AC T08796
XX
ID T08796
XX
DT 03.04.2006 (created); man.
DT 22.01.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA ASC-2
XX
SY Activating signal cointegrator 2; AIB3; Amplified in breast cancer protein 3; Cancer-amplified transcriptional coactivator ASC-2; NRC; Nuclear receptor coactivator 6; Peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; RAP250; Thyroid hormone receptor-binding protein; TRBP.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G009073 NCOA6; HGNC: NCOA6.
XX
SZ 2063 AA; 219.1 kDa (cDNA) (calc.).
XX
SQ MVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKD
SQ FKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLR
SQ DLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGIIRMNNPA
SQ TVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPH
SQ HPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQ
SQ GIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLPGPMQQQLQAR
SQ PSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQ
SQ PHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMV
SQ QQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTATT
SQ PGNSGAPQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSG
SQ VPQVNLSNMQGQPQQGPPSQLMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQ
SQ MMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQ
SQ MQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQV
SQ MGIQGQVLRPPGPSPHMAQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNS
SQ ASGNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHF
SQ GVNNKQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGISLDNSG
SQ PKLPEFSNRPPGYPSQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQ
SQ PQSQQQQQQQQQMMMMLMMQQDPKSVRLPVSQNVHPPRGPLNPDSQRMPMQQSGSVPVMV
SQ SLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEASGSEA
SQ PSVPGGPNNMPSHVVLPQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNV
SQ AAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPL
SQ PPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGA
SQ TKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSPTP
SQ LANPPVPGSFPNNSGLNPQNSTVSVAAVGGVVEDNKESLNVPQDSDCQNSQSRKEQVNIE
SQ LKAVPAQEVKMVVPEDQSKKDGQPSDPNKLPSVEENKNLVSPAMREAPTSLSQLLDNSGA
SQ PNVTIKPPGLTDLEVTPPVVSGEDLKKASVIPTLQDLSSSKEPSNSLNLPHSNELCSSLV
SQ HPELSEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSANTSAALPTHL
SQ QSALMSTVVTMPNAGSKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPA
SQ APLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVPPNALSSSPAPNIQTGRPLVLSSRATP
SQ VQLPSPPCTSSPVVPSHPPVQQVKELNPDEASPQVNTSADQNTLPSSQSTTMVSPLLTNS
SQ PGSSGNRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGQGLDTT
SQ APGLMGTEQLSTELDSKTPTPPAPTLLKMTSSPVGPGTASAGPSLPGGALPTSVRSIVTT
SQ LVPSELISAVPTTKSNHGGIASESLAGGLVEEKVGSHPELLPSIAPSQNLVSKETSTTAL
SQ QASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRRNSRTEEPTVASESVENGHRKRSSR
SQ PASASSSTKDITSAVQSKRRKSK
XX
SC translated from EMBL #AF177388
XX
FT 1 67 
acidic domain (D/E-rich) [8].
FT 259 305 
glutamine-rich [8].
FT 887 891 
N-terminal LXXLL-motif [7].
FT 970 1043 
glutamine/proline-rich [8].
FT 1491 1495 
C-terminal LXXLL-motif [7].
FT 1728 2063 
serine/threonine-rich [8].
XX
IN T08796 ASC-2; human, Homo sapiens.
IN T10346 c-Fos; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T18378 CBP; human, Homo sapiens.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T05076 GR; human, Homo sapiens.
IN T01042 HSF1-L; human, Homo sapiens.
IN T05110 Ku70; human, Homo sapiens.
IN T05111 Ku80; human, Homo sapiens.
IN T09029 LXR-beta; human, Homo sapiens.
IN T08888 LXRalpha-isoform1; human, Homo sapiens.
IN T10399 NF-kappaB1-p50; Mammalia.
IN T05299 NR1B1; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T10397 RelA-p65; Mammalia.
IN T08433 RXR-alpha; human, Homo sapiens.
IN T00765 SRF-L; mouse, Mus musculus.
IN T01152 T3R-alpha1; human, Homo sapiens.
IN T08501 T3R-alpha; chick, Gallus gallus.
IN T01350 T3R-beta2; rat, Rattus norvegicus.
IN T08264 T3R-beta; human, Homo sapiens.
IN T08482 VDR-isoform1; human, Homo sapiens.
XX
DR TRANSPATH: MO000079771.
DR EMBL: AF177388;
DR UniProtKB: Q14686;
XX
RN [1]; RE0047527.
RX PUBMED: 10866662.
RA Mahajan M. A., Samuels H. H.
RT A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein.
RL Mol. Cell. Biol. 20:5048-5063 (2000).
RN [2]; RE0047584.
RX PUBMED: 10823961.
RA Ko L., Cardona G. R., Chin W. W.
RT Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.
RL Proc. Natl. Acad. Sci. USA 97:6212-6217 (2000).
RN [3]; RE0047851.
RX PUBMED: 10847592.
RA Lee S. K., Na S. Y., Jung S. Y., Choi J. E., Jhun B. H., Cheong J., Meltzer P. S., Lee Y. C., Lee J. W.
RT Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2.
RL Mol. Endocrinol. 14:915-925 (2000).
RN [4]; RE0048044.
RX PUBMED: 14960326.
RA Hong S., Kim S. H., Heo M. A., Choi Y. H., Park M. J., Yoo M. A., Kim H. D., Kang H. S., Cheong J.
RT Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock.
RL FEBS Lett. 559:165-170 (2004).
RN [5]; RE0048970.
RX PUBMED: 16645037.
RA Tian H., Mahajan M. A., Wong C. T., Habeos I., Samuels H. H.
RT The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain.
RL Mol. Endocrinol. 20:2036-2051 (2006).
RN [6]; RE0050597.
RX PUBMED: 10681503.
RA Caira F., Antonson P., Pelto-Huikko M., Treuter E., Gustafsson J. A.
RT Cloning and characterization of RAP250, a novel nuclear receptor coactivator.
RL J. Biol. Chem. 275:5308-5317 (2000).
RN [7]; RE0023608.
RX PUBMED: 12724417.
RA Kim S. W., Park K., Kwak E., Choi E., Lee S., Ham J., Kang H., Kim J. M., Hwang S. Y., Kong Y. Y., Lee K., Lee J. W.
RT Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.
RL Mol. Cell. Biol. 23:3583-3592 (2003).
RN [8]; RE0023609.
RX PUBMED: 11158331.
RA Lee S. K., Jung S. Y., Kim Y. S., Na S. Y., Lee Y. C., Lee J. W.
RT Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2.
RL Mol. Endocrinol. 15:241-254 (2001).
XX
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