BS R62914. BS R34933. BS R30365. BS R30605. BS R28264. BS R59117. BS R59118. BS R64931. BS R64932. BS R64934. BS R64935. BS R24143. BS R41717. BS R61970. BS R61972. BS R26710. BS R65485. BS R36308. BS R04127. BS R61832. BS R26909. BS R20982. BS R29738. BS R25208. BS R14540. BS R67078. BS R60801. BS R55747. BS R36614. BS R32275. BS R14730. BS R36330. BS R20615. BS R19568. BS R19569. BS R23150. BS R39947. BS R71318. BS R28518. BS R32843. BS R39854. BS R66419. BS R26802. BS R31706. BS R31708. BS R41737. BS R28548. BS R29722. BS R73759. BS R25290. BS R35430. BS R29092. BS R29093. BS R34716. BS R03522. BS R25249. BS R60811. BS R14544. BS R29953. BS R73960. BS R25018. BS R30031. BS R26674. BS R74081. BS R39833. BS R31024. BS R66292. BS R72604. BS R31611. BS R14725. BS R26758. BS R08483. BS R09953. BS R14786. BS R64355. BS R38717. BS R42519. BS R42520. BS R62790. BS R62791. BS R59991. BS R64459. BS R64460. BS R59836. BS R67678. BS R37694. BS R26793. BS R26797. BS R00235. BS R09882. BS R24701. BS R25170. BS R26528. BS R28553. BS R34213. BS R55780. BS R55786. BS R55789. BS R25055. BS R34900. BS R73091. BS R15813. BS R15814. BS R40491. BS R40652. BS R01037. BS R26884. BS R40078. BS R40087. BS R37737. BS R18404. BS R32816. BS R67583. BS R29634. BS R22860. BS R35944. BS R42041. BS R34120. BS R11383. BS R38720. BS R72631. BS R42031. BS R39872. BS R01258. BS R55848. BS R36611. BS R08493. BS R08494. BS R57523. BS R72678. BS R24999. BS R67505. BS R11552. BS R67201. BS R27962. BS R32291. BS R64470. BS R34853. BS R00007. BS R37644. BS R40017. BS R63471. BS R29975. BS R22636. BS R62946. BS R67340. BS R64814. BS R31056. BS R65836. BS R19623. BS R19624. BS R21760. BS R21763. BS R40648. BS R21747. BS R64837. BS R63071. BS R29828. BS R03186. BS R24500. BS R64839. BS R60236. BS R36401. BS R31558. BS R40563. BS R33800. BS R60945. BS R01564. BS R01559. BS R37726. BS R31379. BS R70819. BS R70820. BS R65079. BS R02454. BS R03386. BS R31616. BS R73704. BS R14160. BS R34548. BS R01285. BS R03532. BS R30931. BS R26861. BS R39337. BS R26504. BS R18127. BS R18128. BS R18130. BS R01358. BS R01383. BS R01384. BS R01394. BS R01412. XX DR TRANSPATH: MO000019469. DR TRANSCOMPEL: C00191. DR TRANSCOMPEL: C00195. DR TRANSCOMPEL: C00318. DR TRANSCOMPEL: C00347. DR TRANSCOMPEL: C00381. DR TRANSCOMPEL: C00397. DR TRANSCOMPEL: C00416. DR TRANSCOMPEL: C00420. DR TRANSCOMPEL: C00421. DR TRANSCOMPEL: C00440. DR TRANSCOMPEL: C00495. DR UniProtKB: P05412; DR PDB: 1FOS. DR PDB: 1JUN. XX RN [1]; RE0000050. RX PUBMED: 3034432. RA Angel P., Imagawa M., Chiu R., Stein B., Imbra R. J., Rahmsdorf H. J., Jonat C., Herrlich P., Karin M. RT Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor RL Cell 49:729-739 (1987). RN [2]; RE0000124. RX PUBMED: 2510934. RA Bohmann D., Tjian R. RT Biochemical analysis of transcriptional activation by Jun: Differential activity of c- and v-Jun RL Cell 59:709-717 (1989). RN [3]; RE0000144. RX PUBMED: 3142692. RA Halazonetis T. D., Georgopoulos K., Greenberg M. E., Leder P. RT c-jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities RL Cell 55:917-924 (1988). RN [4]; RE0000157. RX PUBMED: 1846781. RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [5]; RE0000158. RX PUBMED: 1900458. RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [6]; RE0000166. RX PUBMED: 2124518. RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [7]; RE0000247. RX PUBMED: 2169353. RA Schuele R., Rangarajan P., Kliewer S., Ransone L. J., Bolado J., Yang N., Verma I. M., Evans R. M. RT Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor RL Cell 62:1217-1226 (1990). RN [8]; RE0000248. RX PUBMED: 2169352. RA Yang-Yen H.-F., Chambard J.-C., Sun Y.