AC T01331
XX
ID T01331
XX
DT 25.10.1994 (created); ewi.
DT 23.05.2016 (updated); jtr.
CO Copyright (C), QIAGEN.
XX
FA RXR-alpha
XX
SY NR2B1; retinoid X receptor alpha; RXR-alpha.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006695 Rxra.
XX
CL C0002; CC (rec); 2.1.3.1.1.
XX
SF binds to DNA as a homodimer or as a heterodimer with a number of different nuclear receptors: RAR-alpha, -beta, -gamma, TR-alpha, ARP-1, PPAR-alpha, PPAR-gamma, VDR, CAR, LXR-alpah, LXR-beta, FXR, FXRbeta;
SF for heterodimers, see ;
SF formation of homodimers on DNA is inhibited in the presence of a heteromeric partner, for example LXR-beta [7];
XX
CP (embryo:) expressed on E10.5, E11.5, E12.5, E13.5, E14.5, E15.5, E16.5, E17.5, E18.5 [4]; E 16.5 (in situ): strong signals in epithelia of digestive system, skin, liver and weaker signals in central nervous system, skeleton [4]; (adult:) liver; kidney, lung, muscle, spleen, skin; (weak:) adrenal, brain, heart, intestine; P3 (in situ):liver, villi of small intestine, epithelia of colon [4] [4].
CN testis.
XX
FF natural occurring high affinity ligand (retinoid X) is 9-cis retinoic acid which induces transactivation activity [4];
FF responds to a variety of endogenous retinoids, but again 9-cis retinoic acid is most potent ligand with high transactivation activity (up to 40-fold more active than all-trans retinoic acid) [4];
FF all-trans retinoic acid which is low affinity ligand could serve as a metabolic precursor for a high affinity ligands like 9-cis retinoic acid [4];
FF 9-cis retinoic acid retinoic acid-dependent homo- and heterodimerization;
FF AF-2 is ligand-inducible and promoter context-dependent;
FF modulating function is also promoter context-dependent, but ligand-independent;
FF classical DNA binding element for homodimers is DR1 [7];
XX
IN T08261 CAR; mouse, Mus musculus.
IN T00149 COUP-TF1; human, Homo sapiens.
IN T00217 EcR; fruit fly, Drosophila melanogaster.
IN T05309 FXR-isoform3; human, Homo sapiens.
IN T02753 FXR; mouse, Mus musculus.
IN T04430 LXR-alpha; mouse, Mus musculus.
IN T04688 NCOR1; mouse, Mus musculus.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T01327 NR1B1; mouse, Mus musculus.
IN T01356 NR1B1; clawed frog, Xenopus laevis.
IN T00721 NR1B2; human, Homo sapiens.
IN T01328 NR1B2; mouse, Mus musculus.
IN T04938 Nrf2; mouse, Mus musculus.
IN T00694 PPARalpha; mouse, Mus musculus.
IN T03731 PPARgamma2; human, Homo sapiens.
IN T05332 PPARgamma2; mouse, Mus musculus.
IN T05347 PPARgamma; mouse, Mus musculus.
IN T01330 RAR-gamma1; human, Homo sapiens.
IN T00720 RAR-gamma; human, Homo sapiens.
IN T01329 RAR-gamma; mouse, Mus musculus.
IN T01152 T3R-alpha1; human, Homo sapiens.
IN T01173 T3R-alpha2; mouse, Mus musculus.
IN T00841 T3R-alpha; rat, Rattus norvegicus.
IN T01351 T3R-alpha; chick, Gallus gallus.
IN T00851 T3R-beta1; human, Homo sapiens.
IN T02482 TIF2; mouse, Mus musculus.
IN T00885 VDR; human, Homo sapiens.
XX
MX M00966 V$DR3_Q4.
MX M00965 V$DR4_Q2.
MX M07280 V$NR1NR2_Q3.
MX M00518 V$PPARA_02.
MX M02262 V$PPARGRXRA_01.
MX M02791 V$RXRA_03.
MX M02895 V$RXRA_04.
MX M07125 V$RXRA_11.
MX M09003 V$RXRA_13.
MX M00963 V$T3R_Q6.
XX
BS R23650.
BS R04448.
BS R01465.
BS R38690.
BS R01321.
BS R59825.
BS R10074.
BS R04451.
BS R04769.
BS R04770.
BS R27207.
BS R20554.
BS R38694.
BS R35987.
BS R39199.
XX
DR TRANSPATH: MO000025590.
DR UniProtKB: P28700;
XX
RN [1]; RE0000264.
RX PUBMED: 1327537.
RA Durand B., Saunders M., Leroy P., Leid M., Chambon P.
RT All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs
RL Cell 71:73-85 (1992).
RN [2]; RE0000265.
RX PUBMED: 1310259.
RA Leid M., Kastner P., Lyons R., Nakshatri H., Saunders M., Zacharewski T., Chen J.-Y., Staub A., Garnier J.-M., Mader S., Chambon P.
RT Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently
RL Cell 68:377-395 (1992).
RN [3]; RE0000270.
RX PUBMED: 1326406.
RA Nagpal S., Saunders M., Kastner P., Durand B., Nakshatri H., Chambon P.
RT Promoter context-and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors
RL Cell 70:1007-1019 (1992).
RN [4]; RE0000789.
RX PUBMED: 1312497.
RA Mangelsdorf D. J., Borgmeyer U., Heyman R. A., Zhou J. Y., Ong E. S., Oro A. E., Kakizuka A., Evans R. M.
RT Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
RL Genes Dev. 6:329-344 (1992).
RN [5]; RE0000793.
RX PUBMED: 8392478.
RA Perlmann T., Rangarajan P. N., Umesono K., Evans R. M.
RT Determinants for selective RAR and TR recognition of direct repeat HREs
RL Genes Dev. 7:1411-1422 (1993).
RN [6]; RE0001916.
RX PUBMED: 1323763.
RA Zhang X.-K., Lehmann J., Hoffmann B., Dawson M. I., Cameron J., Graupner G., Hermann T., Tran P., Pfahl M.
RT Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid
RL Nature 358:587-591 (1992).
RN [7]; RE0017079.
RX PUBMED: 10187832.
RA Feltkamp D., Wiebel F. F., Alberti S., Gustafsson J. A.
RT Identification of a novel DNA binding site for nuclear orphan receptor OR1
RL J. Biol. Chem. 274:10421-10429 (1999).
RN [8]; RE0029349.
RX PUBMED: 10383391.
RA Adam-Stitah S., Penna L., Chambon P., Rochette-Egly C.
RT Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases.
RL J. Biol. Chem. 274:18932-41 (1999).
RN [9]; RE0048304.
RX PUBMED: 15340055.
RA Kodama S., Koike C., Negishi M., Yamamoto Y.
RT Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.
RL Mol. Cell. Biol. 24:7931-7940 (2004).
XX
//