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AC T08443
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ID T08443
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DT 20.01.2006 (created); res.
DT 24.07.2015 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA AML3
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SY AML3; CBF-alpha 1; CBFA1; PEBP2alpha1; PEBP2alphaA; RUNX2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005054 Runx2.
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CL C0029; runt; 6.4.1.0.1.
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CP odontoblasts, preamloblast, pulp cells, and osteoblast cells within alveolar bone (E16); high in ameloblast and osteoblast, low in odontoblast and pulp cells in developing alveolar bones (postnatal day 1); very high in osteoblast and ameloblast, very low in odontoblast and pulp cells in developing alveolar bones (postnatal day 3) [14].
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FF PKCdelta mediates the FGF2-induced AML3 expression [12];
FF Binds to Bsp promoter and enhances transcription in Osteoblast specific cells [9];
FF FGF2 increases the DNA-binding activity and transactivation activity of the AML3 at the site R19732 [12];
FF Treatment of cells with recombinant human FGF2 can increase the AML3 expression in MC3T3-E1 (type II isoform) and C2C12 cells (type I and type II isoforms), and this FGF2-mediated up-regulation is inhibited by treatment of cells with PKC inhibitors (calphostin C and GF109203X) [12];
FF Osteoblast specific binding to Collagen alpha 1(I)G000469 promoter. [10];
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IN T15601 AR; Mammalia.
IN T08444 ATF-4; mouse, Mus musculus.
IN T10346 c-Fos; Mammalia.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T01114 C/EBPdelta; mouse, Mus musculus.
IN T03989 Dlx-5; mouse, Mus musculus.
IN T10446 GR; Mammalia.
IN T03235 Grg-5; mouse, Mus musculus.
IN T01648 HES-1; rat, Rattus norvegicus.
IN T09895 HES-1; human, Homo sapiens.
IN T08628 POU2F1; Mammalia.
IN T00722 pRb; human, Homo sapiens.
IN T25008 pRb; Mammalia.
IN T22859 TAZ; mouse, Mus musculus.
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MX M07276 V$AML3_Q3.
MX M01856 V$AML3_Q6.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00731 V$OSF2_Q6.
MX M00984 V$PEBP_Q6.
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BS R56072.
BS R24722.
BS R41594.
BS R36138.
BS R66609.
BS R19732.
BS R19740.
BS R67122.
BS R67124.
BS R41498.
BS R19708.
BS R20430.
BS R20431.
BS R68935.
BS R36246.
BS R59095.
BS R19678.
BS R19679.
BS R29447.
BS R33956.
BS R33960.
BS R33959.
BS R41255.
BS R41253.
BS R57645.
BS R67125.
BS R67128.
BS R67121.
BS R30496.
BS R64552.
BS R29498.
BS R18139.
BS R34845.
BS R24508.
BS R24509.
BS R36393.
BS R36394.
BS R36395.
BS R60872.
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DR TRANSPATH: MO000057862.
DR TRANSCOMPEL: C00471.
DR TRANSCOMPEL: C00533.
DR TRANSCOMPEL: C00608.
DR UniProtKB: Q08775; RUNX2_MOUSE.
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RN [1]; RE0023220.
RX PUBMED: 11274169.
RA Hess J., Porte D., Munz C., Angel P.
RT AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.
RL J. Biol. Chem. 276:20029-20038 (2001).
RN [2]; RE0035805.
RX PUBMED: 15183720.
RA Wang W., Wang Y. G., Reginato A. M., Glotzer D. J., Fukai N., Plotkina S., Karsenty G., Olsen B. R.
RT Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice.
RL Dev. Biol. 270:364-381 (2004).
RN [3]; RE0035828.
RX PUBMED: 10521447.
RA Ning Y. M., Robins D. M.
RT AML3/CBFalpha1 is required for androgen-specific activation of the enhancer of the mouse sex-limited protein (Slp) gene.
RL J. Biol. Chem. 274:30624-30630 (1999).
RN [4]; RE0035837.
RX PUBMED: 16000305.
RA Xiao G., Jiang D., Ge C., Zhao Z., Lai Y., Boules H., Phimphilai M., Yang X., Karsenty G., Franceschi R. T.
RT Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression.
RL J. Biol. Chem. 280:30689-30696 (2005).
RN [5]; RE0035901.
RX PUBMED: 11683913.
RA Shirakabe K., Terasawa K., Miyama K., Shibuya H., Nishida E.
RT Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5.
RL Genes Cells 6:851-856 (2001).
RN [6]; RE0035927.
RX PUBMED: 15798204.
RA Inman C. K., Li N., Shore P.
RT Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein.
RL Mol. Cell. Biol. 25:3182-3193 (2005).
RN [7]; RE0038752.
RX PUBMED: 12529404.
RA Cui C. B., Cooper L. F., Yang X., Karsenty G., Aukhil I.
RT Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ
RL Mol. Cell. Biol. 23:1004-13 (2003).
RN [8]; RE0048225.
RX PUBMED: 15123671.
RA Liu H., Holm M., Xie X. Q., Wolf-Watz M., Grundstrom T.
RT AML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation.
RL J. Biol. Chem. 279:29398-29408 (2004).
RN [9]; RE0048544.
RX PUBMED: 16000302.
RA Roca H., Phimphilai M., Gopalakrishnan R., Xiao G., Franceschi R. T.
RT Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene.
RL J. Biol. Chem. 280:30845-30855 (2005).
RN [10]; RE0048552.
RX PUBMED: 11106645.
RA Kern B., Shen J., Starbuck M., Karsenty G.
RT Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes.
RL J. Biol. Chem. 276:7101-7107 (2001).
RN [11]; RE0048954.
RX PUBMED: 16753023.
RA Lee J. S., Thomas D. M., Gutierrez G., Carty S. A., Yanagawa S., Hinds P. W.
RT HES1 cooperates with pRb to activate RUNX2-dependent transcription.
RL J. Bone Miner. Res. 21:921-933 (2006).
RN [12]; RE0048973.
RX PUBMED: 12403780.
RA Kim H. J., Kim J. H., Bae S. C., Choi J. Y., Kim H. J., Ryoo H. M.
RT The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2.
RL J. Biol. Chem. 278:319-326 (2003).
RN [13]; RE0055016.
RX PUBMED: 18430783.
RA Sakamoto K., Tamamura Y., Katsube K., Yamaguchi A.
RT Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells.
RL J. Cell Sci. 121:1613-1623 (2008).
RN [14]; RE0049123.
RX PUBMED: 15611122.
RA Kurihara I., Shibata H., Kobayashi S., Suda N., Ikeda Y., Yokota K., Murai A., Saito I., Rainey W. E., Saruta T.
RT Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.
RL J. Biol. Chem. 280:6721-6730 (2005).
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