TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T05347 AS T05338. XX ID T05347 XX DT 08.11.2002 (created); oke. DT 25.06.2015 (updated); msr. CO Copyright (C), QIAGEN. XX FA PPARgamma XX SY NR1C3; peroxisome proliferator-activated receptor gamma; PPARG; PPARgamma. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G004880 Pparg. XX CL C0002; CC (rec); XX SF Two variants are known: PPARgamma1 T02529 and PPARgamma2 T05332 which result from different promoters and alternative splicing [1]; SF forms heterodimers with RXR-alpha; XX CP Mouse embryonic fibroblast (MEF) cells [21]. XX FF PPARgamma drives mesenchymal stem cells to differentiate into adipocytes [26]; FF activator as a heterodimer with RXR-alpha; FF ligands: fatty acids, prostaglandins [2]; FF mRNA expression is induced by PPAR-beta in adipocytes [2]; FF one of the key regulators of adipogenesis; XX IN T05777 ASC-2-isoform1; mouse, Mus musculus. IN T15118 CBP; Mammalia. IN T25698 DRIP205-isoform4; mouse, Mus musculus. IN T23418 HDAC1; mouse, Mus musculus. IN T04688 NCOR1; mouse, Mus musculus. IN T17544 NFATc1b; mouse, Mus musculus. IN T05296 PGC-1; mouse, Mus musculus. IN T19194 PRIC285; human, Homo sapiens. IN T01331 RXR-alpha; mouse, Mus musculus. IN T04689 SMRT; human, Homo sapiens. IN T04690 SMRT; mouse, Mus musculus. IN T21552 SRC-1; Mammalia. IN T22859 TAZ; mouse, Mus musculus. XX MX M00763 V$PPARDR1_Q2. MX M02262 V$PPARGRXRA_01. MX M00512 V$PPARG_01. MX M00515 V$PPARG_02. MX M00528 V$PPARG_03. MX M01270 V$PPARG_Q6. XX BS R07669. BS R19281. BS R30923. BS R27359. BS R63128. BS R65977. BS R27269. BS R33843. BS R33844. BS R27479. BS R20247. BS R28461. BS R56946. BS R39202. BS R73620. BS R73623. BS R73624. BS R63312. BS R19242. BS R72447. BS R72450. BS R27357. BS R73273. BS R73274. BS R19271. BS R73077. BS R67931. BS R27261. BS R19238. BS R63918. BS R63919. BS R31301. BS R41679. BS R03986. BS R22744. BS R68568. BS R68574. BS R68576. BS R20237. BS R42170. XX DR TRANSPATH: MO000033558. DR UniProtKB: P37238; XX RN [1]; RE0011113. RX PUBMED: 7644514. RA Zhu Y., Qi C., Korenberg J. R., Chen X.-N., Noya D., Rao M. S., Reddy J. K. RT Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPARgamma) gene: Alternative promoter use and different splicing yield two mPPARgamma isoforms RL Proc. Natl. Acad. Sci. USA 92:7921-7929 (1995). RN [2]; RE0018259. RX PUBMED: 10419513. RA Bastie C., Holst D., Gaillard D., Jehl-Pietri C., Grimaldi P. A. RT Expression of peroxisome proliferator-activated receptor PPARdelta promotes induction of PPARgamma and adipocyte differentiation in 3T3C2 fibroblasts. RL J. Biol. Chem. 274:21920-21925 (1999). RN [3]; RE0018281. RX PUBMED: 8041794. RA Kliewer S. A., Forman B. M., Blumberg B., Ong E. S., Borgmeyer U., Mangelsdorf D. J., Umesono K., Evans R. M. RT Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. RL Proc. Natl. Acad. Sci. USA 91:7355-7359 (1994). RN [4]; RE0026435. RX PUBMED: 10788465. RA Zhu Y., Kan L., Qi C., Kanwar Y. S., Yeldandi A. V., Rao M. S., Reddy J. K. RT Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. RL J. Biol. Chem. 275:13510-6 (2000). RN [5]; RE0040618. RX PUBMED: 9325263. RA Zhu Y., Qi C., Jain S., Rao M. S., Reddy J. K. RT Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor RL J. Biol. Chem. 272:25500-6 (1997). RN [6]; RE0040896. RX PUBMED: 11226238. RA Wolfrum C., Borrmann C. M., Borchers T., Spener F. RT Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma -mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus RL Proc. Natl. Acad. Sci. USA 98:2323-2328 (2001). RN [7]; RE0046904. RX PUBMED: 11909955. RA Akiyama T. E., Sakai S., Lambert G., Nicol C. J., Matsusue K., Pimprale S., Lee Y. H., Ricote M., Glass C. K., Brewer H. B. Jr, Gonzalez F. J. RT Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux RL Mol. Cell. Biol. 22:2607-19 (2002). RN [8]; RE0047776. RX PUBMED: 16260612. RA Sarruf D. A., Iankova I., Abella A., Assou S., Miard S., Fajas L. RT Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma. RL Mol. Cell. Biol. 25:9985-9995 (2005). RN [9]; RE0047805. RX PUBMED: 15687259. RA Drori S., Girnun G. D., Tou L., Szwaya J. D., Mueller E., Xia K., Shivdasani R. A., Spiegelman B. M. RT Hic-5 regulates an epithelial program mediated by PPARgamma. RL Genes Dev. 19:362-375 (2005). RN [10]; RE0047835. RX PUBMED: 14573767. RA Chung S. W., Kang B. Y., Kim T. S. RT Inhibition of interleukin-4 production in CD4+ T cells by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: involvement of physical association between PPAR-gamma and the nuclear factor of activated T cells transcription factor. RL Mol. Pharmacol. 