TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T09162 XX ID T09162 XX DT 31.07.2006 (created); res. DT 29.05.2014 (updated); jtr. CO Copyright (C), QIAGEN. XX FA Pax-3 XX SY HuP2 (human); mPax-3; mPax3; PAX3. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G006531 Pax3. XX CL C0018; paired-homeo; XX SZ 479 AA; 53.0 kDa (cDNA) (calc.), 56 kDa (SDS) [1] XX SQ MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIV SQ EMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEE SQ YKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEES SQ EKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFER SQ THYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMP SQ TLPTYQLSEHSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNADSSSAYCLPSTR SQ HGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLE SQ PTTTVSASCSQRLEHMKNVDSLPTSQPYCPPTYSTAGYSMDPVTGYQYGQYGQSKPWTF XX SC Swiss-Prot#P24610 XX FT 1 90 transcription inhibiting region [6]. FT 34 159 PF00292; 'Paired box' domain. FT 34 159 SM00351; pax3. FT 34 161 PS51057; PAIRED_2. FT 217 277 PS50071; HOMEOBOX_2. FT 219 275 PS50552; PAX. FT 219 281 SM00389; HOX_1. FT 220 276 PF00046; Homeobox domain. FT 402 479 transcription activating region [6]. XX IN T11250 Brachyury; mouse, Mus musculus. IN T28743 Hp1-gamma; human, Homo sapiens. IN T28779 Hp1-gamma; human, Homo sapiens. IN T17238 Msx-1; human, Homo sapiens. IN T17026 RNF96; human, Homo sapiens. IN T08441 Sox-10; rat, Rattus norvegicus. IN T25795 TAZ-isoform1; mouse, Mus musculus. IN T22859 TAZ; mouse, Mus musculus. IN T16161 Tbx15; mouse, Mus musculus. IN T11332 Tbx18; mouse, Mus musculus. IN T11216 Tbx22-isoform2; human, Homo sapiens. XX MX M00360 V$PAX3_01. MX M00327 V$PAX3_B. MX M00808 V$PAX_Q6. XX BS R08534. BS R08535. BS R08536. BS R08537. BS R08538. BS R08539. BS R08540. BS R08541. BS R08542. BS R08543. BS R08544. BS R08545. BS R08546. BS R08547. BS R08548. BS R08549. BS R08550. BS R08551. BS R08552. BS R08553. BS R08554. BS R08555. BS R08556. BS R08557. BS R08558. BS R08559. BS R09451. BS R09450. BS R02801. BS R08678. BS R31214. BS R33349. BS R33350. BS R29911. BS R62106. BS R62109. BS R33352. BS R34262. BS R20677. BS R20678. BS R20679. BS R20681. BS R20682. BS R20684. BS R20685. XX DR TRANSPATH: MO000083953. DR EMBL: S66429; DR EMBL: S66433; DR EMBL: X59358; DR UniProtKB: P24610; XX RN [1]; RE0002795. RX PUBMED: 2022185. RA Goulding M. D., Chalepakis G., Deutsch U., Erselius J. R., Gruss P. RT Pax-3, a novel murine DNA binding protein expressed during early neurogenesis RL EMBO J. 10:1135-1147 (1991). RN [2]; RE0004215. RX PUBMED: 8421686. RA Epstein D. J., Vogan K. J., Trasler D. G., Gros P. RT A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant RL Proc. Natl. Acad. Sci. USA 90:532-536 (1993). RN [3]; RE0004244. RX PUBMED: 8099544. RA Maulbecker C. C., Gruss P. RT The oncogenic potential of Pax genes RL EMBO J. 12:2361-2367 (1993). RN [4]; RE0004245. RX PUBMED: 7909605. RA Chalepakis G., Goulding M., Read A., Strachan T., Gruss P. RT Molecular basis of splotch and Waardenburg Pax-3 mutations RL Proc. Natl. Acad. Sci. USA 91:3685-3689 (1994). RN [5]; RE0004246. RX PUBMED: 8065927. RA Chalepakis G., Wijnholds J., Gruss P. RT Pax-3 - DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains RL Nucleic Acids Res. 22:3131-3137 (1994). RN [6]; RE0004247. RX PUBMED: 7809114. RA Chalepakis G., Jones F. S., Edelman G. M., Gruss P. RT Pax-3 contains domains for transcription activation and transcription inhibition RL Proc. Natl. Acad. Sci. USA 91:12745-12749 (1994). RN [7]; RE0004248. RX PUBMED: 7744814. RA Epstein J. A., Lam P., Jepeal L., Maas R. L., Shapiro D. N. RT Pax3 inhibits myogenic differentiation of cultured myoblast cells RL J. Biol. Chem. 270:11719-11722 (1995). RN [8]; RE0004249. RX PUBMED: 8162858. RA Bober E., Franz T., Arnold H. H., Gruss P., Tremblay P. RT Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells RL Development 120:603-612 (1994). RN [9]; RE0004250. RX PUBMED: 7600971. RA Goulding M., Lumsden A., Paquette A. J. RT Regulation of Pax-3 expression in the dermomyotome and its role in muscle development RL Development 120:957-971 (1994). RN [10]; RE0004253. RX PUBMED: 1682057. RA Epstein D. J., Vekemans M., Gros P. RT Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3 RL Cell 67:767-774 (1991). RN [11]; RE0004254. RX