-L., Smeal T., Schmidt T. J., Drouin J., Karin M. RT Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction RL Cell 62:1205-1215 (1990). RN [9]; RE0000269. RX PUBMED: 1682056. RA Desbois C., Aubert D., Legrand C., Pain B., Samarut J. RT A novel mechanism of action for v-erbA: abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors RL Cell 67:731-740 (1991). RN [10]; RE0000521. RX PUBMED: 1714380. RA de Groot R. P., Karperien M., Pals C., Kruijer W. RT Characterization of the mouse junD promoter - high basal level activity due to an octamer motif RL EMBO J. 10:2523-2532 (1991). RN [11]; RE0000636. RX PUBMED: 2501150. RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M. RT Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins RL Genes Dev. 3:770-781 (1989). RN [12]; RE0000662. RX PUBMED: 2498163. RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [13]; RE0000970. RX PUBMED: 1900839. RA Adunyah S. E., Unlap T. M., Wagner F., Kraft A. S. RT Regulation of c-jun expression and AP-1 enhancer activity by granulocyte-macrophage colony-stimulating factor RL J. Biol. Chem. 266:5670 (1991). RN [14]; RE0001012. RX PUBMED: 1847391. RA Fink J. S., Verhave M., Walton K., Mandel G., Goodman R. H. RT Cyclic AMP- and phorbol ester-induced transcriptional activation are mediated by the same enhancer element in the human vasoactive intestinal peptide gene RL J. Biol. Chem. 266:3882-3887 (1991). RN [15]; RE0001155. RX PUBMED: 2536818. RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [16]; RE0001453. RX PUBMED: 2115122. RA Gius D., Cao X., Rauscher III F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are Independent Functions: The C Terminus Represses Immediate-Early Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). RN [17]; RE0001460. RX PUBMED: 2501665. RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [18]; RE0001462. RX PUBMED: 2320002. RA Kara C. J., Liou H.-C., Ivashkiv L. B., Glimcher L. H. RT A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain RL Mol. Cell. Biol. 10:1347-1357 (1990). RN [19]; RE0001581. RX PUBMED: 1846672. RA Kamata N., Jotte R. M., Holt J. T. RT Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein RL Mol. Cell. Biol. 11:765-772 (1991). RN [20]; RE0001625. RX PUBMED: 1901948. RA Devary Y., Gottlieb R. A., Lau L. F., Karin M. RT Rapid and preferential activation of the c-jun gene during the mammalian UV response RL Mol. Cell. Biol. 11:2804-2811 (1991). RN [21]; RE0001772. RX PUBMED: 3347253. RA Angel P., Allegretto E. A., Okino S. T., Hattori K., Boyle W. J., Hunter T., Karin M. RT Oncogene jun encodes a sequence-specific trans-activator similar to AP-1 RL Nature 332:166-171 (1988). RN [22]; RE0001940. RX PUBMED: 2518690. RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner RL New Biol. 1:35-43 (1989). RN [23]; RE0001941. RX PUBMED: 1963081. RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription RL New Biol. 2:351-361 (1990). RN [24]; RE0002170. RX PUBMED: 1906606. RA Buttice G., Quinones S., Kurkinen M. RT The AP-1 site is required for basal expression but is not necessary for TPA-response of the human stromelysin gene RL Nucleic Acids Res. 19:3723-3731 (1991). RN [25]; RE0002299. RX PUBMED: 2492109. RA Sharma A., Bos T. J., Pekkala-Flagan A., Vogt P. K., Lee A. S. RT Interaction of cellular factors related to the Jun oncoprotein with the promoter of a replication-dependent hamster histone H3.2 gene RL Proc. Natl. Acad. Sci. USA 86:491-495 (1989). RN [26]; RE0002382. RX PUBMED: 2771941. RA Mignotte V., Eleouet J. F., Raich N., Romeo P.-H. RT Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene RL Proc. Natl. Acad. Sci. USA 86:6548-6552 (1989). RN [27]; RE0002407. RX PUBMED: 3174663. RA Saffen D. W., Cole A. J., Worley P. F., Christy B. A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [28]; RE0002408. RX PUBMED: 2453058. RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [29]; RE0002561. RX PUBMED: 1827203. RA Hai T., Curran T. RT Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991). RN [30]; RE0002566. RX PUBMED: 1648728. RA Schuele R., Rangarajan P., Yang N., Kliewer S., Ransone L. J., Bolado J., Verma I. M., Evans R. M. RT Retinoic acid is a negative regulator of AP-1-responsive genes RL Proc. Natl. Acad. Sci. USA 88:6092-6096 (1991). RN [31]; RE0002591. RX PUBMED: 2964084. RA Franza jr B. R., Rauscher III F. J., Josephs S. F., Curran T. RT The Fos-complex and Fos-related antigens recognize sequence elements that contain AP-2 binding sites RL Science 239:1150-1153 (1988). RN [32]; RE0002619. RX PUBMED: 2494701. RA Turner R., Tjian R. RT Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers RL Science 243:1689-1694 (1989). RN [33]; RE0002620. RX PUBMED: 2494702. RA Gentz R., Rauscher III F. J., Abate C., Curan T. RT Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains RL Science 243:1695-1699 (1989). RN [34]; RE0002630. RX PUBMED: 2825349. RA Bohmann D., Bos T. J., Admon A., Nishimura T., Vogt P. K., Tjian R. RT Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1 RL Science 238:1386-1392 (1987). RN [35]; RE0002710. RX PUBMED: 8211160. RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [36]; RE0002956. RX PUBMED: 1328861. RA Trejo J., Chambard J.