64:1169-1179 (2003). RN [11]; RE0047960. RX PUBMED: 8910358. RA Chu R., Lin Y., Rao M. S., Reddy J. K. RT Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha. RL J. Biol. Chem. 271:27670-27676 (1996). RN [12]; RE0048262. RX PUBMED: 16210377. RA Singh R., Artaza J. N., Taylor W. E., Braga M., Yuan X., Gonzalez-Cadavid N. F., Bhasin S. RT Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. RL Endocrinology 147:141-154 (2006). RN [13]; RE0048421. RX PUBMED: 16219912. RA Johnson D. R., Li C. W., Chen L. Y., Ghosh J. C., Chen J. D. RT Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). RL Mol. Pharmacol. 69:99-108 (2006). RN [14]; RE0048488. RX PUBMED: 15691842. RA Yu C., Markan K., Temple K. A., Deplewski D., Brady M. J., Cohen R. N. RT The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. RL J. Biol. Chem. 280:13600-13605 (2005). RN [15]; RE0049238. RX PUBMED: 16534556. RA Shimizu M., Yamashita D., Yamaguchi T., Hirose F., Osumi T. RT Aspects of the regulatory mechanisms of PPAR functions: analysis of a bidirectional response element and regulation by sumoylation. RL Mol. Cell. Biochem. 286:33-42 (2006). RN [16]; RE0050226. RX PUBMED: 16198309. RA Soares A. F., Nosjean O., Cozzone D., D'Orazio D., Becchi M., Guichardant M., Ferry G., Boutin J. A., Lagarde M., Geloen A. RT Covalent binding of 15-deoxy-delta12,14-prostaglandin J2 to PPARgamma. RL Biochem. Biophys. Res. Commun. 337:521-525 (2005). RN [17]; RE0050364. RX PUBMED: 12573447. RA Soderstrom M., Wigren J., Surapureddi S., Glass C. K., Hammarstrom S. RT Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures. RL Biochim. Biophys. Acta 1631:35-41 (2003). RN [18]; RE0050413. RX PUBMED: 12740008. RA Wigren J., Surapureddi S., Olsson A. G., Glass C. K., Hammarstrom S., Soderstrom M. RT Differential recruitment of the coactivator proteins CREB-binding protein and steroid receptor coactivator-1 to peroxisome proliferator-activated receptor gamma/9-cis-retinoic acid receptor heterodimers by ligands present in oxidized low-density lipoprotein. RL J. Endocrinol. 177:207-214 (2003). RN [19]; RE0050569. RX PUBMED: 17595322. RA Li D., Kang Q., Wang D. M. RT CCPG, a Novel Constitutive Coactivator of PPAR{gamma} that Promotes Adipogenesis. RL Mol. Endocrinol. 21:2320-2333 (2007). RN [20]; RE0050933. RX PUBMED: 16127449. RA Pascual G., Fong A. L., Ogawa S., Gamliel A., Li A. C., Perissi V., Rose D. W., Willson T. M., Rosenfeld M. G., Glass C. K. RT A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. RL Nature 437:759-763 (2005). RN [21]; RE0051377. RX PUBMED: 16407166. RA Sastre M., Dewachter I., Rossner S., Bogdanovic N., Rosen E., Borghgraef P., Evert B. O., Dumitrescu-Ozimek L., Thal D. R., Landreth G., Walter J., Klockgether T., van Leuven F., Heneka M. T. RT Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. RL Proc. Natl. Acad. Sci. USA 103:443-448 (2006). RN [22]; RE0051542. RX PUBMED: 12935909. RA Takahashi N., Kawada T., Goto T., Kim C. S., Taimatsu A., Egawa K., Yamamoto T., Jisaka M., Nishimura K., Yokota K., Yu R., Fushiki T. RT Abietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism. RL FEBS Lett. 550:190-194 (2003). RN [23]; RE0064905. RX PUBMED: 16461908. RA Majdalawieh A., Zhang L., Fuki I. V., Rader D. J., Ro H. S. RT Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation. RL Proc. Natl. Acad. Sci. USA 103:2346-2351 (2006). RN [24]; RE0065384. RX PUBMED: 15930175. RA Hogan J. C., Stephens J. M. RT Effects of leukemia inhibitory factor on 3T3-L1 adipocytes. RL J. Endocrinol. 185:485-496 (2005). RN [25]; RE0067469. RX PUBMED: 18562323. RA White U. A., Stewart W. C., Mynatt R. L., Stephens J. M. RT Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes. RL J. Biol. Chem. 283:22505-22512 (2008). RN [26]; RE0035398. RX PUBMED: 16099986. RA Hong J. H., Hwang E. S., McManus M. T., Amsterdam A., Tian Y., Kalmukova R., Mueller E., Benjamin T., Spiegelman B. M., Sharp P. A., Hopkins N., Yaffe M. B. RT TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. RL Science 309:1074-1078 (2005). XX //