PUBMED: 8406487. RA Vogan K. J., Epstein D. J., Trasler D. G., Gros P. RT The splotch-delayed (Spd) mouse mutant carries a point mutation within the paired box of the Pax-3 gene RL Genomics 17:364-369 (1993). RN [12]; RE0006702. RX PUBMED: 8929535. RA Ericson J., Morton S., Kawakami A., Roelink H., Jessell T. M. RT Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity RL Cell 87:661-673 (1996). RN [13]; RE0007031. RX PUBMED: 8633043. RA Epstein J. A., Shapiro D. N., Cheng J., Lam P. Y. P., Maas R. L. RT Pax3 modulates expression of the c-Met receptor during limb muscle development. RL Proc. Natl. Acad. Sci. USA 93:4213-4218 (1996). RN [14]; RE0010761. RX PUBMED: 7731966. RA Underhill D. A., Vogan K. J., Gros P. RT Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity RL Proc. Natl. Acad. Sci. USA 92:3692-3696 (1995). RN [15]; RE0014013. RX PUBMED: 7557441. RA Chalepakis G., Gruss P. RT Identification of DNA recognition sequences for the Pax3 paired domain RL Gene 162:267-270 (1995). RN [16]; RE0014025. RX PUBMED: 9475182. RA Reeves F. C., Fredericks W. J., Rauscher F. J. 3rd, Lillycrop K. A. RT The DNA binding activity of the paired box transcription factor Pax-3 is rapidly downregulated during neuronal cell differentiation RL FEBS Lett. 422:118-122 (1998). RN [17]; RE0014075. RX PUBMED: 9731536. RA Magnaghi P., Roberts C., Lorain S., Lipinski M., Scambler P. J. RT HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3 RL Nat. Genet. 20:74-77 (1998). RN [18]; RE0014085. RX PUBMED: 9464541. RA Wiggan O., Taniguchi-Sidle A., Hamel P. A. RT Interaction of the pRB-family proteins with factors containing paired-like homeodomains RL Oncogene 16:227-236 (1998). RN [19]; RE0014110. RX PUBMED: 8631247. RA Daston G., Lamar E., Olivier M., Goulding M. RT Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse RL Development 122:1017-1027 (1996). RN [20]; RE0014112. RX PUBMED: 8681797. RA Yang X. M., Vogan K., Gros P., Park M. RT Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice RL Development 122:2163-2171 (1996). RN [21]; RE0015185. RX PUBMED: 7545667. RA Kallunki P., Jenkinson S., Edelman G. M., Jones F. S. RT Silencer elements modulate the expression of the gene for the neuron-glia cell adhesion molecule, Ng-CAM RL J. Biol. Chem. 270:21291-21298 (1995). RN [22]; RE0024470. RX PUBMED: 12668617. RA Lang D., Epstein J. A. RT Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer. RL Hum. Mol. Genet. 12:937-945 (2003). RN [23]; RE0026514. RX PUBMED: 10871843. RA Margue C. M., Bernasconi M., Barr F. G., Schafer B. W. RT Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR. RL Oncogene 19:2921-9 (2000). RN [24]; RE0047961. RX PUBMED: 15143176. RA Ploski J. E., Shamsher M. K., Radu A. RT Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13. RL Mol. Cell. Biol. 24:4824-4834 (2004). RN [25]; RE0047965. RX PUBMED: 10748034. RA Kovac C. R., Emelyanov A., Singh M., Ashouian N., Birshtein B. K. RT BSAP (Pax5)-importin alpha 1 (Rch1) interaction identifies a nuclear localization sequence. RL J. Biol. Chem. 275:16752-16757 (2000). RN [26]; RE0053016. RX PUBMED: 16300735. RA Murakami M., Tominaga J., Makita R., Uchijima Y., Kurihara Y., Nakagawa O., Asano T., Kurihara H. RT Transcriptional activity of Pax3 is co-activated by TAZ. RL Biochem. Biophys. Res. Commun. 339:533-539 (2006). RN [27]; RE0064970. RX PUBMED: 10529415. RA Bendall A. J., Ding J., Hu G., Shen M. M., Abate-Shen C. RT Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors. RL Development 126:4965-4976 (1999). RN [28]; RE0065185. RX PUBMED: 19458195. RA Kumar D., Shadrach J. L., Wagers A. J., Lassar A. B. RT Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells. RL Mol. Biol. Cell 20:3170-3177 (2009). RN [29]; RE0066940. RX PUBMED: 17662948. RA Boutet S. C., Disatnik M. H., Chan L. S., Iori K., Rando T. A. RT Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors. RL Cell 130:349-362 (2007). RN [30]; RE0066950. RX PUBMED: 16945326. RA Hsieh M. J., Yao Y. L., Lai I. L., Yang W. M. RT Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1. RL Biochem. Biophys. Res. Commun. 349:573-581 (2006). RN [31]; RE0066970. RX PUBMED: 18644785. RA Farin H. F., Mansouri A., Petry M., Kispert A. RT T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm. RL J. Biol. Chem. 283:25372-25380 (2008). XX //