-C., Karin M., Brown J. H. RT Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: Differential effects of muscarinic and thrombin receptor activation RL Mol. Cell. Biol. 12:4742- 4750 (1992). RN [37]; RE0003141. RX PUBMED: 3194415. RA Hattori K., Angel P., Le Beau M.M., Karin M. RT Structure and chromosomal localization of the functional intronless human jun protooncogene RL Proc. Natl. Acad. Sci. USA 85:9148-9152 (1988). RN [38]; RE0003225. RX PUBMED: 1313772. RA Li L., Chambard J. C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [39]; RE0004649. RX PUBMED: 3130660. RA Rauscher III F. J., Cohen D. R., Curran T., Bos T. J., Vogt P. K., Bohmann D., Tjian R., Franza jr B. R. RT Fos-associated protein p39 is the product of the jun proto-oncogene RL Science 240:1010-1016 (1988). RN [40]; RE0004657. RX PUBMED: 2121368. RA Baichwal V. R., Tjian R. RT Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain delta: Differences between v- and c-Jun RL Cell 63:815-825 (1990). RN [41]; RE0004661. RX PUBMED: 1644291. RA Baichwal V. R., Park A., Tjian R. RT The cell-type-specific activator region of c-Jun juxtaposes constitutive and negatively regulated domains RL Genes Dev. 6:1493-1502 (1992). RN [42]; RE0004664. RX PUBMED: 8513791. RA Junius F. K., Weiss A. S., King G. F. RT The solution stucture of the leucine zipper motif of the Jun oncoprotein homodimer RL Eur. J. Biochem. 214:415-424 (1993). RN [43]; RE0004665. RX PUBMED: 8382609. RA van Dam H., Duyndam M., Rottier R., Bosch A., de Vries-Smits L., Herrlich P., Zantema A., Angel P., van der Eb A. J. RT Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amin acid adenovirus E1A protein RL EMBO J. 12:479-487 (1993). RN [44]; RE0004667. RX PUBMED: 8464713. RA Bannister A. J., Gottlieb T. M., Kouzarides T., Jackson S. P. RT c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif RL Nucleic Acids Res. 21:1289-1295 (1993). RN [45]; RE0004671. RX PUBMED: 8087846. RA Treier M., Staszewski L. M., Bohmann D. RT Ubiquitin-dependent c-Jun degradattion in vivo is mediated by the delta domain RL Cell 78:787-798 (1994). RN [46]; RE0004672. RX PUBMED: 8112339. RA Riley L. G., Junius F. K., Swanton M. K., Vesper N. A., Williams N. K., King G. F., Weiss A. S. RT Cloning, expression, and spectroscopic studies of the Jun leucine zipper domain RL Eur. J. Biochem. 219:877-889 (1994). RN [47]; RE0004673. RX PUBMED: 7507209. RA Natoli G., Avantaggiati M. L., Chirillo P., Costanzo A., Artini M., Balsano C., Levrero M. RT Induction of the DNA-binding activity of c-Jun/c-Fos heterodimers by the hepatitis B virus transactivator pX RL Mol. Cell. Biol. 14:989-998 (1994). RN [48]; RE0004674. RX PUBMED: 7935387. RA Minden A., Lin A., Smeal T., Derijard B., Cobb M., Davis R., Karin M. RT c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases RL Mol. Cell. Biol. 14:6683-6688 (1994). RN [49]; RE0004677. RX PUBMED: 2107494. RA Sassone-Corsi P., Ransone L. J., Verma I. M. RT Cross-talk in signal transduction: TPA-inducible factor jun/AP-1 activates cAMP-responsive enhancer elements RL Oncogene 5:427-431 (1990). RN [50]; RE0004678. RX PUBMED: 1903181. RA Binetruy B., Smeal T., Karin M. RT Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain RL Nature 351:122-127 (1991). RN [51]; RE0004680. RX PUBMED: 1922387. RA Pulverer B. J., Kyriakis J. M., Avruch J., Nikolakaki E., Woodgett J. R. RT Phosphorylation of c-jun mediated by MAP kinases RL Nature 353:670-674 (1991). RN [52]; RE0004682. RX PUBMED: 1537340. RA Xanthoudakis S., Curran T. 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