AC T22859
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ID T22859
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DT 13.02.2007 (created); sou.
DT 23.12.2013 (updated); prb.
CO Copyright (C), QIAGEN.
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FA TAZ
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SY 2310058J06Rik; 2610021I22Rik; C78399; TAZ; transcriptional co-activator with PDZ-binding motif; Transcriptional coactivator with PDZ-binding motif; WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; WWTR1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G042754 Wwtr1.
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SF The WW domain is required for Runx2 (/AML3/PEBP2alphaA1) interaction and TAZ-mediated stimulation of Runx2-driven gene transcription [1];
SF The WW domain of TAZ is required for PPAR-gamma interaction and TAZ-mediated repression of PPAR-gamma driven gene expression [1];
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FF endogenous regulator of osteoblast differentiation (co-activation of Runx2-dependent gene transcription) [1];
FF transcriptional repressor of PPAR-gamma-induced gene expression and an endogenous inhibitor of adipocyte differentiation [1];
FF bone marrow-derived MSCs depleted of TAZ show decreased osteogenesis and increased adipogenesis [1];
FF TAZ functions as a molecular rheostat that modulates mesenchymal stem cell (MSC) differentiation (fine-tune the balance between osteoblast and adipocyte development) [1];
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IN T01062 AML3; mouse, Mus musculus.
IN T08443 AML3; mouse, Mus musculus.
IN T10408 NFAT5; mouse, Mus musculus.
IN T09162 Pax-3; mouse, Mus musculus.
IN T05347 PPARgamma; mouse, Mus musculus.
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DR TRANSPATH: MO000098990.
DR UniProtKB: Q9EPK5; WWTR1_MOUSE.
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RN [1]; RE0035398.
RX PUBMED: 16099986.
RA Hong J. H., Hwang E. S., McManus M. T., Amsterdam A., Tian Y., Kalmukova R., Mueller E., Benjamin T., Spiegelman B. M., Sharp P. A., Hopkins N., Yaffe M. B.
RT TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
RL Science 309:1074-1078 (2005).
RN [2]; RE0038752.
RX PUBMED: 12529404.
RA Cui C. B., Cooper L. F., Yang X., Karsenty G., Aukhil I.
RT Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ
RL Mol. Cell. Biol. 23:1004-13 (2003).
RN [3]; RE0053016.
RX PUBMED: 16300735.
RA Murakami M., Tominaga J., Makita R., Uchijima Y., Kurihara Y., Nakagawa O., Asano T., Kurihara H.
RT Transcriptional activity of Pax3 is co-activated by TAZ.
RL Biochem. Biophys. Res. Commun. 339:533-539 (2006).
RN [4]; RE0053027.
RX PUBMED: 17636028.
RA Tian Y., Kolb R., Hong J. H., Carroll J., Li D., You J., Bronson R., Yaffe M. B., Zhou J., Benjamin T.
RT TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.
RL Mol. Cell. Biol. 27:6383-6395 (2007).
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