AC T04688
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ID T04688
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DT 03.09.2001 (created); mas.
DT 15.05.2013 (updated); spk.
CO Copyright (C), QIAGEN.
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FA NCOR1
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SY N-COR; N-COR1; nuclear receptor co-repressor; retinoid X receptor interacting protein 13; RXRIP13.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002796 Ncor1.
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CL C0022; trp; 3.5.1.2.1.
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SF contains separate domains for interaction with nuclear receptors and repression function, respectively, compare to [3];
SF existence of a splice variant that lacks amino acid 2333 to 2371 [2];
SF binds to nuclear receptors preferentially in ligand-unbound state [2];
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EX brain,,,adult; detectable; Northern blot; mRNA (poly-A); [2].
EX cortical plate,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [4].
EX external granular layer of isocortex,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [4].
EX external pyramidal layer of isocortex,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [4].
EX heart,,,adult; detectable; Northern blot; mRNA (poly-A); [2].
EX kidney (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [2].
EX liver,,,adult; detectable; Northern blot; mRNA (poly-A); [2].
EX lung,,,adult; detectable; Northern blot; mRNA (poly-A); [2].
EX marginal layer of future cebral cortex,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [4].
EX muscles,,,adult; detectable; Northern blot; mRNA (poly-A); [2].
EX spleen,,,adult; detectable; Northern blot; mRNA (poly-A); [2].
EX testis (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [2].
EX thalamus,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [4].
EX thymic stroma,,,Theiler Stage 22; low; Western blot; protein; [4].
EX thymic stroma,,,Theiler Stage 23; low; Western blot; protein; [4].
EX thymus,,,Theiler Stage 22; detectable; Western blot; protein; [4].
EX thymus,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [4].
EX thymus,,,Theiler Stage 23; detectable; Western blot; protein; [4].
EX thymus,thymocyte,,Theiler Stage 22; detectable; Western blot; protein; [4].
EX thymus,thymocyte,,Theiler Stage 23; detectable; Western blot; protein; [4].
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FF involved in mediation of transcriptional repressive effect of (unliganded) nuclear receptors (direct binding to nuclear receptors) [2] [1];
FF recruitment of histone deacetylase complexes which is important for transcriptional repression [1];
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IN T16043 BCL-6; Mammalia.
IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T08969 nanog; mouse, Mus musculus.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T02336 PLZF; human, Homo sapiens.
IN T00694 PPARalpha; mouse, Mus musculus.
IN T05347 PPARgamma; mouse, Mus musculus.
IN T00720 RAR-gamma; human, Homo sapiens.
IN T01331 RXR-alpha; mouse, Mus musculus.
IN T08433 RXR-alpha; human, Homo sapiens.
IN T09964 RXR-alpha; Mammalia.
IN T04810 T3R-alpha:RXR-alpha; human, Homo sapiens.
IN T00838 T3R-alpha; human, Homo sapiens.
IN T00851 T3R-beta1; human, Homo sapiens.
IN T15588 T3R-beta1; Mammalia.
IN T16580 T3R-beta; Mammalia.
IN T08482 VDR-isoform1; human, Homo sapiens.
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DR TRANSPATH: MO000028509.
DR UniProtKB: Q60974;
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RN [1]; RE0006125.
RX PUBMED: 9139820.
RA Heinzel T., Lavinsky R. M., Mullen T. M., Soederstroem M., Laherty C. D., Torchia J., Yang W. M., Brard G., Ngo S. D., Davie J. R., Seto E., Eisenman R. N., Rose D. W., Glass C. K., Rosenfeld M. G.
RT A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
RL Nature 387:43-48 (1997).
RN [2]; RE0010819.
RX PUBMED: 7566114.
RA Hoerlein A. J., Naeaer A. M., Heinzel T., Torchia J., Gloss B., Kurokawa R., Ryan A., Kamei Y., Soederstroem M., Glass C. K., Rosenfeld M. G.
RT Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
RL Nature 377:397-404 (1995).
RN [3]; RE0016802.
RX PUBMED: 10617570.
RA Nagy L., Kao H. Y., Love J. D., Li C., Banayo E., Gooch J. T., Krishna V., Chatterjee K., Evans R. M., Schwabe J. W.
RT Mechanism of corepressor binding and release from nuclear hormone receptors
RL Genes Dev. 13:3209-3216 (1999).
RN [4]; RE0016806.
RX PUBMED: 11030619.
RA Jepsen K., Hermanson O., Onami T. M., Gleiberman A. S., Lunyak V., McEvilly R. J., Kurokawa R., Kumar V., Liu F., Seto E., Hedrick S. M., Mandel G., Glass C. K., Rose D. W., Rosenfeld M. G.
RT Combinatorial roles of the nuclear receptor corepressor in transcription and development
RL Cell 102:753-763 (2000).
RN [5]; RE0016813.
RX PUBMED: 10336495.
RA Dowell P., Ishmael J. E., Avram D., Peterson V. J., Nevrivy D. J., Leid M.
RT Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein
RL J. Biol. Chem. 274:15901-15907 (1999).
RN [6]; RE0037630.
RX PUBMED: 12890497.
RA Tai H. H., Geisterfer M., Bell J. C., Moniwa M., Davie J. R., Boucher L., McBurney M. W.
RT CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins
RL Biochem. Biophys. Res. Commun. 308:170-6 (2003).
RN [7]; RE0038030.
RX PUBMED: 11509652.
RA Guenther M. G., Barak O., Lazar M. A.
RT The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
RL Mol. Cell. Biol. 21:6091-101 (2001).
RN [8]; RE0047375.
RX PUBMED: 11891224.
RA Gonzalez M. M., Carlberg C.
RT Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors.
RL J. Biol. Chem. 277:18501-18509 (2002).
RN [9]; RE0047433.
RX PUBMED: 9878542.
RA Tagami T., Lutz W. H., Kumar R., Jameson J. L.
RT The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators.
RL Biochem. Biophys. Res. Commun. 253:358-363 (1998).
RN [10]; RE0047648.
RX PUBMED: 15336696.
RA Loinder K., Soderstrom M.
RT Functional analyses of an LXXLL motif in nuclear receptor corepressor (N-CoR).
RL J. Steroid Biochem. Mol. Biol. 91:191-196 (2004).
RN [11]; RE0048488.
RX PUBMED: 15691842.
RA Yu C., Markan K., Temple K. A., Deplewski D., Brady M. J., Cohen R. N.
RT The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis.
RL J. Biol. Chem. 280:13600-13605 (2005).
RN [12]; RE0048530.
RX PUBMED: 11865059.
RA Melnick A., Carlile G., Ahmad K. F., Kiang C. L., Corcoran C., Bardwell V., Prive G. G., Licht J. D.
RT Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.
RL Mol. Cell. Biol. 22:1804-1818 (2002).
RN [13]; RE0048879.
RX PUBMED: 11818500.
RA Marimuthu A., Feng W., Tagami T., Nguyen H., Jameson J. L., Fletterick R. J., Baxter J. D., West B. L.
RT TR surfaces and conformations required to bind nuclear receptor corepressor.
RL Mol. Endocrinol. 16:271-286 (2002).
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