TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T08443 XX ID T08443 XX DT 20.01.2006 (created); res. DT 24.07.2015 (updated); jtr. CO Copyright (C), QIAGEN. XX FA AML3 XX SY AML3; CBF-alpha 1; CBFA1; PEBP2alpha1; PEBP2alphaA; RUNX2. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005054 Runx2. XX CL C0029; runt; XX CP odontoblasts, preamloblast, pulp cells, and osteoblast cells within alveolar bone (E16); high in ameloblast and osteoblast, low in odontoblast and pulp cells in developing alveolar bones (postnatal day 1); very high in osteoblast and ameloblast, very low in odontoblast and pulp cells in developing alveolar bones (postnatal day 3) [14]. XX FF PKCdelta mediates the FGF2-induced AML3 expression [12]; FF Binds to Bsp promoter and enhances transcription in Osteoblast specific cells [9]; FF FGF2 increases the DNA-binding activity and transactivation activity of the AML3 at the site R19732 [12]; FF Treatment of cells with recombinant human FGF2 can increase the AML3 expression in MC3T3-E1 (type II isoform) and C2C12 cells (type I and type II isoforms), and this FGF2-mediated up-regulation is inhibited by treatment of cells with PKC inhibitors (calphostin C and GF109203X) [12]; FF Osteoblast specific binding to Collagen alpha 1(I)G000469 promoter. [10]; XX IN T15601 AR; Mammalia. IN T08444 ATF-4; mouse, Mus musculus. IN T10346 c-Fos; Mammalia. IN T00132 c-Jun; rat, Rattus norvegicus. IN T00133 c-Jun; human, Homo sapiens. IN T01114 C/EBPdelta; mouse, Mus musculus. IN T03989 Dlx-5; mouse, Mus musculus. IN T10446 GR; Mammalia. IN T03235 Grg-5; mouse, Mus musculus. IN T01648 HES-1; rat, Rattus norvegicus. IN T09895 HES-1; human, Homo sapiens. IN T08628 POU2F1; Mammalia. IN T00722 pRb; human, Homo sapiens. IN T25008 pRb; Mammalia. IN T22859 TAZ; mouse, Mus musculus. XX MX M07276 V$AML3_Q3. MX M01856 V$AML3_Q6. MX M08866 V$AML_Q4. MX M00769 V$AML_Q6. MX M00731 V$OSF2_Q6. MX M00984 V$PEBP_Q6. XX BS R56072. BS R24722. BS R41594. BS R36138. BS R66609. BS R19732. BS R19740. BS R67122. BS R67124. BS R41498. BS R19708. BS R20430. BS R20431. BS R68935. BS R36246. BS R59095. BS R19678. BS R19679. BS R29447. BS R33956. BS R33960. BS R33959. BS R41255. BS R41253. BS R57645. BS R67125. BS R67128. BS R67121. BS R30496. BS R64552. BS R29498. BS R18139. BS R34845. BS R24508. BS R24509. BS R36393. BS R36394. BS R36395. BS R60872. XX DR TRANSPATH: MO000057862. DR TRANSCOMPEL: C00471. DR TRANSCOMPEL: C00533. DR TRANSCOMPEL: C00608. DR UniProtKB: Q08775; RUNX2_MOUSE. XX RN [1]; RE0023220. RX PUBMED: 11274169. RA Hess J., Porte D., Munz C., Angel P. RT AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. RL J. Biol. Chem. 276:20029-20038 (2001). RN [2]; RE0035805. RX PUBMED: 15183720. RA Wang W., Wang Y. G., Reginato A. M., Glotzer D. J., Fukai N., Plotkina S., Karsenty G., Olsen B. R. RT Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice. RL Dev. Biol. 270:364-381 (2004). RN [3]; RE0035828. RX PUBMED: 10521447. RA Ning Y. M., Robins D. M. RT AML3/CBFalpha1 is required for androgen-specific activation of the enhancer of the mouse sex-limited protein (Slp) gene. RL J. Biol. Chem. 274:30624-30630 (1999). RN [4]; RE0035837. RX PUBMED: 16000305. RA Xiao G., Jiang D., Ge C., Zhao Z., Lai Y., Boules H., Phimphilai M., Yang X., Karsenty G., Franceschi R. T. RT Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. RL J. Biol. Chem. 280:30689-30696 (2005). RN [5]; RE0035901. RX PUBMED: 11683913. RA Shirakabe K., Terasawa K., Miyama K., Shibuya H., Nishida E. RT Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5. RL Genes Cells 6:851-856 (2001). RN [6]; RE0035927. RX PUBMED: 15798204. RA Inman C. K., Li N., Shore P. RT Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein. RL Mol. Cell. Biol. 25:3182-3193 (2005). RN [7]; RE0038752. RX PUBMED: 12529404. RA Cui C. B., Cooper L. F., Yang X., Karsenty G., Aukhil I. RT Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ RL Mol. Cell. Biol. 23:1004-13 (2003). RN [8]; RE0048225. RX PUBMED: 15123671. RA Liu H., Holm M., Xie X. Q., Wolf-Watz M., Grundstrom T. RT AML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation. RL J. Biol. Chem. 279:29398-29408 (2004). RN [9]; RE0048544. RX PUBMED: 16000302. RA Roca H., Phimphilai M., Gopalakrishnan R., Xiao G., Franceschi R. T. RT Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. RL J. Biol. Chem. 280:30845-30855 (2005). RN [10]; RE0048552. RX PUBMED: 11106645. RA Kern B., Shen J., Starbuck M., Karsenty G. RT Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes. RL J. Biol. Chem. 276:7101-7107 (2001). RN [11]; RE0048954. RX PUBMED: 16753023. RA Lee J. S., Thomas D. M., Gutierrez G., Carty S. A., Yanagawa S., Hinds P. W. RT HES1 cooperates with pRb to activate RUNX2-dependent transcription. RL J. Bone Miner. Res. 21:921-933 (2006). RN [12]; RE0048973. RX PUBMED: 12403780. RA Kim H. J., Kim J. H., Bae S. C., Choi J. Y., Kim H. J., Ryoo H. M. RT The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. RL J. Biol. Chem. 278:319-326 (2003). RN [13]; RE0055016. RX PUBMED: 18430783. RA Sakamoto K., Tamamura Y., Katsube K., Yamaguchi A. RT Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells. RL J. Cell Sci. 121:1613-1623 (2008). RN [14]; RE0049123. RX PUBMED: 15611122. RA Kurihara I., Shibata H., Kobayashi S., Suda N., Ikeda Y., Yokota K., Murai A., Saito I., Rainey W. E., Saruta T. RT Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription. RL J. Biol. Chem. 280:6721-6730 (2005). XX //