AC T01152
XX
ID T01152
XX
DT 26.04.1994 (created); ewi.
DT 09.01.2015 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA T3R-alpha1
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SY c-erbA-1; EAR-7; EAR7; NR1A1; Nuclear receptor subfamily 1 group A member 1; T3R-alpha1; thyroid hormone receptor alpha; thyroid hormone receptor alpha1; TR; TR-alpha.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004672 THRA; HGNC: THRA.
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CL C0002; CC (rec); 2.1.2.2.1.1.
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SZ 410 AA; 46.8 kDa (cDNA) (calc.).
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SQ MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
SQ TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
SQ AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
SQ QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
SQ ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
SQ ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
SQ PHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV
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SC Swiss-Prot#P10827-2
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FT 50 123 
SM00399; c4gold.
FT 50 127 
PS51030; NUCLEAR_REC_DBD_2.
FT 51 128 
PF00105; Zinc finger, C4 type (two domains).
FT 83 329 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 220 378 
SM00430; holi.
FT 223 404 
PF00104; Ligand-binding domain of nuclear hormon.
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SF zinc-dependent folding;
SF splice variant from THRA (c-arbA-1) gene [4];
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FF DNA-binding is zinc-dependent;
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IN T08796 ASC-2; human, Homo sapiens.
IN T33929 DRIP205-isoform1; human, Homo sapiens.
IN T33762 DRIP205; human, Homo sapiens.
IN T10361 Oct-2; Mammalia.
IN T08628 POU2F1; Mammalia.
IN T01331 RXR-alpha; mouse, Mus musculus.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T01359 RXR-alpha; clawed frog, Xenopus laevis.
IN T08433 RXR-alpha; human, Homo sapiens.
IN T04689 SMRT; human, Homo sapiens.
IN T00818 TFIIB; human, Homo sapiens.
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MX M01724 V$T3RALPHA_Q6.
MX M00963 V$T3R_Q6.
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BS R01465.
BS R03939.
BS R03940.
BS R04765.
BS R04766.
BS R04767.
BS R03523.
BS R01906.
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DR TRANSPATH: MO000025446.
DR EMBL: M24748;
DR UniProtKB: P10827-2;
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RN [1]; RE0000565.
RX PUBMED: 1954886.
RA Miyamoto T., Sakurai A., DeGroot L. J.
RT Effects of zinc and other divalent metals on deoxyribonucleic acid binding and hormone-binding activity of human alpha1 thyroid hormone receptor expressed in Escherichia coli
RL Endocrinology 129:3027-3033 (1991).
RN [2]; RE0001853.
RX PUBMED: 2569164.
RA Sap J., Munoz A., Schmitt J., Stunnenberg H., Vennstroem B.
RT Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product
RL Nature 340:242 (1989).
RN [3]; RE0001917.
RX PUBMED: 1310350.
RA Zhang X. K., Hoffmann B., Tran P. B.-V., Graupner G., Pfahl M.
RT Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors
RL Nature 355:441-446 (1992).
RN [4]; RE0002102.
RX PUBMED: 1850510.
RA Laudet V., Begue A., Henry-Duthoit C., Joubel A., Martin P., Stehelin D., Saule S.
RT Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene
RL Nucleic Acids Res. 19:1105-1112 (1991).
RN [5]; RE0013624.
RX PUBMED: 2464749.
RA Nakai A., Sakurai A., Bell G. I., DeGroot L. J.
RT Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues
RL Mol. Endocrinol. 2:1087-1092 (1988).
RN [6]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [7]; RE0022655.
RX PUBMED: 10982791.
RA Davis P. J., Shih A., Lin H.-Y., Martino L. J., Davis F. B.
RT Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR.
RL J. Biol. Chem. 275:38032-38039 (2000).
RN [8]; RE0025766.
RX PUBMED: 12048199.
RA Lin H. M., Zhao L., Cheng S. Y.
RT Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors.
RL J. Biol. Chem. 277:28733-41 (2002).
RN [9]; RE0025974.
RX PUBMED: 9653119.
RA Yuan C. X., Ito M., Fondell J. D., Fu Z. Y., Roeder R. G.
RT The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
RL Proc. Natl. Acad. Sci. USA 95:7939-44 (1998).
RN [10]; RE0047529.
RX PUBMED: 11641275.
RA Potter G. B., Beaudoin GM 3. r. d., DeRenzo C. L., Zarach J. M., Chen S. H., Thompson C. C.
RT The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.
RL Genes Dev. 15:2687-2701 (2001).
RN [11]; RE0047948.
RX PUBMED: 10383413.
RA Kakizawa T., Miyamoto T., Ichikawa K., Kaneko A., Suzuki S., Hara M., Nagasawa T., Takeda T., Mori J., Kumagai M., Hashizume K.
RT Functional interaction between Oct-1 and retinoid X receptor.
RL J. Biol. Chem. 274:19103-19108 (1999).
RN [12]; RE0050597.
RX PUBMED: 10681503.
RA Caira F., Antonson P., Pelto-Huikko M., Treuter E., Gustafsson J. A.
RT Cloning and characterization of RAP250, a novel nuclear receptor coactivator.
RL J. Biol. Chem. 275:5308-5317 (2000).
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